Apurinic/Apyrimidinic Endonuclease 1 and Tyrosyl-DNA Phosphodiesterase 1 Prevent Suicidal Covalent DNA-Protein Crosslink at Apurinic/Apyrimidinic Site

Lebedeva, NA; Rechkunova, NI; Endutkin, AV; Lavrik, OI

Lavrik, OI (corresponding author), Inst Chem Biol & Fundamental Med, Novosibirsk, Russia.; Lavrik, OI (corresponding author), Novosibirsk State Univ, Dept Nat Sci, Novosibirsk, Russia.

FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY, 2021; 8 ():

Abstract

Bifunctional 8-oxoguanine-DNA glycosylase (OGG1), a crucial DNA-repair enzyme, removes from DNA 8-oxo-7,8-dihydroguanine (8-oxoG) with following cleav......

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