CDK5 Inhibitor Downregulates Mcl-1 and Sensitizes Pancreatic Cancer Cell Lines to Navitoclax

Kour, S; Rana, S; Contreras, JI; King, HM; Robb, CM; Sonawane, YA; Bendjennat, M; Crawford, AJ; Barger, CJ; Kizhake, S; Luo, X; Hollingsworth, MA; Natarajan, A

Natarajan, A (reprint author), Univ Nebraska Med Ctr, Fred & Pamela Buffett Canc Ctr, Eppley Inst Res Canc & Allied Dis, Dept Pharmaceut Sci, Omaha, NE 68022 USA.; Natarajan, A (reprint author), Univ Nebraska Med Ctr, Fred & Pamela Buffett Canc Ctr, Epple

MOLECULAR PHARMACOLOGY, 2019; 96 (4): 419

Abstract

Developing small molecules that indirectly regulate Mcl-1 function has attracted a lot of attention in recent years. Here, we report the discovery of ......

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