A Cdk5-derived peptide inhibits Cdk5/p25 activity and improves neurodegenerative phenotypes

Pao, PC; Seo, J; Lee, A; Kritskiy, O; Patnaik, D; Penney, J; Raju, RM; Geigenmuller, U; Silva, MC; Lucente, DE; Gusella, JF; Dickerson, BC; Loon, A; Yu, MX; Bula, M; Yu, M; Haggarty, SJ; Tsai, LH

Tsai, LH (通讯作者)，Picower Inst Learning & Memory, MIT, Cambridge, MA 02139 USA.;Tsai, LH (通讯作者)，MIT, Dept Brain & Cognit Sci, Cambridge, MA 02139 USA.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2023; 120 (16):

Abstract

Aberrant activity of cyclin-dependent kinase (Cdk5) has been implicated in vari-ous neurodegenerative diseases. This deleterious effect is mediated by......

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