E2F1 proteolysis via SCF-cyclin F underlies synthetic lethality between cyclin F loss and Chk1 inhibition

Burdova, K; Yang, HB; Faedda, R; Hume, S; Chauhan, J; Ebner, D; Kessler, BM; Vendrell, I; Drewry, DH; Wells, CI; Hatch, SB; Dianov, GL; Buffa, FM; D'Angiolella, V

D'Angiolella, V (reprint author), Univ Oxford, Med Res Council Inst Radiat Oncol, Dept Oncol, Oxford, England.

EMBO JOURNAL, 2019; 38 (20):

Abstract

Cyclins are central engines of cell cycle progression in conjunction with cyclin-dependent kinases (CDKs). Among the different cyclins controlling cel......

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