APOE deficiency impacts neural differentiation and cholesterol biosynthesis in human iPSC-derived cerebral organoids

Zhao, J; Ikezu, TC; Lu, WY; Macyczko, JR; Li, YH; Lewis-Tuffin, LJ; Martens, YA; Ren, YX; Zhu, YY; Asmann, YW; Ertekin-Taner, N; Kanekiyo, T; Bu, GJ

Zhao, J; Bu, GJ (通讯作者)，Mayo Clin, Dept Neurosci, Jacksonville, FL 32224 USA.;Zhao, J; Bu, GJ (通讯作者)，Mayo Clin, Ctr Regenerat Med, Neuroregenerat Lab, Jacksonville, FL 32224 USA.

STEM CELL RESEARCH & THERAPY, 2023; 14 (1):

Abstract

BackgroundThe apolipoprotein E (APOE) gene is the strongest genetic risk factor for Alzheimer's disease (AD); however, how it modulates brain homeosta......

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