Serine 165 phosphorylation of SHARPIN regulates the activation of NF-kappa B

Thys, A; Trillet, K; Rosinska, S; Gayraud, A; Douanne, T; Danger, Y; Renaud, CCN; Antigny, L; Lavigne, R; Pineau, C; Com, E; Verite, F; Gavard, J; Bidere, N

Bidere, N (corresponding author), Univ Angers, Univ Nantes, CNRS, CRCINA,INSERM, Nantes, France.

ISCIENCE, 2021; 24 (1):

Abstract

The adaptor SHARPIN composes, together with the E3 ligases HOIP and HOIL1, the linear ubiquitin chain assembly complex (LUBAC). This enzymatic complex......

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