2-Oxo-3, 4-dihydropyrimido[4, 5-d]pyrimidinyl derivatives as new irreversible pan fibroblast growth factor receptor (FGFR) inhibitors

Li, XQ; Guise, CP; Taghipouran, R; Yosaatmadja, Y; Ashoorzadeh, A; Paik, WK; Squire, CJ; Jiang, S; Luo, JF; Xu, Y; Tu, ZC; Lu, XY; Ren, XM; Patterson, AV; Smaill, JB; Ding, K

Ding, K (reprint author), Chinese Acad Sci, Guangzhou Inst Biomed & Hlth, Guangdong Prov Key Lab Biocomp, 190 Kaiyuan Ave, Guangzhou 510530, Guangdong, Peoples R China.; Patterson, AV; Smaill, JB (reprint author), Univ Auckland, Sch Med Sci, Auckland Canc

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2017; 135 ( ): 531

Abstract

A series of 2-oxo-3, 4-dihydropyrimido[4,5-d]-pyrimidinyl derivatives were designed and synthesized as new irreversible inhibitors of the FGFR family.......

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