Optimized RNA-targeting CRISPR/Cas13d technology outperforms shRNA in identifying functional circRNAs

Zhang, Y; Nguyen, TM; Zhang, XO; Wang, LM; Phan, T; Clohessy, JG; Pandolfi, PP

Clohessy, JG; Pandolfi, PP (corresponding author), Harvard Med Sch, Beth Israel Deaconess Canc Ctr, Dept Med & Pathol, Beth Israel Deaconess Med Ctr,Canc Res Inst, Boston, MA 02215 USA.

GENOME BIOLOGY, 2021; 22 (1):

Abstract

Short hairpin RNAs (shRNAs) are used to deplete circRNAs by targeting back-splicing junction (BSJ) sites. However, frequent discrepancies exist betwee......

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