A small nuclear acidic protein (MTI-II, Zn2+-binding protein, parathymosin) attenuates TNF-alpha inhibition of BMP-induced osteogenesis by enhancing accessibility of the Smad4-NF-kappa B p65 complex to Smad binding element

Hirata-Tsuchiya, S; Suzuki, S; Okamoto, K; Saito, N; Yuan, H; Yamada, S; Jimi, E; Shiba, H; Kitamura, C

Suzuki, S (corresponding author), Hiroshima Univ, Grad Sch Biomed & Hlth Sci, Dept Biol Endodont, Hiroshima 7348553, Japan.; Suzuki, S (corresponding author), Tohoku Univ, Dept Periodontol & Endodontol, Grad Sch Dent, Aoba Ku, 4-1 Seiryo Machi, Sendai, Miyagi 9808575, Japan.

MOLECULAR AND CELLULAR BIOCHEMISTRY, 2020; 469 (1-2): 133

Abstract

Pro-inflammatory cytokines prevent bone regeneration in vivo and activation of nuclear factor-kappa B (NF-kappa B) signaling has been proposed to lead......

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