Combination of Hypoglycemia and Metformin Impairs Tumor Metabolic Plasticity and Growth by Modulating the PP2A-GSK3 beta-MCL-1 Axis

Elgendy, M; Ciro, M; Hosseini, A; Weiszmann, J; Mazzarella, L; Ferrari, E; Cazzoli, R; Curigliano, G; DeCensi, A; Bonanni, B; Budillon, A; Pelicci, PG; Janssens, V; Ogris, M; Baccarini, M; Lanfrancone, L; Weckwerth, W; Foiani, M; Minucci, S

Elgendy, M; Minucci, S (reprint author), European Inst Oncol, Dept Expt Oncol, IEO, Via Adamello 16, I-20139 Milan, Italy.; Minucci, S (reprint author), Univ Milan, Dept Biosci, I-20100 Milan, Italy.; Elgendy, M (reprint author), Univ Vienna, Ctr Pharmace

CANCER CELL, 2019; 35 (5): 798

Abstract

Tumor cells may adapt to metabolic challenges by alternating between glycolysis and oxidative phosphorylation (OXPHOS). To target this metabolic plast......

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