AR phosphorylation and CHK2 kinase activity regulates IR-stabilized AR-CHK2 interaction and prostate cancer survival

Ta, HQ; Dworak, N; Ivey, ML; Roller, DG; Gioeli, D

Gioeli, D (corresponding author), Univ Virginia, Dept Microbiol Immunol & Canc Biol, Charlottesville, VA 22903 USA.; Gioeli, D (corresponding author), Univ Virginia, Charlottesville, VA 22903 USA.

ELIFE, 2020; 9 ():

Abstract

We have previously demonstrated that checkpoint kinase 2 (CHK2) is a critical negative regulator of androgen receptor (AR) transcriptional activity, p......

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