PIG3 Regulates p53 Stability by Suppressing Its MDM2-Mediated Ubiquitination

Jin, M; Park, SJ; Kim, SW; Kim, HR; Hyun, JW; Lee, JH

Lee, JH (reprint author), Chosun Univ, Sch Med, Lab Genom Instabil & Canc Therapeut, Canc Mutat Res Ctr, Gwangju 61452, South Korea.; Lee, JH (reprint author), Chosun Univ, Sch Med, Dept Cellular & Mol Med, Gwangju 61452, South Korea.

BIOMOLECULES & THERAPEUTICS, 2017; 25 (4): 396

Abstract

Under normal, non-stressed conditions, intracellular p53 is continually ubiquitinated by MDM2 and targeted for degradation. However, in response to se......

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