Nature :研究确定类风湿关节炎40多个遗传风险基因

2014-01-02 佚名 生物谷

近日,发表在Nature杂志上的一项荟萃分析,确定了与类风湿关节炎相关的42个新的遗传基因,有助于更好地治疗自身免疫性疾病。【原文下载】 世界范围内,每一百个人中就有一人患类风湿关节炎,根据世界卫生组织的估计。大约有一半的成年人在自身免疫性疾病诊断的10年内都无法全职工作。 新研究对10万多个体基因数据进行荟萃分析,一个重要的发现是,参与心血管疾病的一些基因变异与参与癌症和类风湿关节炎的基因重

近日,发表在Nature杂志上的一项荟萃分析,确定了与类风湿关节炎相关的42个新的遗传基因,有助于更好地治疗自身免疫性疾病。【原文下载

世界范围内,每一百个人中就有一人患类风湿关节炎,根据世界卫生组织的估计。大约有一半的成年人在自身免疫性疾病诊断的10年内都无法全职工作。

新研究对10万多个体基因数据进行荟萃分析,一个重要的发现是,参与心血管疾病的一些基因变异与参与癌症和类风湿关节炎的基因重叠。

主要研究人员Siminovitch博士说:我们可以利用这些知识来找出疾病的分子途径,以及找到能有效对抗类风湿性关节炎的已有药物(例如治疗心血管疾病的药物)。此外,还可以用这个研究中的遗传信息数据开展个性化治疗。

原文出处

Yukinori Okada, Di Wu, Gosia Trynka, Towfique Raj, Chikashi Terao,Katsunori Ikari,Yuta Kochi, Koichiro Ohmura,Akari Suzuki,  Shinji Yoshida,Robert R. Graham,Arun Manoharan, Ward Ortmann,Tushar Bhangale,Joshua C. Denny,Robert J. Carroll,Anne E. Eyler, Jeffrey D. Greenberg,Joel M. Kremer,Dimitrios A. Pappas,Lei Jiang,Jian Yin,Lingying Ye, Ding-Feng Su,jian Yang et al.Genetics of rheumatoid arthritis contributes to biology and drug discovery.Nature  07 November 2013 【原文下载

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    2014-04-16 一叶知秋
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    2014-01-04 lmm397
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