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Clin Endocrinol：伽马刀用于治疗持续性肢端肥大症和库欣病

2016-05-24 MedSci MedSci原创

伽马刀肢端肥大症库欣病垂体功能减退
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伽马刀放射治疗（GKRS）常用于肢端肥大症或库欣病（CD）复发或术后残留病灶的患者。垂体功能减退是GKRS治疗后最常见的副反应。但因为缺乏相关的长期随访的研究，人们对肢端肥大症或库欣病术后垂体功能减退的危险性认识不足。本文研究人员报道了肢端肥大症或库欣病接受GKRS治疗后出现垂体功能减退的长期风险。研究人员在IRB批准的数据库中找到了从1989年到2008年在弗吉尼亚大学接受GKRS治疗的所有肢端

伽马刀放射治疗（GKRS）常用于肢端肥大症或库欣病（CD）复发或术后残留病灶的患者。垂体功能减退是GKRS治疗后最常见的副反应。但因为缺乏相关的长期随访的研究，人们对肢端肥大症或库欣病术后垂体功能减退的危险性认识不足。本文研究人员报道了肢端肥大症或库欣病接受GKRS治疗后出现垂体功能减退的长期风险。

研究人员在IRB批准的数据库中找到了从1989年到2008年在弗吉尼亚大学接受GKRS治疗的所有肢端肥大症和库欣病患者。仅有进行至少60个月内分泌随访的患者纳入研究，随访时间的中位数为159.5个月（60.1月-278月）。在GKRS治疗前及规律的随访期均需接受全面的影像学和内分泌评估。新发的垂体功能减退定义为GKRS治疗后出现的垂体激素缺乏，且需要相应的激素替代治疗。

研究纳入了60名肢端肥大症及库欣病患者。接受GKRS治疗时肿瘤体积的中位数为1.3cm2（0.3-13.4），边缘剂量的中位数为25Gy（6-30）。GKRS导致的新发垂体功能减退占所有患者的58.3%（n=35）。其中生长激素缺乏最常见（28.3%，n=17）。垂体功能减退发生在3年、5年和10年的比例分别为10%、21.7%和53.3%。GKRS术后发生垂体功能减退的时间的中位数为61个月。肿瘤侵袭海绵窦与GKRS术后垂体功能减退的新发或进展有关（P=0.018）。

放射治疗后迟发性垂体功能减退增加。根据放射敏感性的不同，激素轴的变化也不同。海绵窦有腺瘤侵及的患者在GKRS术后更易出现垂体功能的减退。

原始出处：

Cohen-Inbar O,Ramesh A,Xu A,Vance ML,Schlesinger D,Sheehan JP.Gamma Knife Radiosurgery in Patients With Persistent Acromegaly or Cushing's Disease.Clin Endocrinol. 2016;84(4):524-531.


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    2017-04-20 liuyg0228

    #持续性#

    0

  2. [GetPortalCommentsPageByObjectIdResponse(id=1922540, encodeId=cfad1922540e6, content=<a href='/topic/show?id=3f3156324ff' target=_blank style='color:#2F92EE;'>#持续性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=38, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=56324, encryptionId=3f3156324ff, topicName=持续性)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=2c31495, createdName=liuyg0228, createdTime=Thu Apr 20 03:36:00 CST 2017, time=2017-04-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1974489, encodeId=cd8a19e44897a, content=<a href='/topic/show?id=9da626115b3' target=_blank style='color:#2F92EE;'>#伽马刀#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=39, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=26115, encryptionId=9da626115b3, topicName=伽马刀)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=05202500204, createdName=minhuang75_72521584, createdTime=Sat Mar 18 15:36:00 CST 2017, time=2017-03-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=138102, encodeId=3135138102fb, content=拜读，好文, beContent=null, objectType=article, channel=null, level=null, likeNumber=83, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzdAIB7UwTkHt6fQkBP8ictliaXtc5gCUmYdAW1sAETC2nhO3q6YjRHkUibyOCtP8ibmXNObTyd63A076/0, createdBy=d4111948983, createdName=1e10c84am36(暂无匿称), createdTime=Fri Sep 30 14:42:53 CST 2016, time=2016-09-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1664758, encodeId=f3be1664e58c9, content=<a href='/topic/show?id=65b5818609b' target=_blank style='color:#2F92EE;'>#肢端肥大#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=45, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=81860, encryptionId=65b5818609b, topicName=肢端肥大)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=1cad25837873, createdName=654699882_84926994, createdTime=Sun Mar 05 07:36:00 CST 2017, time=2017-03-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=88158, encodeId=ca318815807, content=好文章，得多学习了！, beContent=null, objectType=article, channel=null, level=null, likeNumber=191, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=53751677671, createdName=沉心多思, createdTime=Thu Jun 02 02:43:00 CST 2016, time=2016-06-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=87733, encodeId=bbef8e7336c, content=值得学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=145, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=f9f21613855, createdName=lsblb, createdTime=Tue May 31 09:04:00 CST 2016, time=2016-05-31, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1271188, encodeId=569712e118885, content=<a href='/topic/show?id=391f8186168' target=_blank style='color:#2F92EE;'>#肢端肥大症#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=81861, encryptionId=391f8186168, topicName=肢端肥大症)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=d7db99, createdName=chg121, createdTime=Thu May 26 07:36:00 CST 2016, time=2016-05-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1385369, encodeId=58cc138536963, content=<a href='/topic/show?id=e38b492447d' target=_blank style='color:#2F92EE;'>#库欣病#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=49244, encryptionId=e38b492447d, topicName=库欣病)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4736501, createdName=xiaoyang_ambs, createdTime=Thu May 26 07:36:00 CST 2016, time=2016-05-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=87010, encodeId=9c968e01017, content=可以实践, beContent=null, objectType=article, channel=null, level=null, likeNumber=132, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=7cde98330, createdName=milkshark, createdTime=Wed May 25 06:43:00 CST 2016, time=2016-05-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=87009, encodeId=34e68e0094d, content=很有亮点, beContent=null, objectType=article, channel=null, level=null, likeNumber=136, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=7cde98330, createdName=milkshark, createdTime=Wed May 25 06:42:00 CST 2016, time=2016-05-25, status=1, ipAttribution=)]
    2017-03-18 minhuang75_72521584

    #伽马刀#

    0

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    2016-09-30 1e10c84am36(暂无匿称)

    拜读，好文

    0

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    2017-03-05 654699882_84926994

    #肢端肥大#

    0

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    2016-06-02 沉心多思

    好文章，得多学习了！

    0

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    2016-05-31 lsblb

    值得学习

    0

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    2016-05-26 chg121

    #肢端肥大症#

    0

  8. [GetPortalCommentsPageByObjectIdResponse(id=1922540, encodeId=cfad1922540e6, content=<a href='/topic/show?id=3f3156324ff' target=_blank style='color:#2F92EE;'>#持续性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=38, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=56324, encryptionId=3f3156324ff, topicName=持续性)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=2c31495, createdName=liuyg0228, createdTime=Thu Apr 20 03:36:00 CST 2017, time=2017-04-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1974489, encodeId=cd8a19e44897a, content=<a href='/topic/show?id=9da626115b3' target=_blank style='color:#2F92EE;'>#伽马刀#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=39, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=26115, encryptionId=9da626115b3, topicName=伽马刀)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=05202500204, createdName=minhuang75_72521584, createdTime=Sat Mar 18 15:36:00 CST 2017, time=2017-03-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=138102, encodeId=3135138102fb, content=拜读，好文, beContent=null, objectType=article, channel=null, level=null, likeNumber=83, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzdAIB7UwTkHt6fQkBP8ictliaXtc5gCUmYdAW1sAETC2nhO3q6YjRHkUibyOCtP8ibmXNObTyd63A076/0, createdBy=d4111948983, createdName=1e10c84am36(暂无匿称), createdTime=Fri Sep 30 14:42:53 CST 2016, time=2016-09-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1664758, encodeId=f3be1664e58c9, content=<a href='/topic/show?id=65b5818609b' target=_blank style='color:#2F92EE;'>#肢端肥大#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=45, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=81860, encryptionId=65b5818609b, topicName=肢端肥大)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=1cad25837873, createdName=654699882_84926994, createdTime=Sun Mar 05 07:36:00 CST 2017, time=2017-03-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=88158, encodeId=ca318815807, content=好文章，得多学习了！, beContent=null, objectType=article, channel=null, level=null, likeNumber=191, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=53751677671, createdName=沉心多思, createdTime=Thu Jun 02 02:43:00 CST 2016, time=2016-06-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=87733, encodeId=bbef8e7336c, content=值得学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=145, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=f9f21613855, createdName=lsblb, createdTime=Tue May 31 09:04:00 CST 2016, time=2016-05-31, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1271188, encodeId=569712e118885, content=<a href='/topic/show?id=391f8186168' target=_blank style='color:#2F92EE;'>#肢端肥大症#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=81861, encryptionId=391f8186168, topicName=肢端肥大症)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=d7db99, createdName=chg121, createdTime=Thu May 26 07:36:00 CST 2016, time=2016-05-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1385369, encodeId=58cc138536963, content=<a href='/topic/show?id=e38b492447d' target=_blank style='color:#2F92EE;'>#库欣病#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=49244, encryptionId=e38b492447d, topicName=库欣病)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4736501, createdName=xiaoyang_ambs, createdTime=Thu May 26 07:36:00 CST 2016, time=2016-05-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=87010, encodeId=9c968e01017, content=可以实践, beContent=null, objectType=article, channel=null, level=null, likeNumber=132, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=7cde98330, createdName=milkshark, createdTime=Wed May 25 06:43:00 CST 2016, time=2016-05-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=87009, encodeId=34e68e0094d, content=很有亮点, beContent=null, objectType=article, channel=null, level=null, likeNumber=136, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=7cde98330, createdName=milkshark, createdTime=Wed May 25 06:42:00 CST 2016, time=2016-05-25, status=1, ipAttribution=)]
    2016-05-26 xiaoyang_ambs

    #库欣病#

    0

  9. [GetPortalCommentsPageByObjectIdResponse(id=1922540, encodeId=cfad1922540e6, content=<a href='/topic/show?id=3f3156324ff' target=_blank style='color:#2F92EE;'>#持续性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=38, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=56324, encryptionId=3f3156324ff, topicName=持续性)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=2c31495, createdName=liuyg0228, createdTime=Thu Apr 20 03:36:00 CST 2017, time=2017-04-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1974489, encodeId=cd8a19e44897a, content=<a href='/topic/show?id=9da626115b3' target=_blank style='color:#2F92EE;'>#伽马刀#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=39, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=26115, encryptionId=9da626115b3, topicName=伽马刀)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=05202500204, createdName=minhuang75_72521584, createdTime=Sat Mar 18 15:36:00 CST 2017, time=2017-03-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=138102, encodeId=3135138102fb, content=拜读，好文, beContent=null, objectType=article, channel=null, level=null, likeNumber=83, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzdAIB7UwTkHt6fQkBP8ictliaXtc5gCUmYdAW1sAETC2nhO3q6YjRHkUibyOCtP8ibmXNObTyd63A076/0, createdBy=d4111948983, createdName=1e10c84am36(暂无匿称), createdTime=Fri Sep 30 14:42:53 CST 2016, time=2016-09-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1664758, encodeId=f3be1664e58c9, content=<a href='/topic/show?id=65b5818609b' target=_blank style='color:#2F92EE;'>#肢端肥大#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=45, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=81860, encryptionId=65b5818609b, topicName=肢端肥大)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=1cad25837873, createdName=654699882_84926994, createdTime=Sun Mar 05 07:36:00 CST 2017, time=2017-03-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=88158, encodeId=ca318815807, content=好文章，得多学习了！, beContent=null, objectType=article, channel=null, level=null, likeNumber=191, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=53751677671, createdName=沉心多思, createdTime=Thu Jun 02 02:43:00 CST 2016, time=2016-06-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=87733, encodeId=bbef8e7336c, content=值得学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=145, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=f9f21613855, createdName=lsblb, createdTime=Tue May 31 09:04:00 CST 2016, time=2016-05-31, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1271188, encodeId=569712e118885, content=<a href='/topic/show?id=391f8186168' target=_blank style='color:#2F92EE;'>#肢端肥大症#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=81861, encryptionId=391f8186168, topicName=肢端肥大症)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=d7db99, createdName=chg121, createdTime=Thu May 26 07:36:00 CST 2016, time=2016-05-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1385369, encodeId=58cc138536963, content=<a href='/topic/show?id=e38b492447d' target=_blank style='color:#2F92EE;'>#库欣病#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=49244, encryptionId=e38b492447d, topicName=库欣病)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4736501, createdName=xiaoyang_ambs, createdTime=Thu May 26 07:36:00 CST 2016, time=2016-05-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=87010, encodeId=9c968e01017, content=可以实践, beContent=null, objectType=article, channel=null, level=null, likeNumber=132, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=7cde98330, createdName=milkshark, createdTime=Wed May 25 06:43:00 CST 2016, time=2016-05-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=87009, encodeId=34e68e0094d, content=很有亮点, beContent=null, objectType=article, channel=null, level=null, likeNumber=136, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=7cde98330, createdName=milkshark, createdTime=Wed May 25 06:42:00 CST 2016, time=2016-05-25, status=1, ipAttribution=)]
    2016-05-25 milkshark

    可以实践

    0

  10. [GetPortalCommentsPageByObjectIdResponse(id=1922540, encodeId=cfad1922540e6, content=<a href='/topic/show?id=3f3156324ff' target=_blank style='color:#2F92EE;'>#持续性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=38, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=56324, encryptionId=3f3156324ff, topicName=持续性)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=2c31495, createdName=liuyg0228, createdTime=Thu Apr 20 03:36:00 CST 2017, time=2017-04-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1974489, encodeId=cd8a19e44897a, content=<a href='/topic/show?id=9da626115b3' target=_blank style='color:#2F92EE;'>#伽马刀#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=39, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=26115, encryptionId=9da626115b3, topicName=伽马刀)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=05202500204, createdName=minhuang75_72521584, createdTime=Sat Mar 18 15:36:00 CST 2017, time=2017-03-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=138102, encodeId=3135138102fb, content=拜读，好文, beContent=null, objectType=article, channel=null, level=null, likeNumber=83, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzdAIB7UwTkHt6fQkBP8ictliaXtc5gCUmYdAW1sAETC2nhO3q6YjRHkUibyOCtP8ibmXNObTyd63A076/0, createdBy=d4111948983, createdName=1e10c84am36(暂无匿称), createdTime=Fri Sep 30 14:42:53 CST 2016, time=2016-09-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1664758, encodeId=f3be1664e58c9, content=<a href='/topic/show?id=65b5818609b' target=_blank style='color:#2F92EE;'>#肢端肥大#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=45, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=81860, encryptionId=65b5818609b, topicName=肢端肥大)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=1cad25837873, createdName=654699882_84926994, createdTime=Sun Mar 05 07:36:00 CST 2017, time=2017-03-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=88158, encodeId=ca318815807, content=好文章，得多学习了！, beContent=null, objectType=article, channel=null, level=null, likeNumber=191, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=53751677671, createdName=沉心多思, createdTime=Thu Jun 02 02:43:00 CST 2016, time=2016-06-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=87733, encodeId=bbef8e7336c, content=值得学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=145, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=f9f21613855, createdName=lsblb, createdTime=Tue May 31 09:04:00 CST 2016, time=2016-05-31, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1271188, encodeId=569712e118885, content=<a href='/topic/show?id=391f8186168' target=_blank style='color:#2F92EE;'>#肢端肥大症#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=81861, encryptionId=391f8186168, topicName=肢端肥大症)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=d7db99, createdName=chg121, createdTime=Thu May 26 07:36:00 CST 2016, time=2016-05-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1385369, encodeId=58cc138536963, content=<a href='/topic/show?id=e38b492447d' target=_blank style='color:#2F92EE;'>#库欣病#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=49244, encryptionId=e38b492447d, topicName=库欣病)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4736501, createdName=xiaoyang_ambs, createdTime=Thu May 26 07:36:00 CST 2016, time=2016-05-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=87010, encodeId=9c968e01017, content=可以实践, beContent=null, objectType=article, channel=null, level=null, likeNumber=132, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=7cde98330, createdName=milkshark, createdTime=Wed May 25 06:43:00 CST 2016, time=2016-05-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=87009, encodeId=34e68e0094d, content=很有亮点, beContent=null, objectType=article, channel=null, level=null, likeNumber=136, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=7cde98330, createdName=milkshark, createdTime=Wed May 25 06:42:00 CST 2016, time=2016-05-25, status=1, ipAttribution=)]
    2016-05-25 milkshark

    很有亮点

    0

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