阴茎癌眼部转移一例

2018-03-17 佚名 中华眼科杂志

患者男性,43岁。因右眼疼痛伴视力下降1个月余,而于2015年1月31日入住皖南医学院附属弋矶山医院眼科。

【一般资料】

患者男性,43岁。

【主诉】

因右眼疼痛伴视力下降1个月余,而于2015年1月31日入住皖南医学院附属弋矶山医院眼科。

【现病史】

2012年11月发现外阴处一黄豆粒大小新生物,位于阴茎包皮处,后龟头变硬,尿道外口溢血伴轻度压痛,外院予包皮环切术及阴茎占位活检术,病理考虑湿疣样变,予CO2冷冻去除疣体及抗病毒治疗;后原位再次出现增生物,行浅表肿物切除术,病理示阴茎癌,2013年7月24日行阴茎癌根治切除术,病理检查结果提示阴茎高分化鳞癌,浸润肌层;后复查发现双侧腹股沟肿物,行双侧腹股沟淋巴结清扫术。以后又因左侧大腿根部皮下软组织、双侧腹股沟及髂血管旁淋巴结转移,于2014年9月29日行左下肢血管探查+带蒂肌皮瓣切除移植+左髋关节周围骨骼肌软组织肿瘤切除+腹股沟淋巴结清扫术。2015年1月13日患者因出现右眼视力下降而首次就诊眼科,MRI平扫提示右眼脉络膜转移癌。建议进一步检查,患者拒绝,后因右眼视力丧失伴眼球剧烈疼痛而入院。

【体格检查】

神志清楚,精神可,自主体位,跛行,消瘦体型,右腹股沟处及右大腿见陈旧性手术瘢痕,双肺呼吸音粗,双下肢无水肿。眼科检查:右眼无光感,左眼1.0,眼压(非接触式眼压计):右眼13.0mmHg(1mmHg=0.133kPa),左眼11.0mmHg,右眼球轻度突出,眼位居中,各方向活动度正常,角膜透明,前房深浅可,房水清,瞳孔圆,直径5mm,光反射消失,晶状体轻度混浊,玻璃体混浊,眼底视盘边界欠清,色淡,后极部视网膜下黑色隆起,视网膜脱离;左眼未见明显异常。

【辅助检查】

眼部B超示右眼球占位(考虑转移灶可能)。眼眶MRI示右侧视网膜脱离并出血,眼球外侧环壁增厚强化(图1~3)



【初步诊断

诊断为右眼球转移癌。

【治疗】

2015年2月3日在全身麻醉下行右眼球摘除术,术中见眼球完整,内、外直肌均增厚变硬,视神经增粗,长约2cm,残端受侵犯。病理检查提示眼球部转移癌(高分化鳞癌),浸润巩膜、脉络膜、视网膜、视神经及眼外(图4~6)。


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    2018-11-15 huiwelcome
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    2018-03-19 飘飘爱

    很好

    0

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    2018-03-19 dingxiaobo
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    2018-03-17 龙胆草

    学习谢谢分享

    0

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近日美国疾病预防控制中心(CDC)发布的数据显示,从2008年到2012年,在美国每年大约有39000例HPV相关的癌症被诊断。近29000例HPV相关癌症可以通过接种HPV疫苗进行预防。这句话里有几个需要弄明白的信息,什么HPV?与HPV相关的癌症有哪些?最后的关键肯定是如何去预防。对HPV做个简单介绍:人乳头瘤病毒( human papillomavirus,HPV) 是一组嗜上皮组织双链

BMC Cancer:阴茎癌淋巴结外转移预示更差的预后

研究者进行了一项荟萃分析,调查阴茎癌淋巴结外侵犯 (ENE)评估预后的重要性,以及阴茎癌患者盆腔淋巴结转移(PLNM) 情况。研究者检索了Medline、Embase、Cochrane Library、Scopus等数据库,最终纳入了1142名患者进行荟萃分析。分析数据显示,ENE患者与非ENE患者相比,癌症特异性生存(CSS)更差(HR = 1.90, 95 % CI = 1.35-2.67,

Sci Rep:多维整体分析揭示了阴茎癌驱使候选因子和生物标记

阴茎癌(PeCa)在贫穷和不发达国家中是一个显著的公共健康问题,分子数据生成和它们在阴茎癌(PeCa)中的结合仍旧没有很好的研究。最近,有研究人员利用整体方法学结合基因组范围的拷贝数变异、DNA甲基化、miRNA和mRNA表达分析对20名普通PeCa患者进行了研究分析。研究发现,排名前16个驱使候选因子具有基因组变异并且受一系列的miRNAs调控,包括了hsa-miR-31, hsa-miR-34