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JAMA：抗利尿激素联合儿茶酚胺可降低分布性休克患者治疗导致的房颤风险

2018-05-09 zhangfan MedSci原创

分布性休克房颤抗利尿激素
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研究认为，抗利尿激素联合儿茶酚胺可降低分布性休克患者治疗导致的房颤风险

近日研究人员比较了抗利尿激素+儿茶酚胺与儿茶酚胺单药对分布性休克患者治疗差异，特别是对儿茶酚胺治疗导致的房颤不良事件的影响。

本次研究为系统综述及荟萃分析，收集截止2018年2月MEDLINE， EMBASE以及 CENTRAL等数据库相关资料。研究的主要终点是房颤发病率，次要终点包括死亡率、肾脏替代治疗、心肌损伤，室性心律失常，卒中、ICU住院时间以及总住院时间。

23个临床试验，总计3088名患者纳入本次研究，患者年龄61.1岁，女性占45.3%。高质量证据表明抗利尿激素治疗可降低房颤风险（RR=0.77，风险差异为-0.06）。总体而言，抗利尿激素治疗可减少患者死亡风险（RR=0.89，调整偏倚后为0.96）；降低肾脏替代治疗风险（RR=0.74，调整偏倚后为0.70），但组间其他次要终点差异不显著。

研究认为，抗利尿激素联合儿茶酚胺可降低分布性休克患者治疗导致的房颤风险。

原始出处：


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    2019-02-21 新生儿张玉军

    #儿茶酚胺#

    0

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    2018-07-04 xiongliangxl

    #分布性休克#

    0

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    2018-05-11 清幽蓝燕yan

    什么机制呢.有没有大神分享一下

    0

  4. [GetPortalCommentsPageByObjectIdResponse(id=1687661, encodeId=fef5168e661a4, content=<a href='/topic/show?id=c72b2854039' target=_blank style='color:#2F92EE;'>#儿茶酚胺#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=41, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=28540, encryptionId=c72b2854039, topicName=儿茶酚胺)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=5cba28405593, createdName=新生儿张玉军, createdTime=Thu Feb 21 03:59:00 CST 2019, time=2019-02-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2033405, encodeId=b43020334059d, content=<a href='/topic/show?id=8aaa31e2482' target=_blank style='color:#2F92EE;'>#分布性休克#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=39, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=31724, encryptionId=8aaa31e2482, topicName=分布性休克)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=84fb152, createdName=xiongliangxl, createdTime=Wed Jul 04 11:59:00 CST 2018, time=2018-07-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=314098, encodeId=622731409885, content=什么机制呢.有没有大神分享一下, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTJHmctib8wsjB1Y0etxU20nsCbR8rZ2fpibp2STmwH2YzicIsTe9oHRGB6XIMeBqNdIvxODicmzfeQibIw/132, createdBy=82211964557, createdName=清幽蓝燕yan, createdTime=Fri May 11 09:45:55 CST 2018, time=2018-05-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1402352, encodeId=1a791402352c2, content=<a href='/topic/show?id=862e8e196a1' target=_blank style='color:#2F92EE;'>#茶#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=24, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=87196, encryptionId=862e8e196a1, topicName=茶)], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/eTyQ1TyLVfyaGrflWSd1Jw4u1F68ibicmN32DE38FjEW3zTIKeFeaMUAQsjyqaL4QZ3lRibFIzziacMz9niceznOTTw/132, createdBy=03082405249, createdName=hbwxf, createdTime=Fri May 11 05:59:00 CST 2018, time=2018-05-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1532015, encodeId=5eeb15320155c, content=<a href='/topic/show?id=b0885428229' target=_blank style='color:#2F92EE;'>#房颤风险#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=54282, encryptionId=b0885428229, topicName=房颤风险)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=6ea612304943, createdName=whmdzju, createdTime=Fri May 11 05:59:00 CST 2018, time=2018-05-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=313751, encodeId=ef02313e5189, content=学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=46, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c3da1990174, createdName=yfjms, createdTime=Thu May 10 08:07:15 CST 2018, time=2018-05-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=313522, encodeId=dc723135222f, content=已学习.谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=44, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/DYAIOgq83epNYethSTOFuykh7ZwkiarNrrfdU8aOH960q22fkgBuibicxbKg0GfawHxZLSVX3VqEdcVBxeWdKSrkQ/132, createdBy=264d1463289, createdName=ysb-1971, createdTime=Wed May 09 17:23:41 CST 2018, time=2018-05-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=313509, encodeId=bf463135091b, content=谢谢分享学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=38, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/Q3auHgzwzM4o2XVpJ6449yqDsjibydI5HnJ8MibGxNn4HZiaZib0bdfibbwoz3KQrIyN9AGxq36ZlZRNicYlPfOOWMtwgsajY6mGNFiaPclFdowjD0/0, createdBy=97bd1338592, createdName=清风拂面, createdTime=Wed May 09 15:30:31 CST 2018, time=2018-05-09, status=1, ipAttribution=)]
    2018-05-11 hbwxf

    #茶#

    0

  5. [GetPortalCommentsPageByObjectIdResponse(id=1687661, encodeId=fef5168e661a4, content=<a href='/topic/show?id=c72b2854039' target=_blank style='color:#2F92EE;'>#儿茶酚胺#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=41, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=28540, encryptionId=c72b2854039, topicName=儿茶酚胺)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=5cba28405593, createdName=新生儿张玉军, createdTime=Thu Feb 21 03:59:00 CST 2019, time=2019-02-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2033405, encodeId=b43020334059d, content=<a href='/topic/show?id=8aaa31e2482' target=_blank style='color:#2F92EE;'>#分布性休克#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=39, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=31724, encryptionId=8aaa31e2482, topicName=分布性休克)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=84fb152, createdName=xiongliangxl, createdTime=Wed Jul 04 11:59:00 CST 2018, time=2018-07-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=314098, encodeId=622731409885, content=什么机制呢.有没有大神分享一下, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTJHmctib8wsjB1Y0etxU20nsCbR8rZ2fpibp2STmwH2YzicIsTe9oHRGB6XIMeBqNdIvxODicmzfeQibIw/132, createdBy=82211964557, createdName=清幽蓝燕yan, createdTime=Fri May 11 09:45:55 CST 2018, time=2018-05-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1402352, encodeId=1a791402352c2, content=<a href='/topic/show?id=862e8e196a1' target=_blank style='color:#2F92EE;'>#茶#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=24, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=87196, encryptionId=862e8e196a1, topicName=茶)], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/eTyQ1TyLVfyaGrflWSd1Jw4u1F68ibicmN32DE38FjEW3zTIKeFeaMUAQsjyqaL4QZ3lRibFIzziacMz9niceznOTTw/132, createdBy=03082405249, createdName=hbwxf, createdTime=Fri May 11 05:59:00 CST 2018, time=2018-05-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1532015, encodeId=5eeb15320155c, content=<a href='/topic/show?id=b0885428229' target=_blank style='color:#2F92EE;'>#房颤风险#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=54282, encryptionId=b0885428229, topicName=房颤风险)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=6ea612304943, createdName=whmdzju, createdTime=Fri May 11 05:59:00 CST 2018, time=2018-05-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=313751, encodeId=ef02313e5189, content=学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=46, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c3da1990174, createdName=yfjms, createdTime=Thu May 10 08:07:15 CST 2018, time=2018-05-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=313522, encodeId=dc723135222f, content=已学习.谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=44, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/DYAIOgq83epNYethSTOFuykh7ZwkiarNrrfdU8aOH960q22fkgBuibicxbKg0GfawHxZLSVX3VqEdcVBxeWdKSrkQ/132, createdBy=264d1463289, createdName=ysb-1971, createdTime=Wed May 09 17:23:41 CST 2018, time=2018-05-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=313509, encodeId=bf463135091b, content=谢谢分享学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=38, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/Q3auHgzwzM4o2XVpJ6449yqDsjibydI5HnJ8MibGxNn4HZiaZib0bdfibbwoz3KQrIyN9AGxq36ZlZRNicYlPfOOWMtwgsajY6mGNFiaPclFdowjD0/0, createdBy=97bd1338592, createdName=清风拂面, createdTime=Wed May 09 15:30:31 CST 2018, time=2018-05-09, status=1, ipAttribution=)]
    2018-05-11 whmdzju

    #房颤风险#

    0

  6. [GetPortalCommentsPageByObjectIdResponse(id=1687661, encodeId=fef5168e661a4, content=<a href='/topic/show?id=c72b2854039' target=_blank style='color:#2F92EE;'>#儿茶酚胺#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=41, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=28540, encryptionId=c72b2854039, topicName=儿茶酚胺)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=5cba28405593, createdName=新生儿张玉军, createdTime=Thu Feb 21 03:59:00 CST 2019, time=2019-02-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2033405, encodeId=b43020334059d, content=<a href='/topic/show?id=8aaa31e2482' target=_blank style='color:#2F92EE;'>#分布性休克#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=39, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=31724, encryptionId=8aaa31e2482, topicName=分布性休克)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=84fb152, createdName=xiongliangxl, createdTime=Wed Jul 04 11:59:00 CST 2018, time=2018-07-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=314098, encodeId=622731409885, content=什么机制呢.有没有大神分享一下, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTJHmctib8wsjB1Y0etxU20nsCbR8rZ2fpibp2STmwH2YzicIsTe9oHRGB6XIMeBqNdIvxODicmzfeQibIw/132, createdBy=82211964557, createdName=清幽蓝燕yan, createdTime=Fri May 11 09:45:55 CST 2018, time=2018-05-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1402352, encodeId=1a791402352c2, content=<a href='/topic/show?id=862e8e196a1' target=_blank style='color:#2F92EE;'>#茶#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=24, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=87196, encryptionId=862e8e196a1, topicName=茶)], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/eTyQ1TyLVfyaGrflWSd1Jw4u1F68ibicmN32DE38FjEW3zTIKeFeaMUAQsjyqaL4QZ3lRibFIzziacMz9niceznOTTw/132, createdBy=03082405249, createdName=hbwxf, createdTime=Fri May 11 05:59:00 CST 2018, time=2018-05-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1532015, encodeId=5eeb15320155c, content=<a href='/topic/show?id=b0885428229' target=_blank style='color:#2F92EE;'>#房颤风险#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=54282, encryptionId=b0885428229, topicName=房颤风险)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=6ea612304943, createdName=whmdzju, createdTime=Fri May 11 05:59:00 CST 2018, time=2018-05-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=313751, encodeId=ef02313e5189, content=学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=46, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c3da1990174, createdName=yfjms, createdTime=Thu May 10 08:07:15 CST 2018, time=2018-05-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=313522, encodeId=dc723135222f, content=已学习.谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=44, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/DYAIOgq83epNYethSTOFuykh7ZwkiarNrrfdU8aOH960q22fkgBuibicxbKg0GfawHxZLSVX3VqEdcVBxeWdKSrkQ/132, createdBy=264d1463289, createdName=ysb-1971, createdTime=Wed May 09 17:23:41 CST 2018, time=2018-05-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=313509, encodeId=bf463135091b, content=谢谢分享学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=38, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/Q3auHgzwzM4o2XVpJ6449yqDsjibydI5HnJ8MibGxNn4HZiaZib0bdfibbwoz3KQrIyN9AGxq36ZlZRNicYlPfOOWMtwgsajY6mGNFiaPclFdowjD0/0, createdBy=97bd1338592, createdName=清风拂面, createdTime=Wed May 09 15:30:31 CST 2018, time=2018-05-09, status=1, ipAttribution=)]
    2018-05-10 yfjms

    学习

    0

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    2018-05-09 ysb-1971

    已学习.谢谢分享

    0

  8. [GetPortalCommentsPageByObjectIdResponse(id=1687661, encodeId=fef5168e661a4, content=<a href='/topic/show?id=c72b2854039' target=_blank style='color:#2F92EE;'>#儿茶酚胺#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=41, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=28540, encryptionId=c72b2854039, topicName=儿茶酚胺)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=5cba28405593, createdName=新生儿张玉军, createdTime=Thu Feb 21 03:59:00 CST 2019, time=2019-02-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2033405, encodeId=b43020334059d, content=<a href='/topic/show?id=8aaa31e2482' target=_blank style='color:#2F92EE;'>#分布性休克#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=39, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=31724, encryptionId=8aaa31e2482, topicName=分布性休克)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=84fb152, createdName=xiongliangxl, createdTime=Wed Jul 04 11:59:00 CST 2018, time=2018-07-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=314098, encodeId=622731409885, content=什么机制呢.有没有大神分享一下, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTJHmctib8wsjB1Y0etxU20nsCbR8rZ2fpibp2STmwH2YzicIsTe9oHRGB6XIMeBqNdIvxODicmzfeQibIw/132, createdBy=82211964557, createdName=清幽蓝燕yan, createdTime=Fri May 11 09:45:55 CST 2018, time=2018-05-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1402352, encodeId=1a791402352c2, content=<a href='/topic/show?id=862e8e196a1' target=_blank style='color:#2F92EE;'>#茶#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=24, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=87196, encryptionId=862e8e196a1, topicName=茶)], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/eTyQ1TyLVfyaGrflWSd1Jw4u1F68ibicmN32DE38FjEW3zTIKeFeaMUAQsjyqaL4QZ3lRibFIzziacMz9niceznOTTw/132, createdBy=03082405249, createdName=hbwxf, createdTime=Fri May 11 05:59:00 CST 2018, time=2018-05-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1532015, encodeId=5eeb15320155c, content=<a href='/topic/show?id=b0885428229' target=_blank style='color:#2F92EE;'>#房颤风险#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=54282, encryptionId=b0885428229, topicName=房颤风险)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=6ea612304943, createdName=whmdzju, createdTime=Fri May 11 05:59:00 CST 2018, time=2018-05-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=313751, encodeId=ef02313e5189, content=学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=46, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c3da1990174, createdName=yfjms, createdTime=Thu May 10 08:07:15 CST 2018, time=2018-05-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=313522, encodeId=dc723135222f, content=已学习.谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=44, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/DYAIOgq83epNYethSTOFuykh7ZwkiarNrrfdU8aOH960q22fkgBuibicxbKg0GfawHxZLSVX3VqEdcVBxeWdKSrkQ/132, createdBy=264d1463289, createdName=ysb-1971, createdTime=Wed May 09 17:23:41 CST 2018, time=2018-05-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=313509, encodeId=bf463135091b, content=谢谢分享学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=38, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/Q3auHgzwzM4o2XVpJ6449yqDsjibydI5HnJ8MibGxNn4HZiaZib0bdfibbwoz3KQrIyN9AGxq36ZlZRNicYlPfOOWMtwgsajY6mGNFiaPclFdowjD0/0, createdBy=97bd1338592, createdName=清风拂面, createdTime=Wed May 09 15:30:31 CST 2018, time=2018-05-09, status=1, ipAttribution=)]
    2018-05-09 清风拂面

    谢谢分享学习

    0