Immunity：食物过敏！为什么？

2015-09-28 佚名生物谷

近日，来自辛辛那提儿童医院医学中心的研究人员在国际学术期刊Immunity上发表了一项最新研究进展，他们发现了一种新的细胞类型可能在食物过敏反应的发生中发挥重要作用，这一发现或能解释为什么有些人会产生严重的过敏反应而其他人却不会。在这项研究中，研究人员发现一种新的细胞类型，他们将其称之为MMC9细胞，这种细胞可以大量产生一种炎症性免疫蛋白--IL-9，放大机体对食物的过敏

近日，来自辛辛那提儿童医院医学中心的研究人员在国际学术期刊Immunity上发表了一项最新研究进展，他们发现了一种新的细胞类型可能在食物过敏反应的发生中发挥重要作用，这一发现或能解释为什么有些人会产生严重的过敏反应而其他人却不会。

在这项研究中，研究人员发现一种新的细胞类型，他们将其称之为MMC9细胞，这种细胞可以大量产生一种炎症性免疫蛋白--IL-9，放大机体对食物的过敏应答。据研究人员所说，在此项研究之前IL-9的主要细胞来源一直成谜。

领导该项研究的Yui-Hsi Wang博士这样说道："我们的研究表明虽然机体需要一定水平的IgE来触发食物过敏反应，但其还会产生MMC9细胞导致过敏反应更加严重，如果没有这些细胞，就不会出现严重的食物过敏。"

与人类类似，不同的小鼠对食物过敏的易感性也存在不同。因此研究人员在不同遗传背景的小鼠品系中进行了研究，他们给予小鼠卵清蛋白，用于触发过敏反应。结果发现其中一些品系的小鼠体内会产生大量MMC9细胞，而另外一些品系的小鼠则不会。没有产生MMC9细胞的小鼠只会表现出轻微的过敏应答。而产生小肠MMC9细胞的小鼠均获得严重的过敏反应，并且与IgE的表达水平高低无关。

研究人员进一步研究发现MMC9细胞的产生需要2型CD4+辅助T细胞以及IL-4和STAT6的作用。MMC9细胞通过合成大量IL-9，引起肥大细胞增多症，肥大细胞会从小肠迁移到其他器官并分泌组胺和其他分子引起严重的过敏反应。

研究人员还利用过敏病人的小肠活检样本进行了分析，寻找MMC9细胞的分子特征，也发现IL-9的基因转录本及其他相关转录本表达增强。

总的来说，这项研究以小鼠为模型，发现了产生IL-9的MMC9细胞在食物过敏反应的发生过程中发挥重要作用，为开发新的食物过敏诊断和治疗策略提供了深入见解。

原文出处：

Chun-Yu Chen8, Jee-Boong Lee8,et al.Induction of Interleukin-9-Producing Mucosal Mast Cells Promotes Susceptibility to IgE-Mediated Experimental Food Allergy.Immunity.2015

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2015-10-09 12498d2fm51(暂无昵称)

#Immunity#

24 0
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2015-11-08 IIIi

抗过敏新途径

124 0
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2015-10-12 hlycom3356

这篇文章写的很好

74 0
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2015-10-12 hlycom3356

这篇文章写的很好

119 0
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2015-10-12 hlycom3356

这篇文章写的很好

121 0
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2015-10-12 hlycom3356

这篇文章写的很好

87 0
[GetPortalCommentsPageByObjectIdResponse(id=2030301, encodeId=a50120303019f, content=<a href='/topic/show?id=25079e7287' target=_blank style='color:#2F92EE;'>#Immunity#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=24, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=9772, encryptionId=25079e7287, topicName=Immunity)], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/C4Qhy5XHSe503Qbjzc1UtDR83BCv66o6P2XRedX9ohsNGa3uEVicFFk2qkuX5zBSmpicepFySBrwoYknhqMdKmtw/132, createdBy=1aca2500179, createdName=12498d2fm51(暂无昵称), createdTime=Fri Oct 09 03:23:00 CST 2015, time=2015-10-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=42825, encodeId=a455428257f, content=抗过敏新途径, beContent=null, objectType=article, channel=null, level=null, likeNumber=124, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=8aa11659262, createdName=IIIi, createdTime=Sun Nov 08 11:31:00 CST 2015, time=2015-11-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=38620, encodeId=fd54386200b, content=这篇文章写的很好, beContent=null, objectType=article, channel=null, level=null, likeNumber=74, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=332823945, createdName=hlycom3356, createdTime=Mon Oct 12 13:49:00 CST 2015, time=2015-10-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=38621, encodeId=217238621b6, content=这篇文章写的很好, beContent=null, objectType=article, channel=null, level=null, likeNumber=119, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=332823945, createdName=hlycom3356, createdTime=Mon Oct 12 13:49:00 CST 2015, time=2015-10-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=38622, encodeId=649138622e0, content=这篇文章写的很好, beContent=null, objectType=article, channel=null, level=null, likeNumber=121, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=332823945, createdName=hlycom3356, createdTime=Mon Oct 12 13:49:00 CST 2015, time=2015-10-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=38623, encodeId=46d5386238a, content=这篇文章写的很好, beContent=null, objectType=article, channel=null, level=null, likeNumber=87, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=332823945, createdName=hlycom3356, createdTime=Mon Oct 12 13:49:00 CST 2015, time=2015-10-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1416683, encodeId=92be141668333, content=<a href='/topic/show?id=27c710101804' target=_blank style='color:#2F92EE;'>#食物#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=101018, encryptionId=27c710101804, topicName=食物)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=e3a33221853, createdName=yhy100201, createdTime=Wed Sep 30 00:23:00 CST 2015, time=2015-09-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=37540, encodeId=835e3e54068, content=学习了！！期待！, beContent=null, objectType=article, channel=null, level=null, likeNumber=36, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20170803/IMG5982F7A3DBB3C1061.jpg, createdBy=0ba51605600, createdName=Jianghuiqin, createdTime=Tue Sep 29 08:52:00 CST 2015, time=2015-09-29, status=1, ipAttribution=)]
2015-09-30 yhy100201

#食物#

27 0
[GetPortalCommentsPageByObjectIdResponse(id=2030301, encodeId=a50120303019f, content=<a href='/topic/show?id=25079e7287' target=_blank style='color:#2F92EE;'>#Immunity#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=24, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=9772, encryptionId=25079e7287, topicName=Immunity)], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/C4Qhy5XHSe503Qbjzc1UtDR83BCv66o6P2XRedX9ohsNGa3uEVicFFk2qkuX5zBSmpicepFySBrwoYknhqMdKmtw/132, createdBy=1aca2500179, createdName=12498d2fm51(暂无昵称), createdTime=Fri Oct 09 03:23:00 CST 2015, time=2015-10-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=42825, encodeId=a455428257f, content=抗过敏新途径, beContent=null, objectType=article, channel=null, level=null, likeNumber=124, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=8aa11659262, createdName=IIIi, createdTime=Sun Nov 08 11:31:00 CST 2015, time=2015-11-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=38620, encodeId=fd54386200b, content=这篇文章写的很好, beContent=null, objectType=article, channel=null, level=null, likeNumber=74, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=332823945, createdName=hlycom3356, createdTime=Mon Oct 12 13:49:00 CST 2015, time=2015-10-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=38621, encodeId=217238621b6, content=这篇文章写的很好, beContent=null, objectType=article, channel=null, level=null, likeNumber=119, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=332823945, createdName=hlycom3356, createdTime=Mon Oct 12 13:49:00 CST 2015, time=2015-10-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=38622, encodeId=649138622e0, content=这篇文章写的很好, beContent=null, objectType=article, channel=null, level=null, likeNumber=121, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=332823945, createdName=hlycom3356, createdTime=Mon Oct 12 13:49:00 CST 2015, time=2015-10-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=38623, encodeId=46d5386238a, content=这篇文章写的很好, beContent=null, objectType=article, channel=null, level=null, likeNumber=87, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=332823945, createdName=hlycom3356, createdTime=Mon Oct 12 13:49:00 CST 2015, time=2015-10-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1416683, encodeId=92be141668333, content=<a href='/topic/show?id=27c710101804' target=_blank style='color:#2F92EE;'>#食物#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=101018, encryptionId=27c710101804, topicName=食物)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=e3a33221853, createdName=yhy100201, createdTime=Wed Sep 30 00:23:00 CST 2015, time=2015-09-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=37540, encodeId=835e3e54068, content=学习了！！期待！, beContent=null, objectType=article, channel=null, level=null, likeNumber=36, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20170803/IMG5982F7A3DBB3C1061.jpg, createdBy=0ba51605600, createdName=Jianghuiqin, createdTime=Tue Sep 29 08:52:00 CST 2015, time=2015-09-29, status=1, ipAttribution=)]
2015-09-29 Jianghuiqin

学习了！！期待！

36 0

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