Laryngoscope:过敏性鼻炎患者免疫治疗前后细菌性鼻微生物比较

2020-04-16 AlexYang MedSci原创

最近的研究调查了鼻窦炎患者和无鼻疾病对照的鼻微生物比较情况。基于过敏性鼻炎(AR)免疫的改变和过敏原免疫治疗(IT),研究人员评估了这些条件下鼻微生物情况。

最近的研究调查了鼻窦炎患者和无鼻疾病对照的鼻微生物比较情况。基于过敏性鼻炎(AR)免疫的改变和过敏原免疫治疗(IT),研究人员评估了这些条件下鼻微生物情况。

研究是一个代表性的比较研究,研究人员从3类群体中收集了鼻拭子用于微生物分析,包括没有进行过IT的AR患者,经历了不少于12个月IT的AR患者和健康对照组。研究人员成功的收集了14名没有进行过IT的AR患者、20名IT后AR患者和17名对照的鼻拭子。α多样性分析表明样本的均匀度存在显出差异,而丰度没有显著差异,而β多样性在不同的组之间显著不同。棒状杆菌和葡萄球菌是所有组中最常见的细菌。

最后,研究人员指出,β多样性在3个小组间存在显著不同,但是AR组与对照组更为相似。尽管经历了IT后得到系统性改善,其微生物并没有出现向健康微生物组成转变。

原始出处:

Bender ME, Read TD, Edwards TS et al. A Comparison of the Bacterial Nasal Microbiome in Allergic Rhinitis Patients and After Immunotherapy. Laryngoscope. 17 Mar 2020.

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    2020-12-22 feather89
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    2020-04-17 1902498648_44512810

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