Eur Heart J:绝经年龄与心力衰竭和房颤风险的关系

2022-08-05 MedSci原创 MedSci原创

该研究的结果表明,绝经期提前或绝经年龄较小的绝经妇女发生心衰和房颤的风险可能增加。在预防未来发生心衰和房颤的风险中需要考虑这些生殖内分泌因素。

更年期已经成为女性患心血管疾病(如心力衰竭)的一种特定危险因素。尽管既往有研究报道早期绝经与心衰发生之间存在显著的相关性,但是绝经年龄与心力衰竭和房颤发生风险之间的关联有待进一步明确。

近日,心血管领域权威杂志Eur Heart J上发表了一篇研究文章,该研究旨在探讨女性绝经期提前和绝经年龄与心力衰竭和房颤发生风险之间的关系。

该研究的对象为1401175名接受韩国国民健康保险公团健康检查的绝经后妇女。研究人员收集了她们的生育史,并采用多变量Cox比例风险模型,根据绝经期提前史和绝经年龄来确定心力衰竭和房颤发生的风险比和95%可信区间。

研究人员对受试者平均随访了9.1年,新增心力衰竭和房颤病例数量分别为42699例(3.0%)和44834例(3.2%)。与无绝经期提前史的女性相比,有过早绝经史的女性发生心力衰竭(风险比为1.33,95%可信区间为1.26-1.40)和房颤(风险比为1.09,95%可信区间为1.02-1.16)的风险更高。与绝经时年龄≥50岁的女性相比,绝经时年龄为45-49岁、40-44岁和<40岁的女性发生心力衰竭和房颤风险的风险比明显增加(P<0.001)。一系列敏感性分析结果的稳健性进一步强化了主要研究结果。

由此可见,该研究的结果表明,绝经期提前或绝经年龄较小的绝经妇女发生心衰和房颤的风险可能增加。在预防未来发生心衰和房颤的风险中需要考虑这些生殖内分泌因素。

原始出处:

Jean Shin,et al.Age at menopause and risk of heart failure and atrial fibrillation: a nationwide cohort study.European Heart Journal.2022.https://academic.oup.com/eurheartj/advance-article-abstract/doi/10.1093/eurheartj/ehac364/6646730?redirectedFrom=fulltext

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    2022-08-07 zhaojie88
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    2022-08-07 slcumt

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