Semin Arthritis Rheu:血清双酚A是高尿酸血症的独立危险因素

2018-03-19 xiangting MedSci原创

血清BPA是高尿酸血症的独立危险因素。

这项研究旨在评估血清双酚A(BPA)是否为高尿酸血症的危险因素。

在这项前瞻性研究中,基线共有482名无高尿酸血症的参与者入选并随访6年。记录临床特征,并测量血清尿酸和BPA水平。根据基线血清BPA水平低、中、高将参与者分为三分位。使用回归模型分析血清BPA与尿酸变化和高尿酸血症风险的关联。

基线时,BPA的血清浓度是0.51(0.24,2.37)ng/mL。经过6年的随访,基线BPA浓度较高的受试者血清尿酸浓度从基线至6年的变化较大(低、中、高三分位数分别为0.03±0.19,0.07±0.21和0.11±0.25 mg/dl, P = 0.006)。当根据年龄、肾功能、糖尿病高血压病史等潜在混杂因素进行调整后,多变量logistic分析显示,与低基线BPA受试者相比,中或高基线BPA受试者的6年高尿酸血症发病率高两倍[中三分位数比值比(OR)2.28(95%CI 1.05,4.95); 高三分位数2.42(1.07,5.48),P趋势 = 0.043 ]。

血清BPA是高尿酸血症的独立危险因素。

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    2018-03-21 zhaojie88
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    2018-03-19 源点

    学习了.谢谢

    0

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    2018-03-19 1e0f8808m18(暂无匿称)

    学习了.好文章.

    0

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