BMC Gastroenterology:血清甘油三酯升高和低密度脂蛋白胆固醇促进结直肠息肉的形成

2019-12-16 不详 MedSci原创

高脂血症可能是肠息肉发生的潜在危险因素。本研究旨在评估血脂异常与结直肠息肉形成之间的相关性。

背景
高脂血症可能是肠息肉发生的潜在危险因素。本研究旨在评估血脂异常与结直肠息肉形成之间的相关性。

方法
这项研究共纳入114例大肠息肉患者和48名健康对照患者。在采血前1周内对所有患者和对照进行结肠镜检查。研究使用自动生化分析仪测量患者血清脂质和脂蛋白的浓度。根据病理特征对大肠病变进行分类,并在研究中鉴定出四种类型:增生性息肉(HP),肾小管腺瘤(TA),肾小管性腺瘤(TVA)和高度不典型增生的腺瘤(A-HGD)。根据息肉的数量,大小和组织学类型对晚期腺瘤进行分类。

结果
晚期腺瘤组的低密度脂蛋白胆固醇(LDL-C)值明显高于对照组(p <0.05)。此外,与对照组相比,HP组和TA组的LDL-C值更高(p <0.05)。肥胖,年龄,TG和LDL-C升高是结直肠息肉形成的独立危险因素。区分息肉患者和健康对照组的甘油三酸酯(TG)和LDL-C的临界值为0.96 mmol / L(AUC = 0.604,p = 0.036)和3.05 mmol / L(AUC = 0.654,p = 0.002)。联合使用增加的LDL-C和TG水平来区分息肉患者是有效的,敏感性为50.0%,特异性为89.6%(AUC = 0.733,p<0.01)。

结论
结直肠息肉更常见于肥胖和老年患者。LDL-C和TG升高与息肉的发生有关。

原始出处:

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