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Nature：干扰剪接体的功能或可有效杀灭恶性癌细胞

2015-09-08 佚名 生物谷

剪接体癌细胞癌症基因MYC
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癌症通常就像是油门踏板失控的汽车一样失控驰骋在路上而无法控制，大多数新型的靶向癌症疗法都试图寻找解决癌症“油门踩踏”的问题来解决癌症的发展，但对于很多类型的癌症而言，失控的油门踏板似乎得不到修复，因此科学家们急需一种新型替代疗法，而近日一项刊登于国际杂志Nature上的研究论文中，来自贝勒医学院的科学家通过研究发现了如何抑制一些致死性癌症的新思路。研究者Thomas F. Westbrook教授表



癌症通常就像是油门踏板失控的汽车一样失控驰骋在路上而无法控制，大多数新型的靶向癌症疗法都试图寻找解决癌症“油门踩踏”的问题来解决癌症的发展，但对于很多类型的癌症而言，失控的油门踏板似乎得不到修复，因此科学家们急需一种新型替代疗法，而近日一项刊登于国际杂志Nature上的研究论文中，来自贝勒医学院的科学家通过研究发现了如何抑制一些致死性癌症的新思路。

研究者Thomas F. Westbrook教授表示，大约30%的恶性癌症都是由癌症基因MYC所驱动的，而目前并没有人可以关闭该基因的表达，而且MYC驱动的癌症患者通常会缺少有效的治疗手段；就好象造成汽车失控的情况一样，研究者已经发现了一种新型方法来杀灭由MYC驱动的癌症，而通过抑制癌细胞中剪接体的功能或许就可以有效抑制癌症的进展。

研究者指出，我们发现由MYC驱动的癌症依赖于剪接体来生存，剪接体是一种由多种蛋白质组成的复杂分子机器，其可以帮助癌症阅读剔除必要步骤后的指令，当抑制剪接体功能后，癌细胞就不再理解生长和生存的细胞指令了。这项研究中研究人员发现，利用杀灭肿瘤细胞的药物就可以实现对剪接体的抑制，但会在未受影响的小鼠机体中留下非癌变的组织。

MYC会重新连接癌细胞并且改变很多情况，比如所有肿瘤细胞需要的结构单元的产生等，但这种连接往往会给癌细胞带来新的压力及弱点，如果我们可以学会如何加剧这些压力，那么或许就可以在不伤害正常组织的情况下杀灭癌细胞。当剪接体抑制子不能够提供解决所有癌症的答案时，其或许就可以作为一种候选靶点来帮助治疗某些恶性癌症，比如三阴性乳腺癌等。

原文出处：

Tiffany Y.-T. Hsu, Lukas M. Simon,et al.The spliceosome is a therapeutic vulnerability in MYC-driven cancer.Nature.2015

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    2016-02-05 liye789132251

    #Nat#

    0

  2. [GetPortalCommentsPageByObjectIdResponse(id=1880799, encodeId=8aa61880e997f, content=<a href='/topic/show?id=3b2112532d8' target=_blank style='color:#2F92EE;'>#Nat#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=44, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=12532, encryptionId=3b2112532d8, topicName=Nat)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=2e6f107, createdName=liye789132251, createdTime=Fri Feb 05 20:02:00 CST 2016, time=2016-02-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1755353, encodeId=942a1e5535386, content=<a href='/topic/show?id=7a7232e6217' target=_blank style='color:#2F92EE;'>#剪接体#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=32762, encryptionId=7a7232e6217, topicName=剪接体)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=00cd36877321, createdName=diushouji, createdTime=Sat Apr 02 00:02:00 CST 2016, time=2016-04-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1252047, encodeId=b666125204e49, content=<a href='/topic/show?id=3efee1519b2' target=_blank style='color:#2F92EE;'>#癌细胞#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=33, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=71519, encryptionId=3efee1519b2, topicName=癌细胞)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4cea26, createdName=yxch36, createdTime=Thu Sep 10 00:02:00 CST 2015, time=2015-09-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=36468, encodeId=ea6a3646884, content=有点难,不过有意思,回去看原文！, beContent=null, objectType=article, channel=null, level=null, likeNumber=115, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20170803/IMG5982F7A3DBB3C1061.jpg, createdBy=0ba51605600, createdName=Jianghuiqin, createdTime=Tue Sep 08 12:24:00 CST 2015, time=2015-09-08, status=1, ipAttribution=)]
    2016-04-02 diushouji

    #剪接体#

    0

  3. [GetPortalCommentsPageByObjectIdResponse(id=1880799, encodeId=8aa61880e997f, content=<a href='/topic/show?id=3b2112532d8' target=_blank style='color:#2F92EE;'>#Nat#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=44, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=12532, encryptionId=3b2112532d8, topicName=Nat)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=2e6f107, createdName=liye789132251, createdTime=Fri Feb 05 20:02:00 CST 2016, time=2016-02-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1755353, encodeId=942a1e5535386, content=<a href='/topic/show?id=7a7232e6217' target=_blank style='color:#2F92EE;'>#剪接体#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=32762, encryptionId=7a7232e6217, topicName=剪接体)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=00cd36877321, createdName=diushouji, createdTime=Sat Apr 02 00:02:00 CST 2016, time=2016-04-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1252047, encodeId=b666125204e49, content=<a href='/topic/show?id=3efee1519b2' target=_blank style='color:#2F92EE;'>#癌细胞#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=33, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=71519, encryptionId=3efee1519b2, topicName=癌细胞)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4cea26, createdName=yxch36, createdTime=Thu Sep 10 00:02:00 CST 2015, time=2015-09-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=36468, encodeId=ea6a3646884, content=有点难,不过有意思,回去看原文！, beContent=null, objectType=article, channel=null, level=null, likeNumber=115, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20170803/IMG5982F7A3DBB3C1061.jpg, createdBy=0ba51605600, createdName=Jianghuiqin, createdTime=Tue Sep 08 12:24:00 CST 2015, time=2015-09-08, status=1, ipAttribution=)]
    2015-09-10 yxch36

    #癌细胞#

    0

  4. [GetPortalCommentsPageByObjectIdResponse(id=1880799, encodeId=8aa61880e997f, content=<a href='/topic/show?id=3b2112532d8' target=_blank style='color:#2F92EE;'>#Nat#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=44, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=12532, encryptionId=3b2112532d8, topicName=Nat)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=2e6f107, createdName=liye789132251, createdTime=Fri Feb 05 20:02:00 CST 2016, time=2016-02-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1755353, encodeId=942a1e5535386, content=<a href='/topic/show?id=7a7232e6217' target=_blank style='color:#2F92EE;'>#剪接体#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=32762, encryptionId=7a7232e6217, topicName=剪接体)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=00cd36877321, createdName=diushouji, createdTime=Sat Apr 02 00:02:00 CST 2016, time=2016-04-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1252047, encodeId=b666125204e49, content=<a href='/topic/show?id=3efee1519b2' target=_blank style='color:#2F92EE;'>#癌细胞#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=33, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=71519, encryptionId=3efee1519b2, topicName=癌细胞)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4cea26, createdName=yxch36, createdTime=Thu Sep 10 00:02:00 CST 2015, time=2015-09-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=36468, encodeId=ea6a3646884, content=有点难,不过有意思,回去看原文！, beContent=null, objectType=article, channel=null, level=null, likeNumber=115, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20170803/IMG5982F7A3DBB3C1061.jpg, createdBy=0ba51605600, createdName=Jianghuiqin, createdTime=Tue Sep 08 12:24:00 CST 2015, time=2015-09-08, status=1, ipAttribution=)]
    2015-09-08 Jianghuiqin

    有点难,不过有意思,回去看原文！

    0