Cell Metabolism:吃宵夜的秘密

2014-12-03 张迪 生物通

Salk研究院的研究人员再次证明,不仅是吃什么,而且什么时候吃对于健康都很重要生物通报道:现代社会充足的人工照明,电视、平板电脑和智能手机的出现,令不少成人,甚至儿童开起了夜班车,这不仅令他们消耗了更多的卡路里,也增加了吃宵夜的机会。Salk研究院最新一项研究指出,我们吃东西的时间比上个世纪的人们延长了,这导致了更多的高胆固醇、 糖尿病和肥胖症。这一研究成果公布在12月2日的Cell Metabo

Salk研究院的研究人员再次证明,不仅是吃什么,而且什么时候吃对于健康都很重要

现代社会充足的人工照明,电视、平板电脑和智能手机的出现,令不少成人,甚至儿童开起了夜班车,这不仅令他们消耗了更多的卡路里,也增加了吃宵夜的机会。

Salk研究院最新一项研究指出,我们吃东西的时间比上个世纪的人们延长了,这导致了更多的高胆固醇、 糖尿病和肥胖症。

这一研究成果公布在12月2日的Cell Metabolism杂志上,指出越来越多的证据表明,不仅是吃什么,而且什么时候吃对于我们的健康都很重要。虽然目前还不能在人体内进行干预实验,但这显然是一种可行的减肥方法,而且通过小鼠实验,也许能揭示什么是引发肥胖的首要因素。

2012年,Salk研究院的副教授Satchidananda Panda发现喂食了高脂饮食,但每天只在八个小时内饮食的小鼠,比较于全体都能饮食,食物量相同的小鼠来说,更加健康和苗条,而且这两组小鼠消耗的卡路里数量也相同。

而最新这项研究则通过进一步的实验,发现时间限制的作用机制比之前预期的要更为复杂,这将能扭转肥胖和糖尿病的动物模型。

在这一研究中,Panda研究组分析了将近400只小鼠,从正常的到肥胖的,还有各种不同类型的饮食,以及饮食时间限制长度。研究人员结果发现无论小鼠们的体重是多少,饮食的类型是什么,限制时间长度是多少,饮食时间限制都具有益处。

这些小鼠有的食用高脂肪饮食,有的只是吃果糖,但是无论如何,相比于对照组,时间限制在9-12个小时内的小鼠增加的体重最少。这个时间段主要显示在9-12小时内,如果超过了15个小时,就没有这么明显了。

同时研究人员也在周末解除禁食,给小鼠喘息的机会,让它们在这两天使用一些高脂肪食物。这些小鼠体重增加的比例也比全部采用不禁食的小鼠少。

更重要的是,对于已经患有肥胖症的小鼠来说,限制它们的饮食,使其不能在9个小时之外吃东西,也能发现小鼠的体重下降了。

利用这种新方法,也许研究人员能发展出一种新工具,进一步了解糖尿病的病理机制,Panda说。


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    2015-06-08 维他命
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    2015-01-27 guojianrong
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    2015-06-08 ljjj1053

    好好学习学习

    0

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    2015-10-04 一闲
  5. [GetPortalCommentsPageByObjectIdResponse(id=1959209, encodeId=224319592099f, content=<a href='/topic/show?id=dbe6445416' target=_blank style='color:#2F92EE;'>#CEL#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=4454, encryptionId=dbe6445416, topicName=CEL)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c3ff68, createdName=维他命, createdTime=Mon Jun 08 21:15:00 CST 2015, time=2015-06-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1887399, encodeId=98b7188e39997, content=<a href='/topic/show?id=d56611584ec' target=_blank style='color:#2F92EE;'>#Meta#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=22, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11584, encryptionId=d56611584ec, topicName=Meta)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=d8f4110, createdName=guojianrong, createdTime=Tue Jan 27 07:15:00 CST 2015, time=2015-01-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=26416, encodeId=3e6c264166c, content=好好学习学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=106, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=/v1.0.0/img/user_icon.png, createdBy=ac181616815, createdName=ljjj1053, createdTime=Mon Jun 08 17:41:00 CST 2015, time=2015-06-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1895750, encodeId=6b301895e50c4, content=<a href='/topic/show?id=4a391158248' target=_blank style='color:#2F92EE;'>#MET#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=36, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11582, encryptionId=4a391158248, topicName=MET)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=18fc139, createdName=一闲, createdTime=Sun Oct 04 13:15:00 CST 2015, time=2015-10-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1868961, encodeId=f1ae186896169, content=<a href='/topic/show?id=fd764459a8' target=_blank style='color:#2F92EE;'>#Cell#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=4459, encryptionId=fd764459a8, topicName=Cell)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=524d95, createdName=zhaozhouchifen, createdTime=Thu Oct 01 12:15:00 CST 2015, time=2015-10-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1577142, encodeId=e1bf15e714267, content=<a href='/topic/show?id=d86d1159e36' target=_blank style='color:#2F92EE;'>#Metabolism#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11597, encryptionId=d86d1159e36, topicName=Metabolism)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=1a6516392333, createdName=1249859em43(暂无昵称), createdTime=Fri Dec 05 08:15:00 CST 2014, time=2014-12-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1597921, encodeId=6ffd159e92126, content=<a href='/topic/show?id=6c6f1e62c5' target=_blank style='color:#2F92EE;'>#ABO#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=1762, encryptionId=6c6f1e62c5, topicName=ABO)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=b6c918580135, createdName=闆锋旦, createdTime=Fri Dec 05 08:15:00 CST 2014, time=2014-12-05, status=1, ipAttribution=)]
  6. [GetPortalCommentsPageByObjectIdResponse(id=1959209, encodeId=224319592099f, content=<a href='/topic/show?id=dbe6445416' target=_blank style='color:#2F92EE;'>#CEL#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=4454, encryptionId=dbe6445416, topicName=CEL)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c3ff68, createdName=维他命, createdTime=Mon Jun 08 21:15:00 CST 2015, time=2015-06-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1887399, encodeId=98b7188e39997, content=<a href='/topic/show?id=d56611584ec' target=_blank style='color:#2F92EE;'>#Meta#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=22, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11584, encryptionId=d56611584ec, topicName=Meta)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=d8f4110, createdName=guojianrong, createdTime=Tue Jan 27 07:15:00 CST 2015, time=2015-01-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=26416, encodeId=3e6c264166c, content=好好学习学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=106, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=/v1.0.0/img/user_icon.png, createdBy=ac181616815, createdName=ljjj1053, createdTime=Mon Jun 08 17:41:00 CST 2015, time=2015-06-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1895750, encodeId=6b301895e50c4, content=<a href='/topic/show?id=4a391158248' target=_blank style='color:#2F92EE;'>#MET#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=36, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11582, encryptionId=4a391158248, topicName=MET)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=18fc139, createdName=一闲, createdTime=Sun Oct 04 13:15:00 CST 2015, time=2015-10-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1868961, encodeId=f1ae186896169, content=<a href='/topic/show?id=fd764459a8' target=_blank style='color:#2F92EE;'>#Cell#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=4459, encryptionId=fd764459a8, topicName=Cell)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=524d95, createdName=zhaozhouchifen, createdTime=Thu Oct 01 12:15:00 CST 2015, time=2015-10-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1577142, encodeId=e1bf15e714267, content=<a href='/topic/show?id=d86d1159e36' target=_blank style='color:#2F92EE;'>#Metabolism#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11597, encryptionId=d86d1159e36, topicName=Metabolism)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=1a6516392333, createdName=1249859em43(暂无昵称), createdTime=Fri Dec 05 08:15:00 CST 2014, time=2014-12-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1597921, encodeId=6ffd159e92126, content=<a href='/topic/show?id=6c6f1e62c5' target=_blank style='color:#2F92EE;'>#ABO#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=1762, encryptionId=6c6f1e62c5, topicName=ABO)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=b6c918580135, createdName=闆锋旦, createdTime=Fri Dec 05 08:15:00 CST 2014, time=2014-12-05, status=1, ipAttribution=)]
  7. [GetPortalCommentsPageByObjectIdResponse(id=1959209, encodeId=224319592099f, content=<a href='/topic/show?id=dbe6445416' target=_blank style='color:#2F92EE;'>#CEL#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=4454, encryptionId=dbe6445416, topicName=CEL)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c3ff68, createdName=维他命, createdTime=Mon Jun 08 21:15:00 CST 2015, time=2015-06-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1887399, encodeId=98b7188e39997, content=<a href='/topic/show?id=d56611584ec' target=_blank style='color:#2F92EE;'>#Meta#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=22, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11584, encryptionId=d56611584ec, topicName=Meta)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=d8f4110, createdName=guojianrong, createdTime=Tue Jan 27 07:15:00 CST 2015, time=2015-01-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=26416, encodeId=3e6c264166c, content=好好学习学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=106, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=/v1.0.0/img/user_icon.png, createdBy=ac181616815, createdName=ljjj1053, createdTime=Mon Jun 08 17:41:00 CST 2015, time=2015-06-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1895750, encodeId=6b301895e50c4, content=<a href='/topic/show?id=4a391158248' target=_blank style='color:#2F92EE;'>#MET#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=36, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11582, encryptionId=4a391158248, topicName=MET)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=18fc139, createdName=一闲, createdTime=Sun Oct 04 13:15:00 CST 2015, time=2015-10-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1868961, encodeId=f1ae186896169, content=<a href='/topic/show?id=fd764459a8' target=_blank style='color:#2F92EE;'>#Cell#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=4459, encryptionId=fd764459a8, topicName=Cell)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=524d95, createdName=zhaozhouchifen, createdTime=Thu Oct 01 12:15:00 CST 2015, time=2015-10-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1577142, encodeId=e1bf15e714267, content=<a href='/topic/show?id=d86d1159e36' target=_blank style='color:#2F92EE;'>#Metabolism#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11597, encryptionId=d86d1159e36, topicName=Metabolism)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=1a6516392333, createdName=1249859em43(暂无昵称), createdTime=Fri Dec 05 08:15:00 CST 2014, time=2014-12-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1597921, encodeId=6ffd159e92126, content=<a href='/topic/show?id=6c6f1e62c5' target=_blank style='color:#2F92EE;'>#ABO#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=1762, encryptionId=6c6f1e62c5, topicName=ABO)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=b6c918580135, createdName=闆锋旦, createdTime=Fri Dec 05 08:15:00 CST 2014, time=2014-12-05, status=1, ipAttribution=)]
    2014-12-05 闆锋旦