Infection:冠状病毒病感染会降低患者外周血嗜酸性粒细胞水平

2021-10-18 MedSci原创 MedSci原创

2019 年冠状病毒病 (COVID-19) 流行至今已超过一年多,先前的研究已经发现在 COVID-19 患者存在中嗜酸性粒细胞减少症。

        2019 年冠状病毒病 (COVID-19) 流行至今已超过一年多,先前的研究已经发现在 COVID-19 患者存在中嗜酸性粒细胞减少症,但是,嗜酸性粒细胞减少症在该疾病中的作用仍有争议。因此,研究人员旨在通过这项研究探究患者的外周血嗜酸性粒细胞水平,并调查嗜酸性粒细胞减少症与 COVID-19 疾病严重程度之间是否存在关联。

 

      研究人员收集了荷兰全国确诊的COVID-19 患者的电子病历,然后根据COVID-19的临床严重程度将患者分为轻度、中度和重度组。轻度组包括无症状患者和不需要氧疗的患者。第 中度组包括接受了一些补充氧气的患者。重度组包括需要氧气并使用非重复呼吸面罩、高流量鼻氧、插管、重症监护病房住院或因 COVID-19 相关死亡的患者。淋巴细胞减少症定义为淋巴细胞计数低于 0.8×109细胞/L。嗜酸性粒细胞减少定义为嗜酸性粒细胞计数低于 0.04×109细胞/L。临床严重程度取决于所需的治疗和患者的预后结果,然后研究人员比较了三组之间的临床特征、实验室结果之间的差异。

 

      在本研究纳入的 230 名患者中,轻、中、重度组分别占纳入患者的 16.5%、45.7% 和 37.8%。所有患者平均年龄为 68 岁,63% 的患者为男性,研究人员通过回顾患者的电子病历发现所有患者的外周嗜酸性粒细胞计数均显着下降,这与 COVID-19 严重程度的增加相对应。在轻度、中度和重度组中,嗜酸性粒细胞减少患者的百分比分别为 73.7%、86.7% 和 94.3%(p=0.002)。

 

      本项研究结果证实重症 COVID-19 患者中嗜酸性粒细胞减少症的发生率明显更高,而且与新冠的严重程度正相关。

 

原始出处:

Marjella Eijmael. Et al. Coronavirus disease 2019 and peripheral blood eosinophil counts: a retrospective study. Infection.2021.

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