NEJM:2016年1起院内多药耐药球形绿脓杆菌感染流行病学调查结果

2019-01-02 zhangfan MedSci原创

研究认为S.Koreensis是一种机会性的人类病原体,它既存在于临床中心的基础设施中,又跨越时间和空间,导致与卫生保健相关的感染

相比于储水系统,管道系统导致住院患者感染风险较低。近日研究人员公布了2016年间发生的一系列院内临床单胞菌感染调查结论。

研究人员对国家卫生研究院(NIH)临床中心2006-16年鉴定的多药耐药球形绿脓杆菌(Sphingomonaskoreensis)进行了全基因组DNA测序。同时对病人病房水槽中提取的S.Koreensis进行测序,最终锁定医院蓄水池为其源头,并比较了该耐药菌与其他场所分离的耐药菌的差异。

研究发现,2016年从6个患者分离的S.koreensis,2株无相关性,但另外4株具有99.92%以上的遗传相似性,且对多种抗生素耐药。对NIH保留的Sphingomonasa临床分离物进行回顾性分析,发现其中一株克隆菌株在过去十年中的间歇性爆发。该S.Koreensis菌株中发现了独特的单核苷酸变异体,与该医院的蓄水设备有关,且该菌株与NIH分离株具有明显的遗传差异。

研究认为S.Koreensis是一种机会性的人类病原体,它既存在于临床中心的基础设施中,又跨越时间和空间,导致与卫生保健相关的感染。

原始出处:

Ryan C. Johnson et al. Investigation of a Cluster of Sphingomonas koreensis Infections.N Engl J Med, December 27, 2018.

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    2019-01-04 xugumin
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    2019-01-02 惠映实验室

    学习了,谢谢分享。

    0