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Am J Ophthalmol Case Rep：重症肌无力患者出现双侧假性核间性眼肌麻痹

2018-10-28 MedSci MedSci原创

重症肌无力患者双侧假性核间性眼肌麻痹
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美国德克萨斯州贝勒医学院医学院的McClard CK等人近日在Am J Ophthalmol Case Rep杂志上发表了一篇病例报告，他们报告了一例重症肌无力患者出现假性定位、双侧假性核间性眼肌麻痹。

美国德克萨斯州贝勒医学院医学院的McClard CK等人近日在Am J Ophthalmol Case Rep杂志上发表了一篇病例报告，他们报告了一例重症肌无力患者出现假性定位、双侧假性核间性眼肌麻痹。

一名61岁的男性患者，患有无痛性双眼斜视复发病史，同时伴有疲劳、声带嘶哑和双侧眼睑下垂的症状。检测发现，患者具有明显的双侧核间眼肌麻痹（INO）。脑和头颈部的MRA、MRI等检查在正常范围内。实验室研究发现，该患者对AChR结合、阻断和调节的抗体都呈阳性，对抗条纹肌肉和肌动蛋白的抗体也呈阳性。因此，该患者被诊断为重症肌无力患者。

因此，他们认为，虽然重症肌无力患者通常表现为上眼睑下垂或复视，但很少有患者发展为眼外肌无力导致的假性INO。真正的INO是发生在内侧的纵束肌肉损伤，这条肌肉纤维束控制着眼球水平运动。作者建议，当排除INO的常见病因时，临床医生应该进一步考虑与重症肌无力相关的INO的诊断指标。

原文出处：

McClard， C.K.， L.J. Lyons， and S. Yalamanchili， Bilateral pseudo-internuclear ophthalmoplegia in a patient with myasthenia gravis. Am J Ophthalmol Case Rep， 2018. 12： p. 76-78.

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    2019-01-25 aliceclz

    #重症肌无力患者#

    0

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    2019-08-25 charl1234567

    #case#

    0

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    2018-10-30 zhouqu_8

    #肌无力#

    0

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    2018-10-30 wangbingxhy

    #双侧#

    0

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    2018-10-30 1249842em13(暂无昵称)

    #THA#

    0

  6. [GetPortalCommentsPageByObjectIdResponse(id=2042394, encodeId=dde32042394bf, content=<a href='/topic/show?id=734e959e1b7' target=_blank style='color:#2F92EE;'>#重症肌无力患者#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=24, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=95971, encryptionId=734e959e1b7, topicName=重症肌无力患者)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=bfa6343, createdName=aliceclz, createdTime=Fri Jan 25 22:15:00 CST 2019, time=2019-01-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2027952, encodeId=01d8202e952a4, content=<a href='/topic/show?id=7c9a41324e' target=_blank style='color:#2F92EE;'>#case#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=4132, encryptionId=7c9a41324e, topicName=case)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=62a7397, createdName=charl1234567, createdTime=Sun Aug 25 10:15:00 CST 2019, time=2019-08-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1436660, encodeId=310c1436660c2, content=<a href='/topic/show?id=e7c18092578' target=_blank style='color:#2F92EE;'>#肌无力#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=80925, encryptionId=e7c18092578, topicName=肌无力)], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/aLGWoFXAyMbIu3qymFOyheQLjPSX3OUs5GmkyBlcCOwTPIeq3why9NGibxxUqYo6hcx8qZLHZFgNPnBK1yzWeOFpyg2OnWOt0/0, createdBy=fa4716, createdName=zhouqu_8, createdTime=Tue Oct 30 12:15:00 CST 2018, time=2018-10-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1522420, encodeId=b3e7152242096, content=<a href='/topic/show?id=46223e39897' target=_blank style='color:#2F92EE;'>#双侧#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=37398, encryptionId=46223e39897, topicName=双侧)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=741b11453403, createdName=wangbingxhy, createdTime=Tue Oct 30 12:15:00 CST 2018, time=2018-10-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1541404, encodeId=9de915414049d, content=<a href='/topic/show?id=5c961e37307' target=_blank style='color:#2F92EE;'>#THA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=17373, encryptionId=5c961e37307, topicName=THA)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=615b13300589, createdName=1249842em13(暂无昵称), createdTime=Tue Oct 30 12:15:00 CST 2018, time=2018-10-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1624901, encodeId=608c1624901d8, content=<a href='/topic/show?id=0333412062' target=_blank style='color:#2F92EE;'>#Cas#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=23, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=4120, encryptionId=0333412062, topicName=Cas)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=411420689333, createdName=yaanren, createdTime=Tue Oct 30 12:15:00 CST 2018, time=2018-10-30, status=1, ipAttribution=)]
    2018-10-30 yaanren

    #Cas#

    0