JACC:血清氯对急性失代偿性心力衰竭患者的预后作用

2015-08-04 MedSci MedSci原创

    急性失代偿性心脏衰竭(ADHF)由于电解质异常而变得复杂,但主要焦点一直集中在血清钠水平的临床意义。本研究试图确定在ADHF患者中与血清钠水平相关的血清氯水平的预后意义。    研究人员回顾了在2008年7月和2013年12月之间在克利夫兰诊所就诊的连续的1318例慢性心脏衰竭入院被确认为ADHF的患者,研究人员还从宾夕法尼亚大学的一个独立的ADHF

急性失代偿性心脏衰竭(ADHF)由于电解质异常而变得复杂,但主要焦点一直集中在血清钠水平的临床意义。本研究试图确定在ADHF患者中与血清钠水平相关的血清氯水平的预后意义。

研究人员回顾了在2008年7月和2013年12月之间在克利夫兰诊所就诊的连续的1318例因慢性心脏衰竭入院被确认为ADHF的患者,研究人员还通过宾夕法尼亚大学的一个独立的ADHF队列(n=876)证实了他们的研究结果。

实验结果:ADHF住院期间,入院时血清氯水平与长期死亡率是独立负相关的(每单位变化的风险比[HR]:0.94;95%置信区间(Cl):0.92〜0.95;P<0.001)。多变量风险调整后,相比于入院时钠水平,入院时血清氯水平仍然与死亡率保持独立(每单位变化的HR:0.93;95%Cl:0.90〜0.97;P<0.001),这种联系不再显著(P>0.05)。结果在未调整中验证队列(1年以内死亡风险每单位变化的HR:0.93;95%Cl:0.91〜0.95;P<0.001)和多变量风险调整分析中(1年以内死亡风险每单位变化的HR:0.95;95%Cl:0.92〜0.99;P=0.01),结果是类似的。

在当代先进ADHF队列的这些观察结果表明,入院时血清氯水平与死亡率独立负相关。相比于血清氯水平,血清钠在ADHF中的预后价值变小了。

原始出处:

Justin L. Grodin,Jennifer Simon,Rory Hachamovitch,Yuping Wu,Gregory Jackson,Meghana Halkar,Randall C. Starling,Jeffrey M. Testani,W.H. Wilson Tang.Prognostic Role of Serum Chloride Levels in Acute Decompensated Heart Failure,JACC,2015,8,4

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  1. [GetPortalCommentsPageByObjectIdResponse(id=1853385, encodeId=7de4185338510, content=<a href='/topic/show?id=48351020537' target=_blank style='color:#2F92EE;'>#JACC#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=10205, encryptionId=48351020537, topicName=JACC)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=55ce62, createdName=hbwxf, createdTime=Mon May 30 03:05:00 CST 2016, time=2016-05-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=35305, encodeId=e13b35305aa, content=这也可以,厉害, beContent=null, objectType=article, channel=null, level=null, likeNumber=138, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=ed101627734, createdName=Messichen1992, createdTime=Sat Aug 08 19:12:00 CST 2015, time=2015-08-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1325077, encodeId=8a1b13250e722, content=<a href='/topic/show?id=96c71804b7' target=_blank style='color:#2F92EE;'>#ACC#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=1804, encryptionId=96c71804b7, topicName=ACC)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=1e452500029, createdName=12498568m50暂无昵称, createdTime=Thu Aug 06 12:05:00 CST 2015, time=2015-08-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=34437, encodeId=600b3443e40, content=很有价值, beContent=null, objectType=article, channel=null, level=null, likeNumber=49, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=332823945, createdName=hlycom3356, createdTime=Wed Aug 05 10:24:00 CST 2015, time=2015-08-05, status=1, ipAttribution=)]
    2016-05-30 hbwxf
  2. [GetPortalCommentsPageByObjectIdResponse(id=1853385, encodeId=7de4185338510, content=<a href='/topic/show?id=48351020537' target=_blank style='color:#2F92EE;'>#JACC#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=10205, encryptionId=48351020537, topicName=JACC)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=55ce62, createdName=hbwxf, createdTime=Mon May 30 03:05:00 CST 2016, time=2016-05-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=35305, encodeId=e13b35305aa, content=这也可以,厉害, beContent=null, objectType=article, channel=null, level=null, likeNumber=138, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=ed101627734, createdName=Messichen1992, createdTime=Sat Aug 08 19:12:00 CST 2015, time=2015-08-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1325077, encodeId=8a1b13250e722, content=<a href='/topic/show?id=96c71804b7' target=_blank style='color:#2F92EE;'>#ACC#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=1804, encryptionId=96c71804b7, topicName=ACC)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=1e452500029, createdName=12498568m50暂无昵称, createdTime=Thu Aug 06 12:05:00 CST 2015, time=2015-08-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=34437, encodeId=600b3443e40, content=很有价值, beContent=null, objectType=article, channel=null, level=null, likeNumber=49, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=332823945, createdName=hlycom3356, createdTime=Wed Aug 05 10:24:00 CST 2015, time=2015-08-05, status=1, ipAttribution=)]
    2015-08-08 Messichen1992

    这也可以,厉害

    0

  3. [GetPortalCommentsPageByObjectIdResponse(id=1853385, encodeId=7de4185338510, content=<a href='/topic/show?id=48351020537' target=_blank style='color:#2F92EE;'>#JACC#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=10205, encryptionId=48351020537, topicName=JACC)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=55ce62, createdName=hbwxf, createdTime=Mon May 30 03:05:00 CST 2016, time=2016-05-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=35305, encodeId=e13b35305aa, content=这也可以,厉害, beContent=null, objectType=article, channel=null, level=null, likeNumber=138, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=ed101627734, createdName=Messichen1992, createdTime=Sat Aug 08 19:12:00 CST 2015, time=2015-08-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1325077, encodeId=8a1b13250e722, content=<a href='/topic/show?id=96c71804b7' target=_blank style='color:#2F92EE;'>#ACC#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=1804, encryptionId=96c71804b7, topicName=ACC)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=1e452500029, createdName=12498568m50暂无昵称, createdTime=Thu Aug 06 12:05:00 CST 2015, time=2015-08-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=34437, encodeId=600b3443e40, content=很有价值, beContent=null, objectType=article, channel=null, level=null, likeNumber=49, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=332823945, createdName=hlycom3356, createdTime=Wed Aug 05 10:24:00 CST 2015, time=2015-08-05, status=1, ipAttribution=)]
  4. [GetPortalCommentsPageByObjectIdResponse(id=1853385, encodeId=7de4185338510, content=<a href='/topic/show?id=48351020537' target=_blank style='color:#2F92EE;'>#JACC#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=10205, encryptionId=48351020537, topicName=JACC)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=55ce62, createdName=hbwxf, createdTime=Mon May 30 03:05:00 CST 2016, time=2016-05-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=35305, encodeId=e13b35305aa, content=这也可以,厉害, beContent=null, objectType=article, channel=null, level=null, likeNumber=138, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=ed101627734, createdName=Messichen1992, createdTime=Sat Aug 08 19:12:00 CST 2015, time=2015-08-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1325077, encodeId=8a1b13250e722, content=<a href='/topic/show?id=96c71804b7' target=_blank style='color:#2F92EE;'>#ACC#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=1804, encryptionId=96c71804b7, topicName=ACC)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=1e452500029, createdName=12498568m50暂无昵称, createdTime=Thu Aug 06 12:05:00 CST 2015, time=2015-08-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=34437, encodeId=600b3443e40, content=很有价值, beContent=null, objectType=article, channel=null, level=null, likeNumber=49, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=332823945, createdName=hlycom3356, createdTime=Wed Aug 05 10:24:00 CST 2015, time=2015-08-05, status=1, ipAttribution=)]
    2015-08-05 hlycom3356

    很有价值

    0