Amino Acids:口服营养补充剂可防止体重减轻并减少晚期肺癌化疗患者的副作用

2020-02-19 不详 网络

癌症患者的体重减轻是由癌症恶病质和化疗引起的恶心和呕吐引起的。止吐药的最新发展已大大改善了恶心和呕吐,但这种干预措施并未减轻体重减轻和化疗带来的其他更严重的副作用,例如厌食,虚弱,咳嗽,呼吸困难,咯血和疼痛。本研究旨在研究在晚期非鳞状非小细胞肺癌(NSCLC)患者化疗期间营养补充食品的干预作用。患者接受注册营养师的个性化营养咨询,并接受90天口服Texidrofolico®补充。在基线和干预90天

癌症患者的体重减轻是由癌症恶病质和化疗引起的恶心和呕吐引起的。止吐药的最新发展已大大改善了恶心和呕吐,但这种干预措施并未减轻体重减轻和化疗带来的其他更严重的副作用,例如厌食,虚弱,咳嗽,呼吸困难,咯血和疼痛。本研究旨在研究在晚期非鳞状非小细胞肺癌NSCLC)患者化疗期间营养补充食品的干预作用。

患者接受注册营养师的个性化营养咨询,并接受90天口服Texidrofolico®补充。在基线和干预90天后评估体重和上述其他副作用。为了评估这种膳食补充剂的作用,回顾性纳入了30例患者作为对照,并将体重和化疗副作用的变化与30例接受Texidrofolico®治疗的患者进行了比较。

结果显示,经过90天的干预后,通过口服Texidrofolico®,在细胞毒性化学疗法过程中,患者的生活质量得到了改善,体重和BMI的下降均不如对照组。此外,用Texidrofolico®治疗90天后,维持或增加体重的患者人数明显高于对照组。还从代谢的观点研究了用食物补充剂治疗的效果。有可能发现治疗后肿瘤生长的已知标志物之一,血浆多胺减少了。讨论了这些生物胺与叶酸循环之间的可能关系。

总之,在NSCLC患者化疗期间,早期口服Texidrofolico®强化营养干预可防止体重减轻,并且对他们的生活质量有益。

原始出处:

Torricelli P, Antonelli F, et al., Oral nutritional supplement prevents weight loss and reduces side effects in patients in advanced lung cancer chemotherapy. Amino Acids. 2020 Feb 7. doi: 10.1007/s00726-020-02822-7.

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    2020-09-21 wodejia-dayu
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    2020-03-12 docwu2019
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