DDW 2016:对乙酰氨基酚所致的急性肝损伤和急性肝衰竭更多见于女性

2016-05-23 Seven L 译 MedSci原创

消化疾病周2016(DDW)称,虽然对乙酰氨基酚引起的急性肝损伤和急性肝衰竭比例在女性中比例高于男性,但是女性的生存结果并不会更差。加州大学的Jessica Rubin博士和同事对2000-2015年间加入美国急性肝衰竭研究小组的患者数据进行了分析,共涉及1066名患者,其中有202名患者是急性肝损伤,864名患者为急性肝衰竭。而接下来要谈的结果是针对这864名急性肝衰竭患者的数据分析,其中有65

消化疾病周2016(DDW)称,虽然对乙酰氨基酚引起的急性肝损伤和急性肝衰竭比例在女性中的比例高于男性,但是女性的生存结果并不会更差。

加州大学的Jessica Rubin博士和同事对2000-2015年间加入美国急性肝衰竭研究小组的患者数据进行了分析,共涉及1066名患者,其中有202名患者是急性肝损伤,864名患者为急性肝衰竭。而接下来要谈的结果是针对这864名急性肝衰竭患者的数据分析,其中有654名为女性,210名为男性。

对乙酰氨基酚引起的急性肝衰竭女性和男性患者的发病中位数年龄分别为37和33岁(P < .001)。共病精神疾病在女性患者中更常见(60% vs. 47%,P = .009),但是因为自杀而服用对乙酰氨基酚方面不存在性别差异。女性和男性患者的中位数ALT分别为3430和4701(P = .018),入院时中位数MELD分别为32和35(P < .001)。女性插管率和使用甘露醇的比例更高,女性和男性患者的脑病发生率分别为59%和42%。需要肾替代治疗的发生率没有性别差异。

尽管对乙酰氨基酚引起的急性肝衰竭会导致更严重的多器官疾病,但是女性和男性患者的21天生存率分别为77%和74%(P = .57),此外无移植生存率也没有性别差异(68% vs. 67%,P = .63)。

“女性更容易出现对乙酰氨基酚引起的急性肝损伤和急性肝衰竭,”Rubin说,“因此,女性比男性在入院和住院治疗上需要更重要的护理。然而两性之间的整体生存或无移植生存方面并没有差异。”

原始出处:

Rubin J, et al. Abstract 352. Presented at: Digestive Diseases Week; May 21-24, 2016; San Diego, CA.  

Acetaminophen-induced acute liver injury, acute liver failure occurs more in women.Healio.May 23, 2016


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    2016-05-25 aids214

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