糖尿病

订阅

MedSci主页 / 所有栏目 / 糖尿病

Oncotarget：维生素D缺乏通过激发肝细胞中的氧化应激引起胰岛素抵抗

2017-07-11 Emma MedSci原创

胰岛素抵抗维生素DN-乙酰半胱氨酸肝细胞氧化应激
关注

胰岛素抵抗是指各种原因使胰岛素促进葡萄糖摄取和利用的效率下降，机体代偿性的分泌过多胰岛素产生高胰岛素血症，以维持血糖的稳定。胰岛素抵抗易导致代谢综合征和2型糖尿病。研究表明，维生素D缺乏可导致胰岛素抵抗。维生素D3是维生素D在人体内主要的活性形式，1α-羟化酶是激活维生素D3合成的关键酶。发表于Oncotarget的一篇文章中，研究人员发现，维生素D缺乏诱导的胰岛素抵抗与肝细胞氧化应激有关。

胰岛素抵抗是指各种原因使胰岛素促进葡萄糖摄取和利用的效率下降，机体代偿性的分泌过多胰岛素产生高胰岛素血症，以维持血糖的稳定。胰岛素抵抗易导致代谢综合征和2型糖尿病。研究表明，维生素D缺乏可导致胰岛素抵抗。维生素D3是维生素D在人体内主要的活性形式，1α-羟化酶是激活维生素D3合成的关键酶。发表于Oncotarget的一篇文章中，研究人员发现，维生素D缺乏诱导的胰岛素抵抗与肝细胞氧化应激有关。在L02肝细胞中，通过shRNA抑制1α-羟化酶表达后，维生素D3出现耗竭，同时胰岛素诱导的下游信号（IRS-1、ERK和Akt）通路转导和和葡萄糖转运蛋白4表达也受到了抑制。L02肝细胞中的1α-羟化酶shRNA还导致了活性氧的显著生成，p53-p21激活和DNA损伤。N-乙酰半胱氨酸（NAC）是一种已知抗氧化剂，经过N-乙酰半胱氨酸处理后，1α-羟化酶shRNA对L02肝细胞的这种影响几乎可以被完全消除，并且其中值得注意的是，胰岛素诱导的下游信号转导和葡萄糖转运蛋白4表达所受到的影响也被恢复。原始出处：Tao S, et al. Vitamin D deficiency causes insul

版权声明：
本网站所有内容来源注明为“梅斯医学”或“MedSci原创”的文字、图片和音视频资料，版权均属于梅斯医学所有。非经授权，任何媒体、网站或个人不得转载，授权转载时须注明来源为“梅斯医学”。其它来源的文章系转载文章，或“梅斯号”自媒体发布的文章，仅系出于传递更多信息之目的，本站仅负责审核内容合规，其内容不代表本站立场，本站不负责内容的准确性和版权。如果存在侵权、或不希望被转载的媒体或个人可与我们联系，我们将立即进行删除处理。
在此留言
评论区 (4)
#插入话题
  1. [GetPortalCommentsPageByObjectIdResponse(id=1749783, encodeId=91a31e49783a9, content=<a href='/topic/show?id=be7c8385345' target=_blank style='color:#2F92EE;'>#胰岛#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=83853, encryptionId=be7c8385345, topicName=胰岛)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=a7a536274692, createdName=baoya, createdTime=Mon May 21 22:31:00 CST 2018, time=2018-05-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1795381, encodeId=57451e95381ac, content=<a href='/topic/show?id=248e1e1345b' target=_blank style='color:#2F92EE;'>#target#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=46, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=17134, encryptionId=248e1e1345b, topicName=target)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=8409354, createdName=闆锋旦, createdTime=Wed Jul 12 02:31:00 CST 2017, time=2017-07-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1863289, encodeId=1ede1863289ac, content=<a href='/topic/show?id=c0b68135561' target=_blank style='color:#2F92EE;'>#肝细胞#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=42, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=81355, encryptionId=c0b68135561, topicName=肝细胞)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=d59291, createdName=xjy02, createdTime=Mon Jun 04 07:31:00 CST 2018, time=2018-06-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1445167, encodeId=cb29144516ea1, content=<a href='/topic/show?id=61e74928629' target=_blank style='color:#2F92EE;'>#应激#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=49286, encryptionId=61e74928629, topicName=应激)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4c37265, createdName=医者仁心, createdTime=Thu Jul 13 14:31:00 CST 2017, time=2017-07-13, status=1, ipAttribution=)]
    2018-05-21 baoya

    #胰岛#

    0

  2. [GetPortalCommentsPageByObjectIdResponse(id=1749783, encodeId=91a31e49783a9, content=<a href='/topic/show?id=be7c8385345' target=_blank style='color:#2F92EE;'>#胰岛#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=83853, encryptionId=be7c8385345, topicName=胰岛)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=a7a536274692, createdName=baoya, createdTime=Mon May 21 22:31:00 CST 2018, time=2018-05-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1795381, encodeId=57451e95381ac, content=<a href='/topic/show?id=248e1e1345b' target=_blank style='color:#2F92EE;'>#target#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=46, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=17134, encryptionId=248e1e1345b, topicName=target)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=8409354, createdName=闆锋旦, createdTime=Wed Jul 12 02:31:00 CST 2017, time=2017-07-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1863289, encodeId=1ede1863289ac, content=<a href='/topic/show?id=c0b68135561' target=_blank style='color:#2F92EE;'>#肝细胞#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=42, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=81355, encryptionId=c0b68135561, topicName=肝细胞)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=d59291, createdName=xjy02, createdTime=Mon Jun 04 07:31:00 CST 2018, time=2018-06-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1445167, encodeId=cb29144516ea1, content=<a href='/topic/show?id=61e74928629' target=_blank style='color:#2F92EE;'>#应激#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=49286, encryptionId=61e74928629, topicName=应激)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4c37265, createdName=医者仁心, createdTime=Thu Jul 13 14:31:00 CST 2017, time=2017-07-13, status=1, ipAttribution=)]
    2017-07-12 闆锋旦

    #target#

    0

  3. [GetPortalCommentsPageByObjectIdResponse(id=1749783, encodeId=91a31e49783a9, content=<a href='/topic/show?id=be7c8385345' target=_blank style='color:#2F92EE;'>#胰岛#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=83853, encryptionId=be7c8385345, topicName=胰岛)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=a7a536274692, createdName=baoya, createdTime=Mon May 21 22:31:00 CST 2018, time=2018-05-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1795381, encodeId=57451e95381ac, content=<a href='/topic/show?id=248e1e1345b' target=_blank style='color:#2F92EE;'>#target#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=46, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=17134, encryptionId=248e1e1345b, topicName=target)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=8409354, createdName=闆锋旦, createdTime=Wed Jul 12 02:31:00 CST 2017, time=2017-07-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1863289, encodeId=1ede1863289ac, content=<a href='/topic/show?id=c0b68135561' target=_blank style='color:#2F92EE;'>#肝细胞#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=42, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=81355, encryptionId=c0b68135561, topicName=肝细胞)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=d59291, createdName=xjy02, createdTime=Mon Jun 04 07:31:00 CST 2018, time=2018-06-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1445167, encodeId=cb29144516ea1, content=<a href='/topic/show?id=61e74928629' target=_blank style='color:#2F92EE;'>#应激#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=49286, encryptionId=61e74928629, topicName=应激)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4c37265, createdName=医者仁心, createdTime=Thu Jul 13 14:31:00 CST 2017, time=2017-07-13, status=1, ipAttribution=)]
    2018-06-04 xjy02

    #肝细胞#

    0

  4. [GetPortalCommentsPageByObjectIdResponse(id=1749783, encodeId=91a31e49783a9, content=<a href='/topic/show?id=be7c8385345' target=_blank style='color:#2F92EE;'>#胰岛#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=83853, encryptionId=be7c8385345, topicName=胰岛)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=a7a536274692, createdName=baoya, createdTime=Mon May 21 22:31:00 CST 2018, time=2018-05-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1795381, encodeId=57451e95381ac, content=<a href='/topic/show?id=248e1e1345b' target=_blank style='color:#2F92EE;'>#target#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=46, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=17134, encryptionId=248e1e1345b, topicName=target)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=8409354, createdName=闆锋旦, createdTime=Wed Jul 12 02:31:00 CST 2017, time=2017-07-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1863289, encodeId=1ede1863289ac, content=<a href='/topic/show?id=c0b68135561' target=_blank style='color:#2F92EE;'>#肝细胞#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=42, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=81355, encryptionId=c0b68135561, topicName=肝细胞)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=d59291, createdName=xjy02, createdTime=Mon Jun 04 07:31:00 CST 2018, time=2018-06-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1445167, encodeId=cb29144516ea1, content=<a href='/topic/show?id=61e74928629' target=_blank style='color:#2F92EE;'>#应激#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=49286, encryptionId=61e74928629, topicName=应激)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4c37265, createdName=医者仁心, createdTime=Thu Jul 13 14:31:00 CST 2017, time=2017-07-13, status=1, ipAttribution=)]
    2017-07-13 医者仁心

    #应激#

    0

相关资讯

Diabetes：SIRT6能阻止肥胖相关的组织炎症和胰岛素抵抗进展

肥胖相关的胰岛素抵抗与巨噬细胞聚集和随后局部组织中细胞因子的释放密切相关。Sirtuin（SIRT）6是沉默信息调节蛋白家族成员之一，是一种依赖于烟酰胺腺嘌呤二核苷酸(NAD+)的组蛋白去乙酰化酶及ADP-核糖基转移酶的蛋白酶。

JCEM：胰岛素抵抗与处于骨峰值的非糖尿病人的骨密质大小有关

在这群非糖尿病人的骨峰值期，胰岛素抵抗与小梁骨和骨密质大小成反比。在调整了身体成分、肌肉大小或功能或性类固醇水平后，这些关联仍持续存在，这表明胰岛素抵抗对骨骼几何结构的影响是独立的。

Diabetes Obes Metab：红酒多酚并不能改善肥胖相关的胰岛素抵抗！

这项研究表明八周的RWPs补充并不能改善肥胖者胰岛素敏感性。该研究结果与RWPs能改善肥胖人群胰岛素抵抗的假设不一致。

Diabetes Obes Metab：Bimagrumab可以改善身胰岛素抵抗者的身体成分和胰岛素敏感性！

将这些观察到的变化放在一起考虑，在这些发生不伴有饮食干预和没有进行任何定期的体育锻炼的患者，Bimagrumab可能为肥胖代谢并发症的治疗提供了新方法。

Neurology：中年肥胖患者胰岛素抵抗与脑血管反应性降低相关！

由此可见，IR与CVR下降相关；这种相关性似乎是由IR程度所驱动，而不是肥胖。这些很少报道的结果表明肥胖的具有显著IR而不是2型糖尿病患者的中年人中存在明显的脑血管功能障碍。这些功能性的血管异常可能有助于解释IR、糖尿病和老年痴呆症之间的相关性，并建议以改善IR或CVR干预可能有助于预防晚期生活的认知下降。

Diabetes Obes Metab：利拉鲁肽对膳食脂质诱导的胰岛素抵抗的影响！

由此可见，利拉鲁肽能够减弱富含SFA饮食诱导的胰岛素抵抗。这种效应可能与改善微血管功能和调节骨骼肌中的TxNIP和AMPK通路相关。