Neurology:孤立性肌张力障碍患者的自杀行为发生率明显增加

2021-02-01 Freeman MedSci原创

孤立性肌张力障碍患者的自杀行为发生率明显增加

 

孤立性肌张力障碍是仅次于特发性震颤和帕金森病的第三大运动障碍,在普通人群中每10万人中有3-30人受到影响。一些研究已经确定,除了使人衰弱的运动症状外,高达90%的肌张力障碍患者还合并有精神疾病,最常见的包括广泛性或社交焦虑、强迫症和重度抑郁症。这些精神疾病一直被认为是自杀的最重要的风险因素之一,而自杀是全球死亡的主要原因。

然而,肌张力障碍患者,尤其是那些容易出现精神合并症的患者,其自杀意念和行为的发生率尚不清楚。

藉此,考虑到围绕自杀的耻辱感和有自杀倾向的人倾向于避免临床干预,我们推测肌张力障碍患者的自杀行为可能在常规神经学评估中未被披露,进一步增加了这些患者的自杀风险。我们进行了一项匿名电子调查研究,调查了542名不同形式的孤立性肌张力障碍患者的人口统计学和自杀率及其与共存精神疾病的关系。

哈佛医学院的Alexis Worthley等人探究了了孤立性肌张力障碍患者自杀行为风险是否会增加。

他们纳入了542名肌张力障碍患者,并让其完成了97个问题的在线调查,该调查收集了这些患者的自杀行为和主要精神障碍的人口统计资料。
统计分析了肌张力障碍患者自杀行为的流行率与全球普通人群自杀意念和企图的流行率的比较,并评估了这些患者自杀性和精神病史之间风险关联的意义。

结果显示,有32.3%的肌张力障碍患者有自杀倾向。总体而言,32.3%的孤立性肌张力障碍患者报告了自杀行为史,这与全球普通人群中报告的自杀意念(9.2%)和企图(2.7%)的比例有显著差异。

与局灶性肌张力障碍患者(范围为26.1%-33.3%)相比,多灶性/节段性和全身性肌张力障碍患者的自杀率更高(范围为46%-50%)。全身性肌张力障碍患者的自杀意念与企图比最高,为4:1。局灶性肌张力症患者的自杀行为与其抑郁症和焦虑症病史显著相关。

这个研究的的重要意义在于,发现了:与全球一般人群相比,孤立性肌张力障碍患者的自杀行为发生率增加,但这未被认识到。应将自杀风险的筛查纳入肌张力障碍患者的临床评估中,以预防其自杀诱发的伤害和死亡。

原文出处:

Suicidal Ideations and Attempts in Patients with Isolated Dystonia; Alexis Worthley, Kristina Simonyan; Neurology Jan 2021, 10.1212/WNL.0000000000011596; DOI: 10.1212/WNL.0000000000011596

 
 
 
 

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    2021-03-01 yinhl1978
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    2021-02-02 jxrzshh
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    2021-02-02 gujh
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    2021-02-01 ms8000001758502453

    学习了

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    2021-02-01 飞翔的乌龟

    0

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