JACC:人类动脉粥样硬化斑块中的血管滋养管

2015-06-09 崔倩 译 MedSci原创

背景:以往的研究表明,血管滋养管(VV)与动脉粥样斑块的进展和脆弱性相关。    意义:本研究的目的是调查冠状动脉血管形成的结构和斑块特性之间的关系。    方法:该研究包括接受光学相干断层扫描来观察冠状动脉左前降支近端的53例患者。患者根据病变的特点分为5组:正常、纤维斑(FP)、纤维斑块(FA)、斑块破裂(PR)和纤维钙化斑块(FC)

背景:以往的研究表明,血管滋养管(VV)与动脉粥样斑块的进展和脆弱性相关。
    
意义:本研究的目的是调查冠状动脉血管形成的结构和斑块特性之间的关系。
    
方法:该研究包括接受光学相干断层扫描来观察冠状动脉左前降支近端的53例患者。患者根据病变的特点分为5组:正常、纤维斑(FP)、纤维斑块(FA)、斑块破裂(PR)和纤维钙化斑块(FC)。研究人员将具有代表性的信号差的管腔结构和位于外膜层剖面定义于VV,内斑块作为斑块新生血管。并对两种类型的纵向结构微血管(外部运行和内部运行)和一个特定类型的斑块新生血管(珊瑚树模式)进行了说明。所有的VV和斑块内新生血管进行分割然后用辛普森法定量。
    
结果:在这些组中,VV体积(正常:0.329[IQR:0.209到0.361]立方毫米,FP:0.433[IQR:0.297至0.706]立方毫米,FA:0.288[IQR:0.113到0.364]立方毫米,PR:0.160[IQR:0.141至0.193]立方毫米,FC:0.106[IQR:0.053至0.165]立方毫米;P=0.003)和斑块新生血管体积(正常:0.00[IQR:0.00至0.00]立方毫米,FP:0.00[IQR:0.00〜0.00]立方毫米,FA:0.028[IQR:0.019至0.041]立方毫米,PR:0.035[IQR:0.026至0.042]立方毫米,FC:0.010[IQR:0.005至0.014]立方毫米;P<0.001)有显著差异(表示为中位数[四分位距(IQR)])。观察到的内部运行的患病率(正常值:0.0%,FP:28.6%,FA:40.0%,PR:70.0%,和FC:40.0%,P=0.032)和珊瑚树模式(正常:0.0%,FP:7.1%,FA:40.0%,PR:80.0%,和FC:10.0%,P<0.01)有显著差异。VV体积与纤维斑块体积相关(r=0.71,P<0.01)。
    
结论:VV随纤维斑块体积和特别结构的斑块新生血管而增长,与斑块脆弱性相关。微血管成像可能成为易损斑块的一个新窗口。

原始出处:

Akira Taruya;Atsushi Tanaka;Tsuyoshi Nishiguchi;et al.Vasa Vasorum Restructuring in Human Atherosclerotic Plaque Vulnerability,JACC,2015.6.9

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    2015-06-24 hbwxf
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    2015-06-11 18619c0a62m

    新奇

    0

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    2015-06-10 medcardio

    微血管成像可能成为易损斑块的一个新窗口。

    0

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    2015-06-10 alicelee

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    2015-06-10 alicelee

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    2015-06-10 alicelee

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