JACC:右心室功能不全常共存心源性恶病质

2013-08-07 高晓方 译 cmt

捷克一项研究表明,右心室功能不全和心源性恶病质往往共存;二者具有附加不良影响,并可能存在相关机制。论文7月在线发表于《美国心脏病学会杂志》(J Am Coll Cardiol)。 此项研究共纳入408例晚期心衰患者,并对身体成分(皮肤壁厚度)、超声心动图和血液检测进行了前瞻性评估。对受试者进行以死亡、移植或循环辅助装置应用为定义的不良事件随访。 结果显示,伴右心室

捷克一项研究表明,右心室功能不全和心源性恶病质往往共存;二者具有附加不良影响,并可能存在相关机制。论文7月在线发表于《美国心脏病学会杂志》(J Am Coll Cardiol)。

此项研究共纳入408例晚期心衰患者,并对身体成分(皮肤壁厚度)、超声心动图和血液检测进行了前瞻性评估。对受试者进行以死亡、移植或循环辅助装置应用为定义的不良事件随访。

结果显示,伴右心室功能不全的受试者(51%)体质指数(BMI)较低,体脂指数较低,并且更有可能出现恶病质(19%)。右心室功能不全程度与既往体重减轻较多以及脂体重/瘦体重比较低具有相关性。中位随访541天期间共发生150起不良事件(37%)。在伴右心室功能不全和恶病质的受试者中事件风险较高。BMI增加与事件发生率较低相关,并且该保护效应由脂肪量较高而非去脂体重指数介导。

Vojtech Melenovsky; Martin Kotrc; Barry A. Borlaug; Tomas Marek; Jan Kovar; Ivan Malek; Josef Kautzner.Relationships between Right Ventricular Function, Body Composition and Prognosis in Advanced Heart Failure.J Am Coll Cardiol. 2013;():. doi:10.1016/j.jacc.2013.06.046

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    2014-01-02 hbwxf
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    2013-09-13 wincls
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    2013-08-09 mhm295