Dermatology:银屑病关节炎患者的皮肤病比单纯银屑病患者更严重?

2022-06-16 MedSci原创 MedSci原创

早期识别有银屑病关节炎(PsA)风险的患者对于促进早期诊断和改善临床结果至关重要。严重的皮肤银屑病被认为与PsA有关,但最近缺乏对证据的评估。

早期识别有银屑病关节炎(PsA)风险的患者对于促进早期诊断和改善临床结果至关重要。严重的皮肤银屑病被认为与PsA有关,但最近缺乏对证据的评估。近日,发表于Dermatology的一项系统综述讨论了银屑病皮肤严重程度与PsA的存在和发展的关系。

 

研究人员纳入了2014年发表的一篇综述中的文章,并通过进行额外的系统性搜索来确定2013年1月1日至2021年2月11日之间发表的研究,对这些文章进行补充。

结果,在2,000篇经过筛选的文章中,最终将29篇纳入分析,其中16篇是通过研究人员更新的搜索发现的。19项研究以“银屑病面积和严重程度指数(PASI)”报告银屑病严重程度,10项研究以“体表面积(BSA)”报告,2项研究以 "受影响部位的数量"报告。大多数研究显示,更广泛的皮肤病与PsA的存在有关。定量汇总分析结果显示,与没有PsA的银屑病患者相比,PsA患者的PASI更高(平均差异[Δ]1.59;95%置信区间[CI]0.29-2.89),BSA更高(Δ5.31;95%CI 1.78-8.83)。评估银屑病患者未来发展为PsA的风险-的前瞻性研究的结果并不确定。

综上所述,该研究结果表明,在银屑病患者中,PsA的存在与严重的皮肤受累有关,这突出了皮肤科和风湿科在临床护理中最佳合作的重要性。但是,目前没有足够的数据支持使用银屑病皮肤的严重程度来预测银屑病患者未来PsA的发展。研究存在几个局限性,无法探究潜在的混杂因素,包括银屑病的定位、PsA的家族史、肥胖、骨折创伤史和吸烟状况。

原始出处:

Juliëtte N Pouw, et al., Do Patients with Psoriatic Arthritis Have More Severe Skin Disease than Patients with Psoriasis Only? A Systematic Review and Meta-Analysis. Dermatology. 2022 May 12;1-12. doi: 10.1159/000524231.

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