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Stroke：微出血对急性缺血性卒中患者再通后结局的影响

2019-01-13 MedSci MedSci原创

multivariateAnalysisStrokeIntracranialhemorrhage
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微出血在急性缺血性卒中患者再通后对于大脑组织的影响目前还没有文献进行研究，因此本项研究分析了急性缺血性卒中患者脑微出血（CMBs）与临床结果之间的关系，特别是成功再通的患者亚组中的情况。

背景和目的
微出血在急性缺血性卒中患者再通后对于大脑组织的影响目前还没有文献进行研究，因此本项研究分析了急性缺血性卒中患者脑微出血（CMBs）与临床结果之间的关系，特别是成功再通的患者亚组中的情况。

方法
在本项前瞻性队列研究中，共有1532名接受静脉溶栓或机械血栓切除术的急性缺血性卒中患者参加了研究。根据入院时基于磁共振成像的CMB状态，使用3个月时的改良Rankin量表测量主要结果。再通被定义为功能独立，改良Rankin量表评分为0至2分。次要结果包括症状性颅内出血的发生。

结果
3个月时CMB的存在与血管再通结果之间没有统计学显着相关性（44.3％VS37.6％； P = 0.121）。在再通患者中，CMB阴性患者的有利结果显着高于CMB阳性组（57.0％VS36.0％； P <0.001）。在最终的多变量分析中，CMB的存在，特别是高CMB负荷（≥5）与3个月结果显着相关（OR= 0.57； 95％CI，0.33-0.97； P = 0.038）和症状性颅内出血（OR= 3.21； 95％CI，1.37-7.49； P= 0.007）。在亚组的分析中，CMB的存在和再通之间发现了统计学上显着的相互作用。

结论
本项研究结果表明，CMB的存在，特别是高负荷，是3个月临床结果差的独立预测因子，并且可能增加再通的急性缺血性卒中患者的症状性颅内出血风险。我们的研究结果表明，CMBs对大血管闭塞后血管再通的患者的影响比没有血管再通的患者更不利。

原始出处：

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    2019-05-09 liuxiaona

    #微出血#

    0

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    2019-03-04 zhouqu_8

    #缺血性#

    0

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    2019-10-21 wjywjy

    #缺血性卒中患者#

    0

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    2019-03-06 wangyang7969

    #卒中患者#

    0

  5. [GetPortalCommentsPageByObjectIdResponse(id=1674858, encodeId=bc1016e485828, content=<a href='/topic/show?id=60fb50501b3' target=_blank style='color:#2F92EE;'>#微出血#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=50501, encryptionId=60fb50501b3, topicName=微出血)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=5c7927121733, createdName=liuxiaona, createdTime=Thu May 09 20:57:00 CST 2019, time=2019-05-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1893143, encodeId=ec72189314336, content=<a href='/topic/show?id=c738e93521f' target=_blank style='color:#2F92EE;'>#缺血性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=18, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=79352, encryptionId=c738e93521f, topicName=缺血性)], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/aLGWoFXAyMbIu3qymFOyheQLjPSX3OUs5GmkyBlcCOwTPIeq3why9NGibxxUqYo6hcx8qZLHZFgNPnBK1yzWeOFpyg2OnWOt0/0, createdBy=fa4716, createdName=zhouqu_8, createdTime=Mon Mar 04 08:57:00 CST 2019, time=2019-03-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2010399, encodeId=b1a420103997e, content=<a href='/topic/show?id=9cf7e9360d2' target=_blank style='color:#2F92EE;'>#缺血性卒中患者#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=24, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=79360, encryptionId=9cf7e9360d2, topicName=缺血性卒中患者)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=1072181, createdName=wjywjy, createdTime=Mon Oct 21 13:57:00 CST 2019, time=2019-10-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1720275, encodeId=e5b01e2027571, content=<a href='/topic/show?id=915c3604e6b' target=_blank style='color:#2F92EE;'>#卒中患者#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=21, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=36047, encryptionId=915c3604e6b, topicName=卒中患者)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=940232842333, createdName=wangyang7969, createdTime=Wed Mar 06 21:57:00 CST 2019, time=2019-03-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1806305, encodeId=9a7d1806305c9, content=<a href='/topic/show?id=b649e9358fa' target=_blank style='color:#2F92EE;'>#缺血性卒#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=23, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=79358, encryptionId=b649e9358fa, topicName=缺血性卒)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=636e2500187, createdName=12498da4m32(暂无昵称), createdTime=Fri Nov 15 23:57:00 CST 2019, time=2019-11-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=358174, encodeId=c4e43581e496, content=感谢小编为我们准备了如此丰盛的精神大餐，同时也向作者致谢！认真学习了，点赞！, beContent=null, objectType=article, channel=null, level=null, likeNumber=41, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=eb131638261, createdName=lietome24, createdTime=Tue Jan 15 08:20:22 CST 2019, time=2019-01-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1026267, encodeId=83b3102626ebc, content=卒中虽然是临床上常见病，溶栓，取栓等血管内治疗也很成熟，但是仍然有很多未知问题有待认知！, beContent=null, objectType=article, channel=null, level=null, likeNumber=22, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=健健, createdTime=Sun Jan 13 16:57:00 CST 2019, time=2019-01-13, status=1, ipAttribution=)]
    2019-11-15 12498da4m32(暂无昵称)

    #缺血性卒#

    0

  6. [GetPortalCommentsPageByObjectIdResponse(id=1674858, encodeId=bc1016e485828, content=<a href='/topic/show?id=60fb50501b3' target=_blank style='color:#2F92EE;'>#微出血#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=50501, encryptionId=60fb50501b3, topicName=微出血)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=5c7927121733, createdName=liuxiaona, createdTime=Thu May 09 20:57:00 CST 2019, time=2019-05-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1893143, encodeId=ec72189314336, content=<a href='/topic/show?id=c738e93521f' target=_blank style='color:#2F92EE;'>#缺血性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=18, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=79352, encryptionId=c738e93521f, topicName=缺血性)], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/aLGWoFXAyMbIu3qymFOyheQLjPSX3OUs5GmkyBlcCOwTPIeq3why9NGibxxUqYo6hcx8qZLHZFgNPnBK1yzWeOFpyg2OnWOt0/0, createdBy=fa4716, createdName=zhouqu_8, createdTime=Mon Mar 04 08:57:00 CST 2019, time=2019-03-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2010399, encodeId=b1a420103997e, content=<a href='/topic/show?id=9cf7e9360d2' target=_blank style='color:#2F92EE;'>#缺血性卒中患者#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=24, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=79360, encryptionId=9cf7e9360d2, topicName=缺血性卒中患者)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=1072181, createdName=wjywjy, createdTime=Mon Oct 21 13:57:00 CST 2019, time=2019-10-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1720275, encodeId=e5b01e2027571, content=<a href='/topic/show?id=915c3604e6b' target=_blank style='color:#2F92EE;'>#卒中患者#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=21, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=36047, encryptionId=915c3604e6b, topicName=卒中患者)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=940232842333, createdName=wangyang7969, createdTime=Wed Mar 06 21:57:00 CST 2019, time=2019-03-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1806305, encodeId=9a7d1806305c9, content=<a href='/topic/show?id=b649e9358fa' target=_blank style='color:#2F92EE;'>#缺血性卒#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=23, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=79358, encryptionId=b649e9358fa, topicName=缺血性卒)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=636e2500187, createdName=12498da4m32(暂无昵称), createdTime=Fri Nov 15 23:57:00 CST 2019, time=2019-11-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=358174, encodeId=c4e43581e496, content=感谢小编为我们准备了如此丰盛的精神大餐，同时也向作者致谢！认真学习了，点赞！, beContent=null, objectType=article, channel=null, level=null, likeNumber=41, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=eb131638261, createdName=lietome24, createdTime=Tue Jan 15 08:20:22 CST 2019, time=2019-01-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1026267, encodeId=83b3102626ebc, content=卒中虽然是临床上常见病，溶栓，取栓等血管内治疗也很成熟，但是仍然有很多未知问题有待认知！, beContent=null, objectType=article, channel=null, level=null, likeNumber=22, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=健健, createdTime=Sun Jan 13 16:57:00 CST 2019, time=2019-01-13, status=1, ipAttribution=)]
    2019-01-15 lietome24

    感谢小编为我们准备了如此丰盛的精神大餐，同时也向作者致谢！认真学习了，点赞！

    0

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    2019-01-13 健健

    卒中虽然是临床上常见病，溶栓，取栓等血管内治疗也很成熟，但是仍然有很多未知问题有待认知！

    0