Diabetes Care:心率变异性(HRV)或为感觉运动性多发性神经病(DSP)生物标志物

2012-03-03 MedSci MedSci原创

  加拿大学者的一项研究表明,心率变异性(HRV)可能为临床糖尿病感觉运动性多发性神经病(DSP)的生物标志物,并且与早期和晚期神经病指标呈横向相关。论文于2012年2月22日在线发表于《糖尿病护理》(Diabetes Care)杂志。    此项研究共纳入89例糖尿病患者和60例健康志愿者。受试者在深呼吸期间接受RR间期变异(RRvar)评估以及临床和电生理评测。评估年龄标准化RRv

  加拿大学者的一项研究表明,心率变异性(HRV)可能为临床糖尿病感觉运动性多发性神经病(DSP)的生物标志物,并且与早期和晚期神经病指标呈横向相关。论文于2012年2月22日在线发表于《糖尿病护理》(Diabetes Care)杂志。

   此项研究共纳入89例糖尿病患者和60例健康志愿者。受试者在深呼吸期间接受RR间期变异(RRvar)评估以及临床和电生理评测。评估年龄标准化RRvar在临床DSP谱系内的分布,利用多变量回归确定与RRvar相关的变量,并对RRvar与经验证的神经病指标进行对比。

  结果显示,在糖尿病受试者中,年龄标准化RRvar与DSP严重度增加的顺序分类呈显著分段式负相关(P<0.0001)。与无DSP的糖尿病对照者相比,伴DSP糖尿病受试者的年龄标准化RRvar显著降低(P<0.01),但糖尿病受试者、对照受试者和健康志愿者在RRvar方面存在显著重叠。

  多变量分析显示,在健康志愿者和糖尿病受试者中高龄均与RRvar较低呈独立相关;在糖尿病受试者中糖化血红蛋白A1c和收缩压较高则与RRvar较低呈独立相关。RRvar与大、小纤维精神病的经验证指标显著相关。

  链接:

  Heart Rate Variability and Sensorimotor Polyneuropathy in Type 1 Diabetes

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createdName=hukaixun, createdTime=Thu Aug 02 17:49:00 CST 2012, time=2012-08-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1709201, encodeId=35691e092014d, content=<a href='/topic/show?id=dd2f43108e4' target=_blank style='color:#2F92EE;'>#多发性神经病#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=41, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=43108, encryptionId=dd2f43108e4, topicName=多发性神经病)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=849831619609, createdName=ms3892185887221420, createdTime=Wed Apr 25 18:49:00 CST 2012, time=2012-04-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1889522, encodeId=c05b188952288, content=<a href='/topic/show?id=760c430895a' target=_blank style='color:#2F92EE;'>#多发性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=43089, encryptionId=760c430895a, topicName=多发性)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=04d6114, createdName=jml2009, createdTime=Sat Jul 07 22:49:00 CST 2012, time=2012-07-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1636474, encodeId=7a1a16364e407, content=<a href='/topic/show?id=afda591646' target=_blank style='color:#2F92EE;'>#DIA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=37, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5916, encryptionId=afda591646, topicName=DIA)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=987022654425, createdName=ms9608593228839890, createdTime=Sun May 20 10:49:00 CST 2012, time=2012-05-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1759114, encodeId=cc971e59114e6, content=<a href='/topic/show?id=9bea33520d' target=_blank style='color:#2F92EE;'>#BET#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=26, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=3352, encryptionId=9bea33520d, topicName=BET)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=9a1a37427546, createdName=ms5439512287675881, createdTime=Tue Jan 15 05:49:00 CST 2013, time=2013-01-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1342245, encodeId=6b6c1342245cf, content=<a href='/topic/show?id=34cb381023e' target=_blank style='color:#2F92EE;'>#变异#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=38102, encryptionId=34cb381023e, topicName=变异)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=78c32500188, createdName=12498dabm77暂无昵称, createdTime=Mon Mar 05 01:49:00 CST 2012, time=2012-03-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1441555, encodeId=91d914415551c, content=<a href='/topic/show?id=ae0d511063d' target=_blank style='color:#2F92EE;'>#心率变异性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=51106, encryptionId=ae0d511063d, topicName=心率变异性)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=3b234868163, createdName=ms705947299214030, createdTime=Mon Mar 05 01:49:00 CST 2012, time=2012-03-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1491201, encodeId=62d0149120135, content=<a href='/topic/show?id=5316e4387aa' target=_blank style='color:#2F92EE;'>#神经病#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=26, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=74387, encryptionId=5316e4387aa, topicName=神经病)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=1ab48885684, createdName=axin012, createdTime=Mon Mar 05 01:49:00 CST 2012, time=2012-03-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1560492, encodeId=557d156049272, content=<a href='/topic/show?id=3c746936567' target=_blank style='color:#2F92EE;'>#生物标志#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=69365, encryptionId=3c746936567, topicName=生物标志)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=63db15173977, createdName=zhu_jun9842, createdTime=Mon Mar 05 01:49:00 CST 2012, time=2012-03-05, status=1, ipAttribution=)]
    2012-07-07 jml2009
  5. [GetPortalCommentsPageByObjectIdResponse(id=1900925, encodeId=096e19009251a, content=<a href='/topic/show?id=c097591ed5' target=_blank style='color:#2F92EE;'>#Diabetes#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=45, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5917, encryptionId=c097591ed5, topicName=Diabetes)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=0045169, createdName=木头人513, createdTime=Sun Oct 21 19:49:00 CST 2012, time=2012-10-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1840726, encodeId=1f8a1840e2674, content=<a href='/topic/show?id=18bf61953d3' target=_blank style='color:#2F92EE;'>#标志物#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=36, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=61953, encryptionId=18bf61953d3, topicName=标志物)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=6ab940, 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beContent=null, objectType=article, channel=null, level=null, likeNumber=26, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=3352, encryptionId=9bea33520d, topicName=BET)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=9a1a37427546, createdName=ms5439512287675881, createdTime=Tue Jan 15 05:49:00 CST 2013, time=2013-01-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1342245, encodeId=6b6c1342245cf, content=<a href='/topic/show?id=34cb381023e' target=_blank style='color:#2F92EE;'>#变异#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=38102, encryptionId=34cb381023e, topicName=变异)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=78c32500188, createdName=12498dabm77暂无昵称, createdTime=Mon Mar 05 01:49:00 CST 2012, time=2012-03-05, status=1, ipAttribution=), 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createdBy=1ab48885684, createdName=axin012, createdTime=Mon Mar 05 01:49:00 CST 2012, time=2012-03-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1560492, encodeId=557d156049272, content=<a href='/topic/show?id=3c746936567' target=_blank style='color:#2F92EE;'>#生物标志#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=69365, encryptionId=3c746936567, topicName=生物标志)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=63db15173977, createdName=zhu_jun9842, createdTime=Mon Mar 05 01:49:00 CST 2012, time=2012-03-05, status=1, ipAttribution=)]
  6. [GetPortalCommentsPageByObjectIdResponse(id=1900925, encodeId=096e19009251a, content=<a href='/topic/show?id=c097591ed5' target=_blank style='color:#2F92EE;'>#Diabetes#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=45, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5917, encryptionId=c097591ed5, topicName=Diabetes)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=0045169, createdName=木头人513, createdTime=Sun Oct 21 19:49:00 CST 2012, time=2012-10-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1840726, encodeId=1f8a1840e2674, content=<a href='/topic/show?id=18bf61953d3' target=_blank style='color:#2F92EE;'>#标志物#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=36, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=61953, encryptionId=18bf61953d3, topicName=标志物)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=6ab940, 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beContent=null, objectType=article, channel=null, level=null, likeNumber=26, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=3352, encryptionId=9bea33520d, topicName=BET)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=9a1a37427546, createdName=ms5439512287675881, createdTime=Tue Jan 15 05:49:00 CST 2013, time=2013-01-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1342245, encodeId=6b6c1342245cf, content=<a href='/topic/show?id=34cb381023e' target=_blank style='color:#2F92EE;'>#变异#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=38102, encryptionId=34cb381023e, topicName=变异)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=78c32500188, createdName=12498dabm77暂无昵称, createdTime=Mon Mar 05 01:49:00 CST 2012, time=2012-03-05, status=1, ipAttribution=), 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  7. [GetPortalCommentsPageByObjectIdResponse(id=1900925, encodeId=096e19009251a, content=<a href='/topic/show?id=c097591ed5' target=_blank style='color:#2F92EE;'>#Diabetes#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=45, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5917, encryptionId=c097591ed5, topicName=Diabetes)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=0045169, createdName=木头人513, createdTime=Sun Oct 21 19:49:00 CST 2012, time=2012-10-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1840726, encodeId=1f8a1840e2674, content=<a href='/topic/show?id=18bf61953d3' target=_blank style='color:#2F92EE;'>#标志物#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=36, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=61953, encryptionId=18bf61953d3, topicName=标志物)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=6ab940, 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createdBy=1ab48885684, createdName=axin012, createdTime=Mon Mar 05 01:49:00 CST 2012, time=2012-03-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1560492, encodeId=557d156049272, content=<a href='/topic/show?id=3c746936567' target=_blank style='color:#2F92EE;'>#生物标志#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=69365, encryptionId=3c746936567, topicName=生物标志)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=63db15173977, createdName=zhu_jun9842, createdTime=Mon Mar 05 01:49:00 CST 2012, time=2012-03-05, status=1, ipAttribution=)]
  8. [GetPortalCommentsPageByObjectIdResponse(id=1900925, encodeId=096e19009251a, content=<a href='/topic/show?id=c097591ed5' target=_blank style='color:#2F92EE;'>#Diabetes#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=45, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5917, encryptionId=c097591ed5, topicName=Diabetes)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=0045169, createdName=木头人513, createdTime=Sun Oct 21 19:49:00 CST 2012, time=2012-10-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1840726, encodeId=1f8a1840e2674, content=<a href='/topic/show?id=18bf61953d3' target=_blank style='color:#2F92EE;'>#标志物#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=36, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=61953, encryptionId=18bf61953d3, topicName=标志物)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=6ab940, createdName=hukaixun, createdTime=Thu Aug 02 17:49:00 CST 2012, time=2012-08-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1709201, encodeId=35691e092014d, content=<a href='/topic/show?id=dd2f43108e4' target=_blank style='color:#2F92EE;'>#多发性神经病#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=41, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=43108, encryptionId=dd2f43108e4, topicName=多发性神经病)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=849831619609, createdName=ms3892185887221420, createdTime=Wed Apr 25 18:49:00 CST 2012, time=2012-04-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1889522, encodeId=c05b188952288, content=<a href='/topic/show?id=760c430895a' target=_blank style='color:#2F92EE;'>#多发性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, 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beContent=null, objectType=article, channel=null, level=null, likeNumber=26, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=3352, encryptionId=9bea33520d, topicName=BET)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=9a1a37427546, createdName=ms5439512287675881, createdTime=Tue Jan 15 05:49:00 CST 2013, time=2013-01-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1342245, encodeId=6b6c1342245cf, content=<a href='/topic/show?id=34cb381023e' target=_blank style='color:#2F92EE;'>#变异#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=38102, encryptionId=34cb381023e, topicName=变异)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=78c32500188, createdName=12498dabm77暂无昵称, createdTime=Mon Mar 05 01:49:00 CST 2012, time=2012-03-05, status=1, ipAttribution=), 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  9. [GetPortalCommentsPageByObjectIdResponse(id=1900925, encodeId=096e19009251a, content=<a href='/topic/show?id=c097591ed5' target=_blank style='color:#2F92EE;'>#Diabetes#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=45, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5917, encryptionId=c097591ed5, topicName=Diabetes)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=0045169, createdName=木头人513, createdTime=Sun Oct 21 19:49:00 CST 2012, time=2012-10-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1840726, encodeId=1f8a1840e2674, content=<a href='/topic/show?id=18bf61953d3' target=_blank style='color:#2F92EE;'>#标志物#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=36, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=61953, encryptionId=18bf61953d3, topicName=标志物)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=6ab940, 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    2012-03-05 axin012
  10. 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