Int J Impot Res:阿魏草根提取物对阴茎勃起功能障碍作用研究

2019-04-29 AlexYang MedSci原创

阴茎勃起功能障碍(ED)是糖尿病的一种重要的并发症。最近,有研究人员确定了是否阿魏草(FE)根提取物在链脲霉素(STZ)诱导的糖尿病小鼠中能够影响ED。研究包括了75只成年雄性小鼠,并均分成5等分;对照组(C)、FE组(40mg/kg-d)、STZ诱导的糖尿病组(60?mg/kg)(DM)、糖尿病+阿魏草根组(DM+FE)和乙醇组(EtOH)。8周后,研究人员评估了体外和体内各种参数。研究发现,在

阴茎勃起功能障碍(ED)是糖尿病的一种重要的并发症。最近,有研究人员确定了是否阿魏草(FE)根提取物在链脲霉素(STZ)诱导的糖尿病小鼠中能够影响ED。

研究包括了75只成年雄性小鼠,并均分成5等分;对照组(C)、FE组(40mg/kg-d)、STZ诱导的糖尿病组(60mg/kg)(DM)、糖尿病+阿魏草根组(DM+FE)和乙醇组(EtOH)。8周后,研究人员评估了体外和体内各种参数。研究发现,在STZ诱导的糖尿病组中,乙酰胆碱诱导的内皮细胞依赖的舒张反应以及电场刺激引起的神经源性和硝基能性松弛反应均显著减少,而FE给药糖尿病小鼠则能够恢复减少的硝基能性和神经源性松弛反应。在糖尿病足,ICP/MAP (0.1375±0.02cm/H2O)、睾丸精子发生(53.73±0.81)和睾丸的重量均显著减少;然而,FE给药糖尿病小鼠能够恢复上述减少的值(分别为0.350±0.019cm/H2O, 75.07±0.35和416±24.11)。在DM组,血糖水平与C组比较显著增加(411.7±18.30)。然而,FE给药能够减少血糖水平(230.6±25.60mg/dL)。

最后,研究人员指出,FE能够恢复神经源性和内皮功能紊乱,并减少糖尿病小鼠中血糖的水平。

原始出处:

Nadire Eser, Hacer Sinem Buyuknacar, Ozge Ozturk Cimentepe et al. The effect of Ferula elaeochytris root extract on erectile dysfunction in streptozotocin-induced diabetic rat. Int J Impot Res. 12 April 2019.

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    2019-12-07 habb
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    2019-05-01 dingxiaobo
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    2019-05-01 风铃826
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    2019-04-29 AlexYang

    中草药很有价值!

    0