有些防晒霜会杀精,科学家发现男性不育的潜在原因

2016-04-07 生物谷 梅斯医学

一项新研究发现,常用于防晒霜中的抗紫外线的物质会干扰精子细胞的功能,模仿女性激素黄体酮。这项丹麦的研究结果将于本周五在波士顿召开的第98届内分泌学会会议上公布。 这项研究的资深研究员、哥本哈根大学教授Niels Skakkebaek说,这些结果可能引起公众关注,并能部分解释,不明原因的不孕为何如此普遍。尽管加入这些抗紫外线的物质的目的是减少进入皮肤的紫外线量,但这些物质也会通过皮肤迅速被

一项新研究发现,常用于防晒霜中的抗紫外线的物质会干扰精子细胞的功能,模仿女性激素黄体酮。这项丹麦的研究结果将于本周五在波士顿召开的第98届内分泌学会会议上公布。

这项研究的资深研究员、哥本哈根大学教授Niels Skakkebaek说,这些结果可能引起公众关注,并能部分解释,不明原因的不孕为何如此普遍。尽管加入这些抗紫外线的物质的目的是减少进入皮肤的紫外线量,但这些物质也会通过皮肤迅速被人体吸收。据报导,抗紫外线的化学物质在美国、丹麦以及其他国家的血液样本和95%的尿液样本都可以检测到。

Skakkebaek和同事们用多个健康捐献者的新鲜精液样品测试了美国和多个欧洲国家使用的29种抗紫外线物质。受试条件的缓冲液模仿了女性输卵管中的环境。

具体来说,实验评估了钙信号(通过钙离子浓度变化向细胞内传递信号)。精子细胞中钙离子的运动对精子功能起到非常重要的作用。CatSper是精子细胞使用的钙离子通道,对男性生育功能至关重要。这个离子通道是精子感知强效激素引诱剂--孕激素的主要受体。孕激素结合到CatSper受体中会导致大量钙离子涌入精子细胞,控制受精所需的多种精子功能。

研究人员发现,检测的29种抗紫外线物质中有13种能诱导精子出现钙离子涌入现象,影响了正常精子功能。而这13种中有9种通过直接激活CatSper通道,模拟孕激素效果。Skakkebaek呼吁开展临床研究,以确认是否抗紫外线的化学物质是否影响人类的生育能力,监管机构应在批准产品上市之前检测其是否影响生育。

另外,这13种干扰精子细胞功能物质中的8种在美国是批准使用的。它们是亚佛苯酮、原膜散酯、拉地酯、水杨酸辛酯、桂皮酸盐、奥克立林、氧苯酮和二甲基氨基苯甲酸。这些物质是防晒霜或防晒个人护理产品中的活性成分,如化妆品、护肤品及唇膏等。

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    2016-04-14 李继凯

    文章不错

    0

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    2016-04-14 李继凯

    值得关注

    0

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  5. [GetPortalCommentsPageByObjectIdResponse(id=1802314, encodeId=5c881802314c5, content=<a href='/topic/show?id=acfae485578' target=_blank style='color:#2F92EE;'>#科学家发现#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=26, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=74855, encryptionId=acfae485578, topicName=科学家发现)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e572480, createdName=旅苦化文_208, createdTime=Mon Jun 13 11:49:00 CST 2016, time=2016-06-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=78262, encodeId=581ce826205, content=文章不错, beContent=null, objectType=article, channel=null, level=null, likeNumber=66, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=240a1683959, createdName=李继凯, createdTime=Thu Apr 14 18:51:00 CST 2016, time=2016-04-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=78263, encodeId=a7abe826365, content=值得关注, beContent=null, objectType=article, channel=null, level=null, likeNumber=79, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=240a1683959, createdName=李继凯, createdTime=Thu Apr 14 18:51:00 CST 2016, time=2016-04-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1630685, encodeId=9c4616306852b, content=<a href='/topic/show?id=447c9e40871' target=_blank style='color:#2F92EE;'>#防晒霜#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=36, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=97408, encryptionId=447c9e40871, topicName=防晒霜)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=3dbd21562707, createdName=闆锋旦, createdTime=Sat Apr 09 07:49:00 CST 2016, time=2016-04-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=76443, encodeId=910de644364, content=化学品, beContent=null, objectType=article, channel=null, level=null, likeNumber=166, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTK29w9r0upRgxUXHNhe7bd3VxHnhBSpibMbKOjtX92zXr78SkuZfUNuADrjHiaw6uibZaEYjh9cJLzew/132, createdBy=261e1682638, createdName=1de3b290m83(暂无匿称), createdTime=Fri Apr 08 19:48:00 CST 2016, time=2016-04-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=76364, encodeId=a772e6364ac, content=这方面没留意到。, beContent=null, objectType=article, channel=null, level=null, likeNumber=169, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160313/IMG56E50DEC424F44672.jpg, createdBy=ce5b1699635, createdName=Lisa971, createdTime=Fri Apr 08 12:31:00 CST 2016, time=2016-04-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=76353, encodeId=ebbde6353be, content=天天呆在手术室没机会晒啊, beContent=null, objectType=article, channel=null, level=null, likeNumber=177, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/PiajxSqBRaEJJAFMgSjibMicGVUgkmDBw4svXiccQxZicwjRHNxGPTghAmITxP12Rcmm0yFKfwGwUaiaUwpPUUUTOd2g/0, createdBy=fcd21609070, createdName=hekzn, createdTime=Fri Apr 08 09:07:00 CST 2016, time=2016-04-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=76326, encodeId=8e2ae632643, content=这个真是不知道, beContent=null, objectType=article, channel=null, level=null, likeNumber=98, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=823a1692210, createdName=johnstone, createdTime=Thu Apr 07 22:49:00 CST 2016, time=2016-04-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=76310, encodeId=7223e63103e, content=生活中真是防不胜防, beContent=null, objectType=article, channel=null, level=null, likeNumber=75, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e4371683642, createdName=文医生, createdTime=Thu Apr 07 18:57:00 CST 2016, time=2016-04-07, status=1, ipAttribution=)]
    2016-04-08 1de3b290m83(暂无匿称)

    化学品

    0

  6. [GetPortalCommentsPageByObjectIdResponse(id=1802314, encodeId=5c881802314c5, content=<a href='/topic/show?id=acfae485578' target=_blank style='color:#2F92EE;'>#科学家发现#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=26, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=74855, encryptionId=acfae485578, topicName=科学家发现)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e572480, createdName=旅苦化文_208, createdTime=Mon Jun 13 11:49:00 CST 2016, time=2016-06-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=78262, encodeId=581ce826205, content=文章不错, beContent=null, objectType=article, channel=null, level=null, likeNumber=66, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=240a1683959, createdName=李继凯, createdTime=Thu Apr 14 18:51:00 CST 2016, time=2016-04-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=78263, encodeId=a7abe826365, content=值得关注, beContent=null, objectType=article, channel=null, level=null, likeNumber=79, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=240a1683959, createdName=李继凯, createdTime=Thu Apr 14 18:51:00 CST 2016, time=2016-04-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1630685, encodeId=9c4616306852b, content=<a href='/topic/show?id=447c9e40871' target=_blank style='color:#2F92EE;'>#防晒霜#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=36, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=97408, encryptionId=447c9e40871, topicName=防晒霜)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=3dbd21562707, createdName=闆锋旦, createdTime=Sat Apr 09 07:49:00 CST 2016, time=2016-04-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=76443, encodeId=910de644364, content=化学品, beContent=null, objectType=article, channel=null, level=null, likeNumber=166, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTK29w9r0upRgxUXHNhe7bd3VxHnhBSpibMbKOjtX92zXr78SkuZfUNuADrjHiaw6uibZaEYjh9cJLzew/132, createdBy=261e1682638, createdName=1de3b290m83(暂无匿称), createdTime=Fri Apr 08 19:48:00 CST 2016, time=2016-04-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=76364, encodeId=a772e6364ac, content=这方面没留意到。, beContent=null, objectType=article, channel=null, level=null, likeNumber=169, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160313/IMG56E50DEC424F44672.jpg, createdBy=ce5b1699635, createdName=Lisa971, createdTime=Fri Apr 08 12:31:00 CST 2016, time=2016-04-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=76353, encodeId=ebbde6353be, content=天天呆在手术室没机会晒啊, beContent=null, objectType=article, channel=null, level=null, likeNumber=177, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/PiajxSqBRaEJJAFMgSjibMicGVUgkmDBw4svXiccQxZicwjRHNxGPTghAmITxP12Rcmm0yFKfwGwUaiaUwpPUUUTOd2g/0, createdBy=fcd21609070, createdName=hekzn, createdTime=Fri Apr 08 09:07:00 CST 2016, time=2016-04-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=76326, encodeId=8e2ae632643, content=这个真是不知道, beContent=null, objectType=article, channel=null, level=null, likeNumber=98, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=823a1692210, createdName=johnstone, createdTime=Thu Apr 07 22:49:00 CST 2016, time=2016-04-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=76310, encodeId=7223e63103e, content=生活中真是防不胜防, beContent=null, objectType=article, channel=null, level=null, likeNumber=75, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e4371683642, createdName=文医生, createdTime=Thu Apr 07 18:57:00 CST 2016, time=2016-04-07, status=1, ipAttribution=)]
    2016-04-08 Lisa971

    这方面没留意到。

    0

  7. [GetPortalCommentsPageByObjectIdResponse(id=1802314, encodeId=5c881802314c5, content=<a href='/topic/show?id=acfae485578' target=_blank style='color:#2F92EE;'>#科学家发现#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=26, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=74855, encryptionId=acfae485578, topicName=科学家发现)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e572480, createdName=旅苦化文_208, createdTime=Mon Jun 13 11:49:00 CST 2016, time=2016-06-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=78262, encodeId=581ce826205, content=文章不错, beContent=null, objectType=article, channel=null, level=null, likeNumber=66, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=240a1683959, createdName=李继凯, createdTime=Thu Apr 14 18:51:00 CST 2016, time=2016-04-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=78263, encodeId=a7abe826365, content=值得关注, beContent=null, objectType=article, channel=null, level=null, likeNumber=79, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=240a1683959, createdName=李继凯, createdTime=Thu Apr 14 18:51:00 CST 2016, time=2016-04-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1630685, encodeId=9c4616306852b, content=<a href='/topic/show?id=447c9e40871' target=_blank style='color:#2F92EE;'>#防晒霜#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=36, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=97408, encryptionId=447c9e40871, topicName=防晒霜)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=3dbd21562707, createdName=闆锋旦, createdTime=Sat Apr 09 07:49:00 CST 2016, time=2016-04-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=76443, encodeId=910de644364, content=化学品, beContent=null, objectType=article, channel=null, level=null, likeNumber=166, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTK29w9r0upRgxUXHNhe7bd3VxHnhBSpibMbKOjtX92zXr78SkuZfUNuADrjHiaw6uibZaEYjh9cJLzew/132, createdBy=261e1682638, createdName=1de3b290m83(暂无匿称), createdTime=Fri Apr 08 19:48:00 CST 2016, time=2016-04-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=76364, encodeId=a772e6364ac, content=这方面没留意到。, beContent=null, objectType=article, channel=null, level=null, likeNumber=169, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160313/IMG56E50DEC424F44672.jpg, createdBy=ce5b1699635, createdName=Lisa971, createdTime=Fri Apr 08 12:31:00 CST 2016, time=2016-04-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=76353, encodeId=ebbde6353be, content=天天呆在手术室没机会晒啊, beContent=null, objectType=article, channel=null, level=null, likeNumber=177, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/PiajxSqBRaEJJAFMgSjibMicGVUgkmDBw4svXiccQxZicwjRHNxGPTghAmITxP12Rcmm0yFKfwGwUaiaUwpPUUUTOd2g/0, createdBy=fcd21609070, createdName=hekzn, createdTime=Fri Apr 08 09:07:00 CST 2016, time=2016-04-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=76326, encodeId=8e2ae632643, content=这个真是不知道, beContent=null, objectType=article, channel=null, level=null, likeNumber=98, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=823a1692210, createdName=johnstone, createdTime=Thu Apr 07 22:49:00 CST 2016, time=2016-04-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=76310, encodeId=7223e63103e, content=生活中真是防不胜防, beContent=null, objectType=article, channel=null, level=null, likeNumber=75, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e4371683642, createdName=文医生, createdTime=Thu Apr 07 18:57:00 CST 2016, time=2016-04-07, status=1, ipAttribution=)]
    2016-04-08 hekzn

    天天呆在手术室没机会晒啊

    0

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    2016-04-07 johnstone

    这个真是不知道

    0

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    2016-04-07 文医生

    生活中真是防不胜防

    0

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