Gastroenterology:空腹血糖升高及持续时间或成为胰管腺癌的早期诊断依据

2018-05-07 zhangfan MedSci原创

研究发现,空腹血糖升高和持续时间与胰管腺癌肿瘤大小及恶性程度相关,这一研究结果为胰管腺癌的早期诊断提供了依据

胰管腺癌(PDACS)的早期诊断对延长患者生存期十分关键,绝大多数PDAC患者确诊前存在高血糖与糖尿病症状。近日研究人员考察了早期侵袭性PDACS与高血糖及持续时间的相关性。

研究人员收集2000-15年间梅奥诊所肿瘤患者相关资料,收集PDAC患者确诊前60个月(n=219,队列A)、确诊PDAC患者(n=526、队列B)以及经手术后PDAC患者(n=103,队列C)的空腹血糖数(FBG)并与无肿瘤人群进行比较。研究的主要终点是空腹血糖与PDAC之间的相关性。

队列A中,患者确诊前36个月血糖水平与常人无显著差异,在确诊前36-30个月,所有患者血糖出现升高迹象,血糖持续升高直至患者确诊。在队列B中,肿瘤体积1.0cc以下人群,血糖与常人无异;血糖异常人群肿瘤至少为1.1-2.0cc;血糖升高水平与肿瘤体积相关,与肿瘤恶性程度相关:体积为5.8cc的中高分化肿瘤造成的血糖升高与体积在1.5cc的低分化肿瘤相当。在队列C中,肿瘤体积大、中小的PDAC患者其确诊前高血糖持续时间分别为36-24个月、24-12个月以及12-0个月,手术可缓解高血糖症状,其效果与肿瘤位置无关。

研究发现,空腹血糖升高和持续时间与胰管腺癌肿瘤大小及恶性程度相关,这一研究结果为胰管腺癌的早期诊断提供了依据。

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    2019-02-10 许安
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createdBy=f8412001184, createdName=惠映实验室, createdTime=Mon May 07 19:22:32 CST 2018, time=2018-05-07, status=1, ipAttribution=)]
    2018-05-09 zhwj
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topicName=AST)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=8b9831894722, createdName=ms24272190615788285182, createdTime=Mon Aug 13 04:26:00 CST 2018, time=2018-08-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1304973, encodeId=e80c13049e3e9, content=<a href='/topic/show?id=1970e539018' target=_blank style='color:#2F92EE;'>#空腹血糖#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=61, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=75390, encryptionId=1970e539018, topicName=空腹血糖)], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160723/IMG57937A3BB59F33185.jpg, createdBy=7642322, createdName=手留余香, createdTime=Wed May 09 05:26:00 CST 2018, time=2018-05-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1382685, encodeId=1362138268566, content=<a href='/topic/show?id=1f4e5946422' target=_blank 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createdBy=f8412001184, createdName=惠映实验室, createdTime=Mon May 07 19:22:32 CST 2018, time=2018-05-07, status=1, ipAttribution=)]
  9. 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createdBy=f8412001184, createdName=惠映实验室, createdTime=Mon May 07 19:22:32 CST 2018, time=2018-05-07, status=1, ipAttribution=)]
    2018-05-07 惠映实验室

    学习了.谢谢分享.

    0