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NEJM：GPIHBP1自身抗体引起高甘油三酯血症

2017-04-06 MedSci MedSci原创

GPIHBP1抗体高血脂
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GPIHBP1抗体阻断GPIHBP1结合和运输的脂蛋白脂肪酶的能力，从而干扰脂蛋白脂肪酶介导的甘油三酯的水解导致严重的高甘油三酯血症

GPIHBP1(糖基磷脂酰肌醇高密度脂蛋白结合蛋白1)是一种在毛细血管内皮细胞上表达的蛋白质，与脂蛋白脂酶结合并将其转运至毛细管腔的作用部位。GPIHBP1缺乏可以阻止脂蛋白脂酶到达毛细血管腔，GPIHBP1缺乏的病人临床表现为血浆脂蛋白脂肪酶水平低，血管内甘油三酯水解受阻导致严重的高甘油三酯血症(乳糜血)。

在一项最新研究中，研究人员采用免疫分析，Western blot分析和免疫细胞化学研究的方法，从高甘油三酯血症血液中提取了GPIHBP1自身抗体并测试了GPIHBP1抗体阻断脂蛋白脂肪酶结合GPIHBP1能力。

研究在6例乳糜血患者体内发现GPIHBP1抗体并发现这些抗体阻断脂蛋白脂肪酶GPIHBP1结合。与GPIHBP1缺失患者相同， GPIHBP1自身抗体患者其血浆脂蛋白脂肪酶水平低。6例乳糜血患者中有3人是系统性红斑狼疮患者；其中1名含GPIHBP1抗体的产妇生了1名含GPIHBP1抗体的婴儿，该婴儿有严重但短暂的乳糜微粒血症；2名含GPIHBP1抗体的乳糜血患者对免疫抑制剂治疗有应答。

通过对这6名乳糜血患者的研究表明，GPIHBP1抗体阻断GPIHBP1结合和运输的脂蛋白脂肪酶的能力，从而干扰脂蛋白脂肪酶介导的甘油三酯的水解导致严重的高甘油三酯血症。

原文出处：

Anne P. Beigneux et al. Autoantibodies against GPIHBP1 as a Cause of Hypertriglyceridemia N Engl J Med. April 5 2017

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    2017-06-08 flyingeagle85

    #高甘油三酯#

    0

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    2017-09-01 日月

    #GPIHBP1#

    0

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    2017-04-29 zmjlilei

    感谢分享一下

    0

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    2017-04-28 zmjlilei

    感谢分享一下

    0

  5. [GetPortalCommentsPageByObjectIdResponse(id=1654710, encodeId=edf21654e1076, content=<a href='/topic/show?id=edc610251468' target=_blank style='color:#2F92EE;'>#高甘油三酯#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=40, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=102514, encryptionId=edc610251468, topicName=高甘油三酯)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f5a424532179, createdName=flyingeagle85, createdTime=Thu Jun 08 23:23:00 CST 2017, time=2017-06-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2088942, encodeId=24fc20889427c, content=<a href='/topic/show?id=cbe6820410' target=_blank style='color:#2F92EE;'>#GPIHBP1#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=8204, encryptionId=cbe6820410, topicName=GPIHBP1)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4a4d285, createdName=日月, createdTime=Fri Sep 01 05:23:00 CST 2017, time=2017-09-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=191706, encodeId=241d191e06d1, content=感谢分享一下, beContent=null, objectType=article, channel=null, level=null, likeNumber=72, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=1a161743757, createdName=zmjlilei, createdTime=Sat Apr 29 07:12:44 CST 2017, time=2017-04-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=191390, encodeId=8f7e1913901c, content=感谢分享一下, beContent=null, objectType=article, channel=null, level=null, likeNumber=66, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=1a161743757, createdName=zmjlilei, createdTime=Fri Apr 28 08:47:16 CST 2017, time=2017-04-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=191102, encodeId=c06f191102f5, content=感谢分享一下, beContent=null, objectType=article, channel=null, level=null, likeNumber=68, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=1a161743757, createdName=zmjlilei, createdTime=Thu Apr 27 14:49:47 CST 2017, time=2017-04-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=190731, encodeId=6e06190e31bf, content=感谢分享一下, beContent=null, objectType=article, channel=null, level=null, likeNumber=62, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=1a161743757, createdName=zmjlilei, createdTime=Wed Apr 26 10:13:40 CST 2017, time=2017-04-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=190139, encodeId=5a401901392b, content=感谢分享一下, beContent=null, objectType=article, channel=null, level=null, likeNumber=57, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=1a161743757, createdName=zmjlilei, createdTime=Mon Apr 24 11:49:54 CST 2017, time=2017-04-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=189891, encodeId=5dbf189891a5, content=感谢分享一下, beContent=null, objectType=article, channel=null, level=null, likeNumber=21, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=1a161743757, createdName=zmjlilei, createdTime=Sun Apr 23 13:02:06 CST 2017, time=2017-04-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=189262, encodeId=14771892625b, content=感谢分享一下, beContent=null, objectType=article, channel=null, level=null, likeNumber=18, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=1a161743757, createdName=zmjlilei, createdTime=Fri Apr 21 07:46:28 CST 2017, time=2017-04-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=189010, encodeId=567b189010c8, content=感谢分享一下, beContent=null, objectType=article, channel=null, level=null, likeNumber=21, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=1a161743757, createdName=zmjlilei, createdTime=Thu Apr 20 08:29:35 CST 2017, time=2017-04-20, status=1, ipAttribution=)]
    2017-04-27 zmjlilei

    感谢分享一下

    0

  6. [GetPortalCommentsPageByObjectIdResponse(id=1654710, encodeId=edf21654e1076, content=<a href='/topic/show?id=edc610251468' target=_blank style='color:#2F92EE;'>#高甘油三酯#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=40, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=102514, encryptionId=edc610251468, topicName=高甘油三酯)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f5a424532179, createdName=flyingeagle85, createdTime=Thu Jun 08 23:23:00 CST 2017, time=2017-06-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2088942, encodeId=24fc20889427c, content=<a href='/topic/show?id=cbe6820410' target=_blank style='color:#2F92EE;'>#GPIHBP1#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=8204, encryptionId=cbe6820410, topicName=GPIHBP1)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4a4d285, createdName=日月, createdTime=Fri Sep 01 05:23:00 CST 2017, time=2017-09-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=191706, encodeId=241d191e06d1, content=感谢分享一下, beContent=null, objectType=article, channel=null, level=null, likeNumber=72, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=1a161743757, createdName=zmjlilei, createdTime=Sat Apr 29 07:12:44 CST 2017, time=2017-04-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=191390, encodeId=8f7e1913901c, content=感谢分享一下, beContent=null, objectType=article, channel=null, level=null, likeNumber=66, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=1a161743757, createdName=zmjlilei, createdTime=Fri Apr 28 08:47:16 CST 2017, time=2017-04-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=191102, encodeId=c06f191102f5, content=感谢分享一下, beContent=null, objectType=article, channel=null, level=null, likeNumber=68, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=1a161743757, createdName=zmjlilei, createdTime=Thu Apr 27 14:49:47 CST 2017, time=2017-04-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=190731, encodeId=6e06190e31bf, content=感谢分享一下, beContent=null, objectType=article, channel=null, level=null, likeNumber=62, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=1a161743757, createdName=zmjlilei, createdTime=Wed Apr 26 10:13:40 CST 2017, time=2017-04-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=190139, encodeId=5a401901392b, content=感谢分享一下, beContent=null, objectType=article, channel=null, level=null, likeNumber=57, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=1a161743757, createdName=zmjlilei, createdTime=Mon Apr 24 11:49:54 CST 2017, time=2017-04-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=189891, encodeId=5dbf189891a5, content=感谢分享一下, beContent=null, objectType=article, channel=null, level=null, likeNumber=21, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=1a161743757, createdName=zmjlilei, createdTime=Sun Apr 23 13:02:06 CST 2017, time=2017-04-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=189262, encodeId=14771892625b, content=感谢分享一下, beContent=null, objectType=article, channel=null, level=null, likeNumber=18, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=1a161743757, createdName=zmjlilei, createdTime=Fri Apr 21 07:46:28 CST 2017, time=2017-04-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=189010, encodeId=567b189010c8, content=感谢分享一下, beContent=null, objectType=article, channel=null, level=null, likeNumber=21, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=1a161743757, createdName=zmjlilei, createdTime=Thu Apr 20 08:29:35 CST 2017, time=2017-04-20, status=1, ipAttribution=)]
    2017-04-26 zmjlilei

    感谢分享一下

    0

  7. [GetPortalCommentsPageByObjectIdResponse(id=1654710, encodeId=edf21654e1076, content=<a href='/topic/show?id=edc610251468' target=_blank style='color:#2F92EE;'>#高甘油三酯#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=40, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=102514, encryptionId=edc610251468, topicName=高甘油三酯)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f5a424532179, createdName=flyingeagle85, createdTime=Thu Jun 08 23:23:00 CST 2017, time=2017-06-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2088942, encodeId=24fc20889427c, content=<a href='/topic/show?id=cbe6820410' target=_blank style='color:#2F92EE;'>#GPIHBP1#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=8204, encryptionId=cbe6820410, topicName=GPIHBP1)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4a4d285, createdName=日月, createdTime=Fri Sep 01 05:23:00 CST 2017, time=2017-09-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=191706, encodeId=241d191e06d1, content=感谢分享一下, beContent=null, objectType=article, channel=null, level=null, likeNumber=72, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=1a161743757, createdName=zmjlilei, createdTime=Sat Apr 29 07:12:44 CST 2017, time=2017-04-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=191390, encodeId=8f7e1913901c, content=感谢分享一下, beContent=null, objectType=article, channel=null, level=null, likeNumber=66, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=1a161743757, createdName=zmjlilei, createdTime=Fri Apr 28 08:47:16 CST 2017, time=2017-04-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=191102, encodeId=c06f191102f5, content=感谢分享一下, beContent=null, objectType=article, channel=null, level=null, likeNumber=68, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=1a161743757, createdName=zmjlilei, createdTime=Thu Apr 27 14:49:47 CST 2017, time=2017-04-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=190731, encodeId=6e06190e31bf, content=感谢分享一下, beContent=null, objectType=article, channel=null, level=null, likeNumber=62, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=1a161743757, createdName=zmjlilei, createdTime=Wed Apr 26 10:13:40 CST 2017, time=2017-04-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=190139, encodeId=5a401901392b, content=感谢分享一下, beContent=null, objectType=article, channel=null, level=null, likeNumber=57, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=1a161743757, createdName=zmjlilei, createdTime=Mon Apr 24 11:49:54 CST 2017, time=2017-04-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=189891, encodeId=5dbf189891a5, content=感谢分享一下, beContent=null, objectType=article, channel=null, level=null, likeNumber=21, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=1a161743757, createdName=zmjlilei, createdTime=Sun Apr 23 13:02:06 CST 2017, time=2017-04-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=189262, encodeId=14771892625b, content=感谢分享一下, beContent=null, objectType=article, channel=null, level=null, likeNumber=18, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=1a161743757, createdName=zmjlilei, createdTime=Fri Apr 21 07:46:28 CST 2017, time=2017-04-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=189010, encodeId=567b189010c8, content=感谢分享一下, beContent=null, objectType=article, channel=null, level=null, likeNumber=21, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=1a161743757, createdName=zmjlilei, createdTime=Thu Apr 20 08:29:35 CST 2017, time=2017-04-20, status=1, ipAttribution=)]
    2017-04-24 zmjlilei

    感谢分享一下

    0

  8. [GetPortalCommentsPageByObjectIdResponse(id=1654710, encodeId=edf21654e1076, content=<a href='/topic/show?id=edc610251468' target=_blank style='color:#2F92EE;'>#高甘油三酯#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=40, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=102514, encryptionId=edc610251468, topicName=高甘油三酯)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f5a424532179, createdName=flyingeagle85, createdTime=Thu Jun 08 23:23:00 CST 2017, time=2017-06-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2088942, encodeId=24fc20889427c, content=<a href='/topic/show?id=cbe6820410' target=_blank style='color:#2F92EE;'>#GPIHBP1#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=8204, encryptionId=cbe6820410, topicName=GPIHBP1)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4a4d285, createdName=日月, createdTime=Fri Sep 01 05:23:00 CST 2017, time=2017-09-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=191706, encodeId=241d191e06d1, content=感谢分享一下, beContent=null, objectType=article, channel=null, level=null, likeNumber=72, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=1a161743757, createdName=zmjlilei, createdTime=Sat Apr 29 07:12:44 CST 2017, time=2017-04-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=191390, encodeId=8f7e1913901c, content=感谢分享一下, beContent=null, objectType=article, channel=null, level=null, likeNumber=66, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=1a161743757, createdName=zmjlilei, createdTime=Fri Apr 28 08:47:16 CST 2017, time=2017-04-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=191102, encodeId=c06f191102f5, content=感谢分享一下, beContent=null, objectType=article, channel=null, level=null, likeNumber=68, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=1a161743757, createdName=zmjlilei, createdTime=Thu Apr 27 14:49:47 CST 2017, time=2017-04-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=190731, encodeId=6e06190e31bf, content=感谢分享一下, beContent=null, objectType=article, channel=null, level=null, likeNumber=62, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=1a161743757, createdName=zmjlilei, createdTime=Wed Apr 26 10:13:40 CST 2017, time=2017-04-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=190139, encodeId=5a401901392b, content=感谢分享一下, beContent=null, objectType=article, channel=null, level=null, likeNumber=57, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=1a161743757, createdName=zmjlilei, createdTime=Mon Apr 24 11:49:54 CST 2017, time=2017-04-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=189891, encodeId=5dbf189891a5, content=感谢分享一下, beContent=null, objectType=article, channel=null, level=null, likeNumber=21, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=1a161743757, createdName=zmjlilei, createdTime=Sun Apr 23 13:02:06 CST 2017, time=2017-04-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=189262, encodeId=14771892625b, content=感谢分享一下, beContent=null, objectType=article, channel=null, level=null, likeNumber=18, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=1a161743757, createdName=zmjlilei, createdTime=Fri Apr 21 07:46:28 CST 2017, time=2017-04-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=189010, encodeId=567b189010c8, content=感谢分享一下, beContent=null, objectType=article, channel=null, level=null, likeNumber=21, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=1a161743757, createdName=zmjlilei, createdTime=Thu Apr 20 08:29:35 CST 2017, time=2017-04-20, status=1, ipAttribution=)]
    2017-04-23 zmjlilei

    感谢分享一下

    0

  9. [GetPortalCommentsPageByObjectIdResponse(id=1654710, encodeId=edf21654e1076, content=<a href='/topic/show?id=edc610251468' target=_blank style='color:#2F92EE;'>#高甘油三酯#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=40, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=102514, encryptionId=edc610251468, topicName=高甘油三酯)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f5a424532179, createdName=flyingeagle85, createdTime=Thu Jun 08 23:23:00 CST 2017, time=2017-06-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2088942, encodeId=24fc20889427c, content=<a href='/topic/show?id=cbe6820410' target=_blank style='color:#2F92EE;'>#GPIHBP1#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=8204, encryptionId=cbe6820410, topicName=GPIHBP1)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4a4d285, createdName=日月, createdTime=Fri Sep 01 05:23:00 CST 2017, time=2017-09-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=191706, encodeId=241d191e06d1, content=感谢分享一下, beContent=null, objectType=article, channel=null, level=null, likeNumber=72, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=1a161743757, createdName=zmjlilei, createdTime=Sat Apr 29 07:12:44 CST 2017, time=2017-04-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=191390, encodeId=8f7e1913901c, content=感谢分享一下, beContent=null, objectType=article, channel=null, level=null, likeNumber=66, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=1a161743757, createdName=zmjlilei, createdTime=Fri Apr 28 08:47:16 CST 2017, time=2017-04-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=191102, encodeId=c06f191102f5, content=感谢分享一下, beContent=null, objectType=article, channel=null, level=null, likeNumber=68, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=1a161743757, createdName=zmjlilei, createdTime=Thu Apr 27 14:49:47 CST 2017, time=2017-04-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=190731, encodeId=6e06190e31bf, content=感谢分享一下, beContent=null, objectType=article, channel=null, level=null, likeNumber=62, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=1a161743757, createdName=zmjlilei, createdTime=Wed Apr 26 10:13:40 CST 2017, time=2017-04-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=190139, encodeId=5a401901392b, content=感谢分享一下, beContent=null, objectType=article, channel=null, level=null, likeNumber=57, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=1a161743757, createdName=zmjlilei, createdTime=Mon Apr 24 11:49:54 CST 2017, time=2017-04-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=189891, encodeId=5dbf189891a5, content=感谢分享一下, beContent=null, objectType=article, channel=null, level=null, likeNumber=21, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=1a161743757, createdName=zmjlilei, createdTime=Sun Apr 23 13:02:06 CST 2017, time=2017-04-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=189262, encodeId=14771892625b, content=感谢分享一下, beContent=null, objectType=article, channel=null, level=null, likeNumber=18, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=1a161743757, createdName=zmjlilei, createdTime=Fri Apr 21 07:46:28 CST 2017, time=2017-04-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=189010, encodeId=567b189010c8, content=感谢分享一下, beContent=null, objectType=article, channel=null, level=null, likeNumber=21, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=1a161743757, createdName=zmjlilei, createdTime=Thu Apr 20 08:29:35 CST 2017, time=2017-04-20, status=1, ipAttribution=)]
    2017-04-21 zmjlilei

    感谢分享一下

    0

  10. [GetPortalCommentsPageByObjectIdResponse(id=1654710, encodeId=edf21654e1076, content=<a href='/topic/show?id=edc610251468' target=_blank style='color:#2F92EE;'>#高甘油三酯#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=40, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=102514, encryptionId=edc610251468, topicName=高甘油三酯)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f5a424532179, createdName=flyingeagle85, createdTime=Thu Jun 08 23:23:00 CST 2017, time=2017-06-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2088942, encodeId=24fc20889427c, content=<a href='/topic/show?id=cbe6820410' target=_blank style='color:#2F92EE;'>#GPIHBP1#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=8204, encryptionId=cbe6820410, topicName=GPIHBP1)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4a4d285, createdName=日月, createdTime=Fri Sep 01 05:23:00 CST 2017, time=2017-09-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=191706, encodeId=241d191e06d1, content=感谢分享一下, beContent=null, objectType=article, channel=null, level=null, likeNumber=72, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=1a161743757, createdName=zmjlilei, createdTime=Sat Apr 29 07:12:44 CST 2017, time=2017-04-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=191390, encodeId=8f7e1913901c, content=感谢分享一下, beContent=null, objectType=article, channel=null, level=null, likeNumber=66, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=1a161743757, createdName=zmjlilei, createdTime=Fri Apr 28 08:47:16 CST 2017, time=2017-04-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=191102, encodeId=c06f191102f5, content=感谢分享一下, beContent=null, objectType=article, channel=null, level=null, likeNumber=68, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=1a161743757, createdName=zmjlilei, createdTime=Thu Apr 27 14:49:47 CST 2017, time=2017-04-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=190731, encodeId=6e06190e31bf, content=感谢分享一下, beContent=null, objectType=article, channel=null, level=null, likeNumber=62, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=1a161743757, createdName=zmjlilei, createdTime=Wed Apr 26 10:13:40 CST 2017, time=2017-04-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=190139, encodeId=5a401901392b, content=感谢分享一下, beContent=null, objectType=article, channel=null, level=null, likeNumber=57, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=1a161743757, createdName=zmjlilei, createdTime=Mon Apr 24 11:49:54 CST 2017, time=2017-04-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=189891, encodeId=5dbf189891a5, content=感谢分享一下, beContent=null, objectType=article, channel=null, level=null, likeNumber=21, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=1a161743757, createdName=zmjlilei, createdTime=Sun Apr 23 13:02:06 CST 2017, time=2017-04-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=189262, encodeId=14771892625b, content=感谢分享一下, beContent=null, objectType=article, channel=null, level=null, likeNumber=18, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=1a161743757, createdName=zmjlilei, createdTime=Fri Apr 21 07:46:28 CST 2017, time=2017-04-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=189010, encodeId=567b189010c8, content=感谢分享一下, beContent=null, objectType=article, channel=null, level=null, likeNumber=21, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=1a161743757, createdName=zmjlilei, createdTime=Thu Apr 20 08:29:35 CST 2017, time=2017-04-20, status=1, ipAttribution=)]
    2017-04-20 zmjlilei

    感谢分享一下

    0

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