Gastric Cancer:糖尿病与患胃癌的风险增加有关

2019-12-29 不详 MedSci原创

糖尿病(DM)被认为是胃癌的潜在危险因素,因此本项研究旨在通过比较基线和随访期间的内窥镜检查评估队列中DM与胃癌的相关性。

背景
糖尿病(DM)被认为是癌的潜在危险因素,因此本项研究旨在通过比较基线和随访期间的内窥镜检查评估队列中DM与癌的相关性。

方法
研究人员对2003年至2014年在基线和随访期间接受内镜检查的195312名成年男性和女性进行了一项回顾性队列研究。DM被定义为空腹血糖≥126mg/dL,自我报告的DM历史或当前使用情况抗糖尿病药物。

结果
DM在基线时的患病率为3.0%(n=5774)。在超过865511人年的随访时间中,有198名参与者患了胃癌。与基线时有或没有DM的参与者相比,发生胃癌的完全调整后的危险比(HR)为1.76[95%置信区间(CI)1.04-2.97;P=0.033)。当我们将DM评估为随时间变化的协变量时,完全调整的HR为1.66(95%CI 1.04–2.68;P=0.036)。DM与肠胃癌的相关性因肠上皮化生而无差异(P=0.61)。

结论
DM与胃癌的发病率增加独立相关。增加的风险与粘膜萎缩和肠上皮化生无关。DM患者可能需要更深入的内镜随访以筛查胃癌。

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    2020-01-09 许安
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    2020-10-26 skhzy
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    2019-12-29 misszhang

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