Int J Med Sci:下颌骨牵张成骨过程中,感觉神经的丧失可影响新骨的生成

2019-07-27 sunshine 译 MedSci原创

本研究旨在探讨下牙槽神经对兔下颌骨牵张成骨新骨形成的影响。20只新西兰白兔进行双侧牵张成骨,牵张率为1 mm /天。在手术显微镜下切除一侧下牙槽神经,下牙槽血管完整。对侧接受假手术。在28天的巩固期后处死兔子。再生愈伤组织进行X线检查,双能X线骨密度仪,苏木精和伊红染色以及组织形态学分析。使用SPSS 16.0软件包进行配对t检验。结果显示,下颌骨去神经支撑侧牵张间隙新骨的BMD明显低于对照组(P

本研究旨在探讨下牙槽神经对兔下颌骨牵张成骨新骨形成的影响。

20只新西兰白兔进行双侧牵张成骨,牵张率为1 mm /天。在手术显微镜下切除一侧下牙槽神经,下牙槽血管完整。对侧接受假手术。在28天的巩固期后处死兔子。再生愈伤组织进行X线检查,双能X线骨密度仪,苏木精和伊红染色以及组织形态学分析。使用SPSS 16.0软件包进行配对t检验。

结果显示,下颌骨去神经支撑侧牵张间隙新骨的BMD明显低于对照组(P <0.05)。组织学研究表明,骨小梁在去神经支配侧排列含有分散的软骨细胞,而骨小梁则有序,血管丰富,对照侧没有软骨细胞。去神经支配侧新骨量和新骨小梁厚度均明显低于对照组(P <0.05)。

综上所述,该研究结果表明,在下颌骨牵张成骨过程中,感觉神经的丧失可导致新骨质量下降。

原始出处:

Cao J, Zhang S, et al., Sensory Nerves Affect Bone Regeneration in Rabbit Mandibular Distraction Osteogenesis. Int J Med Sci. 2019 Jun 2;16(6):831-837. doi: 10.7150/ijms.31883. eCollection 2019.

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    2020-06-25 xlysu
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    2019-07-29 zhaojie88
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    2019-07-29 珙桐
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  7. [GetPortalCommentsPageByObjectIdResponse(id=1924432, encodeId=aad31924432e8, content=<a href='/topic/show?id=542f6e8439e' target=_blank style='color:#2F92EE;'>#牵张成骨#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=33, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=67843, encryptionId=542f6e8439e, topicName=牵张成骨)], attachment=null, authenticateStatus=null, createdAvatar=https://thirdwx.qlogo.cn/mmopen/vi_32/DYAIOgq83eoNX3lUOlDKGBUEPNwZx0nibmdcFyeibnX4WMhUSCU2REpGRWtSmnT2CCs0dA5waxvJknYDxwtYnIcQ/132, createdBy=294e2500218, createdName=ms3046638856685384, createdTime=Sun Apr 12 20:12:00 CST 2020, time=2020-04-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1703785, encodeId=36221e0378507, content=<a href='/topic/show?id=6a2d53396e2' target=_blank style='color:#2F92EE;'>#感觉神经#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=33, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=53396, encryptionId=6a2d53396e2, topicName=感觉神经)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=62d530584661, createdName=chaojitidian, createdTime=Tue May 26 23:12:00 CST 2020, time=2020-05-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1699779, encodeId=4de71699e7937, content=<a href='/topic/show?id=dd152024130' target=_blank style='color:#2F92EE;'>#下颌#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=20241, encryptionId=dd152024130, topicName=下颌)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=1c4f29973299, createdName=xlysu, createdTime=Thu Jun 25 06:12:00 CST 2020, time=2020-06-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1352192, encodeId=0f1b13521922a, content=<a href='/topic/show?id=e95954093cd' target=_blank style='color:#2F92EE;'>#成骨#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=22, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=54093, encryptionId=e95954093cd, topicName=成骨)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4c37265, createdName=zhaojie88, createdTime=Mon Jul 29 14:12:00 CST 2019, time=2019-07-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1419651, encodeId=cb7714196514c, content=<a href='/topic/show?id=e2dc2025888' target=_blank style='color:#2F92EE;'>#下颌骨#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=24, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=20258, encryptionId=e2dc2025888, topicName=下颌骨)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=d9f63514434, createdName=珙桐, createdTime=Mon Jul 29 14:12:00 CST 2019, time=2019-07-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1609885, encodeId=be3a160988548, content=<a href='/topic/show?id=eb6b1145939' target=_blank style='color:#2F92EE;'>#Med#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=19, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11459, encryptionId=eb6b1145939, topicName=Med)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=552a19396740, createdName=ms3994565386320060, createdTime=Mon Jul 29 14:12:00 CST 2019, time=2019-07-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=370378, encodeId=55c73e03788d, content=学习学习学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=51, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4NfNLvzZhgPxRkia1DP5MpwEgtXo1XhXA11xD6MWKxunAZFXKSNic0fWHUQx83oNHPlRMxxIctM83QKeCLkJpMibibiaC/0, createdBy=7e581734408, createdName=深海的鱼, createdTime=Sun Jul 28 06:01:44 CST 2019, time=2019-07-28, status=1, ipAttribution=)]
    2019-07-28 深海的鱼

    学习学习学习

    0