Arch Dermatol：吸烟导致患皮肤鳞状细胞癌风险增加

近日，一项刊登在Archives of Dermatology杂志上的研究证实：吸烟似乎与皮肤鳞状细胞癌皮肤癌的风险增加有关。

无论是基底细胞癌（基底细胞癌）或鳞状细胞癌（鳞癌）还是非黑色素瘤皮肤癌（NMSC），约97％的皮肤癌起源于上皮细胞（包括皮肤细胞）。在世界范围内NMSC的发病率不断增加，每年估计有200万到300万的新发病例。

英国烟草控制研究中心、英国诺丁汉大学Jo Leonardi-Bee博士和他的同事纳入25项研究，对吸烟与皮肤鳞状细胞癌风险之间的关系进行了分析研究。这个系统回顾和荟萃分析研究结果显示吸烟和皮肤鳞状细胞癌之间有密切关系，吸烟会导致皮肤鳞状细胞癌风险增加52％。

研究人员得出结论认为：这项研究非常具有临床重要性，为识别早期皮肤癌，及早诊断并采取预防措施可明显改善患者预后情况。

doi:10.1001/archdermatol.2012.1374
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Smoking and the Risk of Nonmelanoma Skin CancerSystematic Review and Meta-analysis

Jo Leonardi-Bee, PhD; Thomas Ellison, BMedSci; Fiona Bath-Hextall, PhD

Objective To perform a systematic review and meta-analysis to collate evidence of the effects of smoking on the risk of nonmelanoma skin cancer.

Data Sources We searched 4 electronic databases (from inception to October 2010) and scanned the reference lists of the publications retrieved to identify eligible comparative epidemiologic studies.

Study Selection Titles, abstracts, and full text were assessed independently by 2 authors against prespecified inclusion/exclusion criteria.

Data Extraction Data were extracted and quality was assessed independently by 2 authors using the Newcastle-Ottawa Scale.

Data Synthesis Meta-analysis was performed using random-effects models. Results are presented as odds ratios (ORs) with 95% CIs. Heterogeneity was assessed using I². Twenty-five studies were included. Smoking was significantly associated with cutaneous squamous cell carcinoma (OR, 1.52; 95% CI, 1.15-2.01; I² = 64%; 6 studies). Smoking was not significantly associated with basal cell carcinoma (OR, 0.95; 95% CI, 0.82-1.09; I² = 59%; 14 studies) or nonmelanoma skin cancer (OR, 0.62; 95% CI, 0.21-1.79; I² = 34%; 2 studies).

Conclusion This study clearly demonstrates that smoking increases the risk of cutaneous squamous cell carcinoma; however, smoking does not appear to modify the risk of basal cell carcinoma.