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BMJ Open：DPP4抑制剂降糖效果或在第二年减弱

2014-07-10 伊文 中华医学会糖尿病学分会

DPP4抑制剂降糖效果
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一项最新Meta分析表明，在2型糖尿病患者中，DPP4抑制剂对HbA1c水平的控制效果在第二年会明显减弱。 该分析纳入12项研究、14829例受试者，每项研究至少持续76周。研究结束时和研究中期的HbA1c水平降幅差为0.22%，说明治疗第2年时DPP4抑制剂的疗效有所减弱。研究者表示，本项研究提示未来的研究应关注DPP4抑制剂对2型糖尿病患者治疗的特点，已获得最大受益。原始出处：Kat

一项最新Meta分析表明，在2型糖尿病患者中，DPP4抑制剂对HbA1c水平的控制效果在第二年会明显减弱。

该分析纳入12项研究、14829例受试者，每项研究至少持续76周。研究结束时和研究中期的HbA1c水平降幅差为0.22%，说明治疗第2年时DPP4抑制剂的疗效有所减弱。研究者表示，本项研究提示未来的研究应关注DPP4抑制剂对2型糖尿病患者治疗的特点，已获得最大受益。

原始出处：

Katherine Esposito1, Paolo Chiodini2, Maria Ida Maiorino3, Giuseppe Bellastella3, Annalisa Capuano4, Dario Giugliano3.Glycaemic durability with dipeptidyl peptidase-4 inhibitors in type 2 diabetes: a systematic review and meta-analysis of long-term randomised controlled trials.BMJ Open 2014;4:e005442 doi:10.1136/bmjopen-2014-005442 


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  1. [GetPortalCommentsPageByObjectIdResponse(id=1851186, encodeId=ef1d185118653, content=<a href='/topic/show?id=f0a254918f0' target=_blank style='color:#2F92EE;'>#抑制剂#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=24, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=54918, encryptionId=f0a254918f0, topicName=抑制剂)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=44a360, createdName=jklm09, createdTime=Fri Jul 25 21:15:00 CST 2014, time=2014-07-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=20710, encodeId=ca3a20e10cc, content=糖尿病肾病进展风险的关系没有发现。, beContent=null, objectType=article, channel=null, level=null, likeNumber=109, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20150920/IMG55FDE671A89482379.jpg, createdBy=cef3108336, createdName=x35042875, createdTime=Sat Apr 11 23:32:00 CST 2015, time=2015-04-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1847597, encodeId=bacd184e59770, content=<a href='/topic/show?id=2977356edc' target=_blank style='color:#2F92EE;'>#BMJ#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=3567, encryptionId=2977356edc, topicName=BMJ)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=148754, createdName=gaoxiaoe, createdTime=Thu Dec 25 00:15:00 CST 2014, time=2014-12-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1943584, encodeId=30fa1943584f6, content=<a href='/topic/show?id=a0876221eb' target=_blank style='color:#2F92EE;'>#DPP4抑制剂#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=41, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=6221, encryptionId=a0876221eb, topicName=DPP4抑制剂)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=65c7309, createdName=fengxx, createdTime=Wed Feb 04 06:15:00 CST 2015, time=2015-02-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1951206, encodeId=3a9f195120654, content=<a href='/topic/show?id=e6fa981e4df' target=_blank style='color:#2F92EE;'>#降糖效果#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=98174, encryptionId=e6fa981e4df, topicName=降糖效果)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=827b160, createdName=cnxcy, createdTime=Tue Jan 20 17:15:00 CST 2015, time=2015-01-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1725635, encodeId=55381e256356d, content=<a href='/topic/show?id=986913980dd' target=_blank style='color:#2F92EE;'>#PE#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=22, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=13980, encryptionId=986913980dd, topicName=PE)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f06c33759375, createdName=feather89, createdTime=Thu Aug 28 10:15:00 CST 2014, time=2014-08-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1625211, encodeId=137e1625211b6, content=<a href='/topic/show?id=29ff621976' target=_blank style='color:#2F92EE;'>#DPP4#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=6219, encryptionId=29ff621976, topicName=DPP4)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=99a420702434, createdName=oliver176, createdTime=Sat Jul 12 07:15:00 CST 2014, time=2014-07-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=10426, encodeId=ea8310426b5, content=这个坑也太大了吧。是不是因为耐药，因为DDP4i对胰高血糖素等形成负反馈，从而减弱其作用？, beContent=null, objectType=article, channel=null, level=null, likeNumber=107, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20220519/c2ab253484ee4527a2d4e9589a4821ac/45de9bf494a54becb2ea4369c9d11e85.jpg, createdBy=7a3710, createdName=lovetcm, createdTime=Fri Jul 11 21:15:00 CST 2014, time=2014-07-11, status=1, ipAttribution=)]
    2014-07-25 jklm09

    #抑制剂#

    0

  2. [GetPortalCommentsPageByObjectIdResponse(id=1851186, encodeId=ef1d185118653, content=<a href='/topic/show?id=f0a254918f0' target=_blank style='color:#2F92EE;'>#抑制剂#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=24, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=54918, encryptionId=f0a254918f0, topicName=抑制剂)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=44a360, createdName=jklm09, createdTime=Fri Jul 25 21:15:00 CST 2014, time=2014-07-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=20710, encodeId=ca3a20e10cc, content=糖尿病肾病进展风险的关系没有发现。, beContent=null, objectType=article, channel=null, level=null, likeNumber=109, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20150920/IMG55FDE671A89482379.jpg, createdBy=cef3108336, createdName=x35042875, createdTime=Sat Apr 11 23:32:00 CST 2015, time=2015-04-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1847597, encodeId=bacd184e59770, content=<a href='/topic/show?id=2977356edc' target=_blank style='color:#2F92EE;'>#BMJ#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=3567, encryptionId=2977356edc, topicName=BMJ)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=148754, createdName=gaoxiaoe, createdTime=Thu Dec 25 00:15:00 CST 2014, time=2014-12-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1943584, encodeId=30fa1943584f6, content=<a href='/topic/show?id=a0876221eb' target=_blank style='color:#2F92EE;'>#DPP4抑制剂#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=41, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=6221, encryptionId=a0876221eb, topicName=DPP4抑制剂)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=65c7309, createdName=fengxx, createdTime=Wed Feb 04 06:15:00 CST 2015, time=2015-02-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1951206, encodeId=3a9f195120654, content=<a href='/topic/show?id=e6fa981e4df' target=_blank style='color:#2F92EE;'>#降糖效果#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=98174, encryptionId=e6fa981e4df, topicName=降糖效果)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=827b160, createdName=cnxcy, createdTime=Tue Jan 20 17:15:00 CST 2015, time=2015-01-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1725635, encodeId=55381e256356d, content=<a href='/topic/show?id=986913980dd' target=_blank style='color:#2F92EE;'>#PE#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=22, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=13980, encryptionId=986913980dd, topicName=PE)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f06c33759375, createdName=feather89, createdTime=Thu Aug 28 10:15:00 CST 2014, time=2014-08-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1625211, encodeId=137e1625211b6, content=<a href='/topic/show?id=29ff621976' target=_blank style='color:#2F92EE;'>#DPP4#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=6219, encryptionId=29ff621976, topicName=DPP4)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=99a420702434, createdName=oliver176, createdTime=Sat Jul 12 07:15:00 CST 2014, time=2014-07-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=10426, encodeId=ea8310426b5, content=这个坑也太大了吧。是不是因为耐药，因为DDP4i对胰高血糖素等形成负反馈，从而减弱其作用？, beContent=null, objectType=article, channel=null, level=null, likeNumber=107, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20220519/c2ab253484ee4527a2d4e9589a4821ac/45de9bf494a54becb2ea4369c9d11e85.jpg, createdBy=7a3710, createdName=lovetcm, createdTime=Fri Jul 11 21:15:00 CST 2014, time=2014-07-11, status=1, ipAttribution=)]
    2015-04-11 x35042875

    糖尿病肾病进展风险的关系没有发现。

    0

  3. [GetPortalCommentsPageByObjectIdResponse(id=1851186, encodeId=ef1d185118653, content=<a href='/topic/show?id=f0a254918f0' target=_blank style='color:#2F92EE;'>#抑制剂#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=24, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=54918, encryptionId=f0a254918f0, topicName=抑制剂)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=44a360, createdName=jklm09, createdTime=Fri Jul 25 21:15:00 CST 2014, time=2014-07-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=20710, encodeId=ca3a20e10cc, content=糖尿病肾病进展风险的关系没有发现。, beContent=null, objectType=article, channel=null, level=null, likeNumber=109, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20150920/IMG55FDE671A89482379.jpg, createdBy=cef3108336, createdName=x35042875, createdTime=Sat Apr 11 23:32:00 CST 2015, time=2015-04-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1847597, encodeId=bacd184e59770, content=<a href='/topic/show?id=2977356edc' target=_blank style='color:#2F92EE;'>#BMJ#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=3567, encryptionId=2977356edc, topicName=BMJ)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=148754, createdName=gaoxiaoe, createdTime=Thu Dec 25 00:15:00 CST 2014, time=2014-12-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1943584, encodeId=30fa1943584f6, content=<a href='/topic/show?id=a0876221eb' target=_blank style='color:#2F92EE;'>#DPP4抑制剂#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=41, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=6221, encryptionId=a0876221eb, topicName=DPP4抑制剂)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=65c7309, createdName=fengxx, createdTime=Wed Feb 04 06:15:00 CST 2015, time=2015-02-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1951206, encodeId=3a9f195120654, content=<a href='/topic/show?id=e6fa981e4df' target=_blank style='color:#2F92EE;'>#降糖效果#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=98174, encryptionId=e6fa981e4df, topicName=降糖效果)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=827b160, createdName=cnxcy, createdTime=Tue Jan 20 17:15:00 CST 2015, time=2015-01-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1725635, encodeId=55381e256356d, content=<a href='/topic/show?id=986913980dd' target=_blank style='color:#2F92EE;'>#PE#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=22, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=13980, encryptionId=986913980dd, topicName=PE)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f06c33759375, createdName=feather89, createdTime=Thu Aug 28 10:15:00 CST 2014, time=2014-08-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1625211, encodeId=137e1625211b6, content=<a href='/topic/show?id=29ff621976' target=_blank style='color:#2F92EE;'>#DPP4#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=6219, encryptionId=29ff621976, topicName=DPP4)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=99a420702434, createdName=oliver176, createdTime=Sat Jul 12 07:15:00 CST 2014, time=2014-07-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=10426, encodeId=ea8310426b5, content=这个坑也太大了吧。是不是因为耐药，因为DDP4i对胰高血糖素等形成负反馈，从而减弱其作用？, beContent=null, objectType=article, channel=null, level=null, likeNumber=107, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20220519/c2ab253484ee4527a2d4e9589a4821ac/45de9bf494a54becb2ea4369c9d11e85.jpg, createdBy=7a3710, createdName=lovetcm, createdTime=Fri Jul 11 21:15:00 CST 2014, time=2014-07-11, status=1, ipAttribution=)]
    2014-12-25 gaoxiaoe

    #BMJ#

    0

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    2015-02-04 fengxx

    #DPP4抑制剂#

    0

  5. [GetPortalCommentsPageByObjectIdResponse(id=1851186, encodeId=ef1d185118653, content=<a href='/topic/show?id=f0a254918f0' target=_blank style='color:#2F92EE;'>#抑制剂#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=24, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=54918, encryptionId=f0a254918f0, topicName=抑制剂)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=44a360, createdName=jklm09, createdTime=Fri Jul 25 21:15:00 CST 2014, time=2014-07-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=20710, encodeId=ca3a20e10cc, content=糖尿病肾病进展风险的关系没有发现。, beContent=null, objectType=article, channel=null, level=null, likeNumber=109, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20150920/IMG55FDE671A89482379.jpg, createdBy=cef3108336, createdName=x35042875, createdTime=Sat Apr 11 23:32:00 CST 2015, time=2015-04-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1847597, encodeId=bacd184e59770, content=<a href='/topic/show?id=2977356edc' target=_blank style='color:#2F92EE;'>#BMJ#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=3567, encryptionId=2977356edc, topicName=BMJ)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=148754, createdName=gaoxiaoe, createdTime=Thu Dec 25 00:15:00 CST 2014, time=2014-12-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1943584, encodeId=30fa1943584f6, content=<a href='/topic/show?id=a0876221eb' target=_blank style='color:#2F92EE;'>#DPP4抑制剂#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=41, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=6221, encryptionId=a0876221eb, topicName=DPP4抑制剂)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=65c7309, createdName=fengxx, createdTime=Wed Feb 04 06:15:00 CST 2015, time=2015-02-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1951206, encodeId=3a9f195120654, content=<a href='/topic/show?id=e6fa981e4df' target=_blank style='color:#2F92EE;'>#降糖效果#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=98174, encryptionId=e6fa981e4df, topicName=降糖效果)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=827b160, createdName=cnxcy, createdTime=Tue Jan 20 17:15:00 CST 2015, time=2015-01-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1725635, encodeId=55381e256356d, content=<a href='/topic/show?id=986913980dd' target=_blank style='color:#2F92EE;'>#PE#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=22, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=13980, encryptionId=986913980dd, topicName=PE)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f06c33759375, createdName=feather89, createdTime=Thu Aug 28 10:15:00 CST 2014, time=2014-08-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1625211, encodeId=137e1625211b6, content=<a href='/topic/show?id=29ff621976' target=_blank style='color:#2F92EE;'>#DPP4#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=6219, encryptionId=29ff621976, topicName=DPP4)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=99a420702434, createdName=oliver176, createdTime=Sat Jul 12 07:15:00 CST 2014, time=2014-07-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=10426, encodeId=ea8310426b5, content=这个坑也太大了吧。是不是因为耐药，因为DDP4i对胰高血糖素等形成负反馈，从而减弱其作用？, beContent=null, objectType=article, channel=null, level=null, likeNumber=107, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20220519/c2ab253484ee4527a2d4e9589a4821ac/45de9bf494a54becb2ea4369c9d11e85.jpg, createdBy=7a3710, createdName=lovetcm, createdTime=Fri Jul 11 21:15:00 CST 2014, time=2014-07-11, status=1, ipAttribution=)]
    2015-01-20 cnxcy

    #降糖效果#

    0

  6. [GetPortalCommentsPageByObjectIdResponse(id=1851186, encodeId=ef1d185118653, content=<a href='/topic/show?id=f0a254918f0' target=_blank style='color:#2F92EE;'>#抑制剂#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=24, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=54918, encryptionId=f0a254918f0, topicName=抑制剂)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=44a360, createdName=jklm09, createdTime=Fri Jul 25 21:15:00 CST 2014, time=2014-07-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=20710, encodeId=ca3a20e10cc, content=糖尿病肾病进展风险的关系没有发现。, beContent=null, objectType=article, channel=null, level=null, likeNumber=109, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20150920/IMG55FDE671A89482379.jpg, createdBy=cef3108336, createdName=x35042875, createdTime=Sat Apr 11 23:32:00 CST 2015, time=2015-04-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1847597, encodeId=bacd184e59770, content=<a href='/topic/show?id=2977356edc' target=_blank style='color:#2F92EE;'>#BMJ#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=3567, encryptionId=2977356edc, topicName=BMJ)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=148754, createdName=gaoxiaoe, createdTime=Thu Dec 25 00:15:00 CST 2014, time=2014-12-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1943584, encodeId=30fa1943584f6, content=<a href='/topic/show?id=a0876221eb' target=_blank style='color:#2F92EE;'>#DPP4抑制剂#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=41, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=6221, encryptionId=a0876221eb, topicName=DPP4抑制剂)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=65c7309, createdName=fengxx, createdTime=Wed Feb 04 06:15:00 CST 2015, time=2015-02-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1951206, encodeId=3a9f195120654, content=<a href='/topic/show?id=e6fa981e4df' target=_blank style='color:#2F92EE;'>#降糖效果#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=98174, encryptionId=e6fa981e4df, topicName=降糖效果)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=827b160, createdName=cnxcy, createdTime=Tue Jan 20 17:15:00 CST 2015, time=2015-01-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1725635, encodeId=55381e256356d, content=<a href='/topic/show?id=986913980dd' target=_blank style='color:#2F92EE;'>#PE#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=22, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=13980, encryptionId=986913980dd, topicName=PE)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f06c33759375, createdName=feather89, createdTime=Thu Aug 28 10:15:00 CST 2014, time=2014-08-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1625211, encodeId=137e1625211b6, content=<a href='/topic/show?id=29ff621976' target=_blank style='color:#2F92EE;'>#DPP4#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=6219, encryptionId=29ff621976, topicName=DPP4)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=99a420702434, createdName=oliver176, createdTime=Sat Jul 12 07:15:00 CST 2014, time=2014-07-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=10426, encodeId=ea8310426b5, content=这个坑也太大了吧。是不是因为耐药，因为DDP4i对胰高血糖素等形成负反馈，从而减弱其作用？, beContent=null, objectType=article, channel=null, level=null, likeNumber=107, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20220519/c2ab253484ee4527a2d4e9589a4821ac/45de9bf494a54becb2ea4369c9d11e85.jpg, createdBy=7a3710, createdName=lovetcm, createdTime=Fri Jul 11 21:15:00 CST 2014, time=2014-07-11, status=1, ipAttribution=)]
    2014-08-28 feather89

    #PE#

    0

  7. [GetPortalCommentsPageByObjectIdResponse(id=1851186, encodeId=ef1d185118653, content=<a href='/topic/show?id=f0a254918f0' target=_blank style='color:#2F92EE;'>#抑制剂#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=24, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=54918, encryptionId=f0a254918f0, topicName=抑制剂)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=44a360, createdName=jklm09, createdTime=Fri Jul 25 21:15:00 CST 2014, time=2014-07-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=20710, encodeId=ca3a20e10cc, content=糖尿病肾病进展风险的关系没有发现。, beContent=null, objectType=article, channel=null, level=null, likeNumber=109, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20150920/IMG55FDE671A89482379.jpg, createdBy=cef3108336, createdName=x35042875, createdTime=Sat Apr 11 23:32:00 CST 2015, time=2015-04-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1847597, encodeId=bacd184e59770, content=<a href='/topic/show?id=2977356edc' target=_blank style='color:#2F92EE;'>#BMJ#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=3567, encryptionId=2977356edc, topicName=BMJ)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=148754, createdName=gaoxiaoe, createdTime=Thu Dec 25 00:15:00 CST 2014, time=2014-12-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1943584, encodeId=30fa1943584f6, content=<a href='/topic/show?id=a0876221eb' target=_blank style='color:#2F92EE;'>#DPP4抑制剂#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=41, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=6221, encryptionId=a0876221eb, topicName=DPP4抑制剂)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=65c7309, createdName=fengxx, createdTime=Wed Feb 04 06:15:00 CST 2015, time=2015-02-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1951206, encodeId=3a9f195120654, content=<a href='/topic/show?id=e6fa981e4df' target=_blank style='color:#2F92EE;'>#降糖效果#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=98174, encryptionId=e6fa981e4df, topicName=降糖效果)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=827b160, createdName=cnxcy, createdTime=Tue Jan 20 17:15:00 CST 2015, time=2015-01-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1725635, encodeId=55381e256356d, content=<a href='/topic/show?id=986913980dd' target=_blank style='color:#2F92EE;'>#PE#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=22, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=13980, encryptionId=986913980dd, topicName=PE)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f06c33759375, createdName=feather89, createdTime=Thu Aug 28 10:15:00 CST 2014, time=2014-08-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1625211, encodeId=137e1625211b6, content=<a href='/topic/show?id=29ff621976' target=_blank style='color:#2F92EE;'>#DPP4#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=6219, encryptionId=29ff621976, topicName=DPP4)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=99a420702434, createdName=oliver176, createdTime=Sat Jul 12 07:15:00 CST 2014, time=2014-07-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=10426, encodeId=ea8310426b5, content=这个坑也太大了吧。是不是因为耐药，因为DDP4i对胰高血糖素等形成负反馈，从而减弱其作用？, beContent=null, objectType=article, channel=null, level=null, likeNumber=107, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20220519/c2ab253484ee4527a2d4e9589a4821ac/45de9bf494a54becb2ea4369c9d11e85.jpg, createdBy=7a3710, createdName=lovetcm, createdTime=Fri Jul 11 21:15:00 CST 2014, time=2014-07-11, status=1, ipAttribution=)]
    2014-07-12 oliver176

    #DPP4#

    0

  8. [GetPortalCommentsPageByObjectIdResponse(id=1851186, encodeId=ef1d185118653, content=<a href='/topic/show?id=f0a254918f0' target=_blank style='color:#2F92EE;'>#抑制剂#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=24, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=54918, encryptionId=f0a254918f0, topicName=抑制剂)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=44a360, createdName=jklm09, createdTime=Fri Jul 25 21:15:00 CST 2014, time=2014-07-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=20710, encodeId=ca3a20e10cc, content=糖尿病肾病进展风险的关系没有发现。, beContent=null, objectType=article, channel=null, level=null, likeNumber=109, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20150920/IMG55FDE671A89482379.jpg, createdBy=cef3108336, createdName=x35042875, createdTime=Sat Apr 11 23:32:00 CST 2015, time=2015-04-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1847597, encodeId=bacd184e59770, content=<a href='/topic/show?id=2977356edc' target=_blank style='color:#2F92EE;'>#BMJ#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=3567, encryptionId=2977356edc, topicName=BMJ)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=148754, createdName=gaoxiaoe, createdTime=Thu Dec 25 00:15:00 CST 2014, time=2014-12-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1943584, encodeId=30fa1943584f6, content=<a href='/topic/show?id=a0876221eb' target=_blank style='color:#2F92EE;'>#DPP4抑制剂#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=41, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=6221, encryptionId=a0876221eb, topicName=DPP4抑制剂)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=65c7309, createdName=fengxx, createdTime=Wed Feb 04 06:15:00 CST 2015, time=2015-02-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1951206, encodeId=3a9f195120654, content=<a href='/topic/show?id=e6fa981e4df' target=_blank style='color:#2F92EE;'>#降糖效果#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=98174, encryptionId=e6fa981e4df, topicName=降糖效果)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=827b160, createdName=cnxcy, createdTime=Tue Jan 20 17:15:00 CST 2015, time=2015-01-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1725635, encodeId=55381e256356d, content=<a href='/topic/show?id=986913980dd' target=_blank style='color:#2F92EE;'>#PE#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=22, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=13980, encryptionId=986913980dd, topicName=PE)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f06c33759375, createdName=feather89, createdTime=Thu Aug 28 10:15:00 CST 2014, time=2014-08-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1625211, encodeId=137e1625211b6, content=<a href='/topic/show?id=29ff621976' target=_blank style='color:#2F92EE;'>#DPP4#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=6219, encryptionId=29ff621976, topicName=DPP4)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=99a420702434, createdName=oliver176, createdTime=Sat Jul 12 07:15:00 CST 2014, time=2014-07-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=10426, encodeId=ea8310426b5, content=这个坑也太大了吧。是不是因为耐药，因为DDP4i对胰高血糖素等形成负反馈，从而减弱其作用？, beContent=null, objectType=article, channel=null, level=null, likeNumber=107, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20220519/c2ab253484ee4527a2d4e9589a4821ac/45de9bf494a54becb2ea4369c9d11e85.jpg, createdBy=7a3710, createdName=lovetcm, createdTime=Fri Jul 11 21:15:00 CST 2014, time=2014-07-11, status=1, ipAttribution=)]
    2014-07-11 lovetcm

    这个坑也太大了吧。是不是因为耐药，因为DDP4i对胰高血糖素等形成负反馈，从而减弱其作用？

    0