J Periodontol: 拉美裔人群牙周炎与转氨酶升高的研究

2018-08-19 MedSci MedSci原创

西班牙裔/拉美裔人群中,非酒精性脂肪性肝病(NAFLD)患病率比其他种族/族裔群体更高,据报道,西班牙裔/拉丁裔群体的患病率也有所不同。实验动物和人类研究表明牙周炎与NAFLD之间存在关联,但尚未在西班牙裔/拉丁美洲人中报道。本研究将牙周炎作为一种新的危险因素进行了研究,该因素可能导致西班牙裔/拉美裔人群中NAFLD的负担。

西班牙裔/拉美裔人群中,非酒精性脂肪性肝病(NAFLD)患病率比其他种族/族裔群体更高,据报道,西班牙裔/拉丁裔群体的患病率也有所不同。实验动物和人类研究表明牙周炎与NAFLD之间存在关联,但尚未在西班牙裔/拉丁美洲人中报道。本研究将牙周炎作为一种新的危险因素进行了研究,该因素可能导致西班牙裔/拉美裔人群中NAFLD的负担。

方法:实验纳入拉丁美洲/西班牙裔社区的11,914名参与者。牙周炎定义为牙周位点的范围(无,<30%,≥30%),临床附着水平(CAL)≥3mm或探诊深度(PD)≥4mm。指示疑似NAFLD的血清转氨酶升高定义为男性:丙氨酸氨基转移酶水平(ALT)> 40 IU / L或天冬氨酸氨基转移酶(AST)> 37 IU / L,女性:ALT> 31 IU / L或AST> 31 IU / L。 Survey-logistic回归模型估计牙周炎与疑似NAFLD之间关联的患病率优势比(POR)和95%置信区间(CI)。

结果:CAL> 3 mm或PD≥4mm的位点<30%的研究参与者的总体年龄标准化百分比分别为53.5%和58.6%,而≥30%的参与者,CAL≥3mm或PD≥4mm的患者分别为16%和5.72%。疑似NAFLD的总体年龄标准化患病率(95%CI)为18.1%(17.1-19.0)。对于整个队列,我们观察到PD≥4mm与疑似NAFLD的患病率之间的剂量反应(即分级)关联,其中受影响<30%的参与者的粗POR = 1.19(95%CI:1.03,1.38) )受影响≥30%的参与者的粗POR = 1.39(95%CI:1.02,1.90)。这些粗略估计值朝着零点减弱,并且在协变量调整时变得不显着。西班牙裔/拉美裔组没有发现任何差异。

结论:此前报道的牙周炎和NAFLD之间的关联在这项针对不同的西班牙裔/拉美裔群体的研究中是微不足道的。

原始出处:

Aderonke A., et al. Periodontitis and prevalence of elevated aminotransferases in the Hispanic Community Health Study/Study of Latinos. Journal of Periodontology. 2018 August. doi:10.1002/JPER.17-0579

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    2018-11-01 feather89
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    2018-08-19 明月清辉

    谢谢分享,学习了

    0

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J Periodontol: 拉美裔中牙周炎和氨基转移酶升高的关系

西班牙裔/拉丁裔中非酒精性脂肪肝(NAFLD)患病率高于其他种族/民族,并且西班牙裔/拉丁裔组间有差异。实验动物和人体研究证明牙周炎和NAFLD之间存在关联,而西班牙裔/拉美裔中尚未报道。这项研究检查了牙周炎可能是西班牙裔/拉美裔中NAFLD的一种新的危险因素。