Eur J Radiol:玩转DCE MRI之半定量动态增强MRI在评估前列腺癌特点和分级的价值!

2017-08-04 shaosai MedSci原创

前列腺癌是指发生在前列腺的上皮性恶性肿瘤。2004年WHO《泌尿系统及男性生殖器官肿瘤病理学和遗传学》中前列腺癌病理类型上包括腺癌(腺泡腺癌)、导管腺癌、尿路上皮癌、鳞状细胞癌、腺鳞癌。其中前列腺腺癌占95%以上,因此,通常我们所说的前列腺癌就是指前列腺腺癌。2012年我国肿瘤登记地区前列腺癌发病率为9.92/10万,列男性恶性肿瘤发病率的第6位。发病年龄在55岁前处于较低水平,55岁后逐渐升高,

前列腺癌是指发生在前列腺的上皮性恶性肿瘤。2004年WHO《泌尿系统及男性生殖器官肿瘤病理学和遗传学》中前列腺癌病理类型上包括腺癌(腺泡腺癌)、导管腺癌、尿路上皮癌、鳞状细胞癌、腺鳞癌。其中前列腺腺癌占95%以上,因此,通常我们所说的前列腺癌就是指前列腺腺癌。2012年我国肿瘤登记地区前列腺癌发病率为9.92/10万,列男性恶性肿瘤发病率的第6位。发病年龄在55岁前处于较低水平,55岁后逐渐升高,发病率随着年龄的增长而增长,高峰年龄是70~80岁。家族遗传型前列腺癌患者发病年龄稍早,年龄≤55岁的患者占43%。本研究回顾性评估利用半定量动态增强(DCE)磁共振(MRI)在前列腺癌影像学特征和分级的价值,以及与病理学诊断相关性的分析,并将结果发表在Eur J Radiol上。

本研究共纳入了161例前列腺癌并行DCE MRI的患者。共有430处病灶,其中包括200处肿瘤病变(Gleason分级(GG)为6级=25,7级=112,8级以上=63);80处良性前列腺增生和150处正常前列腺组织并行活检-MRI诊断相关性分析。两位放射科医生评估的时间信号强度曲线和kinetic参数在不同组织类型和GGs进行比较。利用ROC曲线分析来评估鉴别肿瘤与良性前列腺增生、正常组织以及GG8以上与GG7或7差异的能力。

结果为,类型2是比较普遍的曲线类型。观察间的曲线类型的一致性优秀。与正常组织和GG6相比,前列腺癌和GG8具有明显高的Cpeakh和更快的流入曲线。肿瘤与正常组织、GG6和GG8以上级别相比,只有流入型曲线能够明显地在鉴别中有统计学差异,相应曲线下面积(AUC)分别为0.755、0.815。流入型曲线结合动态增强2个参数(C peak)和3个参数(C peak and wash-out)的AUC分别为0.791和 0.839、0.862和0.891。

本研究表明,DCE MRI半定量参数能够鉴别前列腺良性增生和正常组织。流入型曲线是鉴别肿瘤和GG8以上级别的病变最准确的参数。

原始出处:

Kim SH, Choi MS, Kim MJ, et al,Role of semi-quantitative dynamic contrast-enhanced MR imaging in characterization and grading of prostate cancer. Eur J Radiol. 2017.DOI: 10.1016/j.ejrad.2017.06.021

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    2017-08-05 明月清辉

    谢谢分享,学习了

    0

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    2017-08-05 Y—xianghai

    学习了新知识

    0

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    2017-08-05 刘煜

    学习了谢谢分享

    0

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    学习学习学习

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    学习学习学习

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