JID:不易晒黑+HPV抗体阳性,皮肤癌风险增加

2012-06-17 高晓方 翻译 中国医学论坛报

  紫外线照射及皮肤人乳头状瘤病毒(HPV)感染或对皮肤基底细胞癌(BCC)和鳞状细胞癌(SCC)的发生具协同交互作用。美国一项研究显示,对于α属或β属HPV血清抗体阳性者,若不易晒黑,则罹患皮肤SCC风险较高。论文于6月1日在线发表于《感染性疾病杂志》(J Infect Dis)。   研究纳入皮肤BCC患者204例,皮肤SCC患者156例,以及无肿瘤病史且当前皮肤癌筛查为阴性的对照297名。评

  紫外线照射及皮肤人乳头状瘤病毒(HPV)感染或对皮肤基底细胞癌(BCC)和鳞状细胞癌(SCC)的发生具协同交互作用。美国一项研究显示,对于α属或β属HPV血清抗体阳性者,若不易晒黑,则罹患皮肤SCC风险较高。论文于6月1日在线发表于《感染性疾病杂志》(J Infect Dis)。
  研究纳入皮肤BCC患者204例,皮肤SCC患者156例,以及无肿瘤病史且当前皮肤癌筛查为阴性的对照297名。评估日光暴露与皮肤BCC和SCC的相关性,并根据HPV血清学状况进行分层。
  结果为,皮肤对日光暴露敏感[易晒伤(P=0.006)及不易晒黑(P=0.003)]与β属HPV血清阳性率较高相关。与血清阴性者相比,对于α属[比值比(OR)为15.60]和β属(OR=6.86)HPV血清抗体阳性的个体,不易晒黑与SCC具有更强的相关性。


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    2012-06-27 sjq027
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    2012-09-09 紫砂壶
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