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Cell Reports ：治疗 2 型糖尿病的新途径

2021-06-30 MedSci原创 MedSci原创

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肝脏可能是新的、预防性 2 型糖尿病治疗的关键，研究员发现肝脏中的脂肪增加了抑制性神经递质γ-氨基丁酸或 GABA 的释放。

糖尿病是全球死亡的主要原因之一，据国际糖尿病联合会（IDF）2019年数据预测，到2045年，全球糖尿病患者将增长51%，达到7亿。2 型糖尿病的患病率是 1 型糖尿病的 24 倍。目前所有针对 2 型糖尿病的治疗方法主要旨在降低血糖。 近期发表在Cell Reports 上的一项研究表明，肝脏可能是新的、预防性 2 型糖尿病治疗的关键，研究员发现肝脏中的脂肪增加了抑制性神经递质γ-氨基丁酸或 GABA 的释放。 肝脏脂肪变性是 T2D 的一个标志，因为肝脏脂质的积累与外周胰岛素抵抗和高胰岛素血症的严重程度密切相关。此外，87% 的糖尿病患者超重或肥胖。 在该研究中，为了确定肝脏 GABA 合成增加是否导致胰岛素抵抗，研究员采用了两种模型来限制肝脏 GABA 的产生：（1）GABA-T 活性的药理学抑制和（2）反义寡核苷酸（ASO）介导的肝脏特异性 GABA-T 表达的敲低。使用这些模型，研究员评估了全身葡萄糖稳态，以检查肥胖诱导的肝脏 GABA 产生与肥胖诱导的高胰岛素血症和胰岛素抵抗之间的因果作用。此外，他们还评估了食物摄入和能量消耗，以了解肝脏 GABA 产生在肥胖能量稳态失调中

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    2022-01-29 caobinglei8079

    #新途径#

    0

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    2022-05-25 维他命

    #CEL#

    0

  3. [GetPortalCommentsPageByObjectIdResponse(id=1953402, encodeId=6caa1953402e2, content=<a href='/topic/show?id=edbb58e115a' target=_blank style='color:#2F92EE;'>#新途径#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=58711, encryptionId=edbb58e115a, topicName=新途径)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=5e30378, createdName=caobinglei8079, createdTime=Sat Jan 29 17:43:55 CST 2022, time=2022-01-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1962554, encodeId=5b0e196255433, content=<a href='/topic/show?id=dbe6445416' target=_blank style='color:#2F92EE;'>#CEL#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=4454, encryptionId=dbe6445416, topicName=CEL)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c3ff68, createdName=维他命, createdTime=Wed May 25 06:43:55 CST 2022, time=2022-05-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1068156, encodeId=b97910681564d, content=很有用，所以怎样降低gaba呢, beContent=null, objectType=article, channel=null, level=null, likeNumber=47, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=a3595480171, createdName=ms9000001296012691, createdTime=Mon Nov 08 16:33:23 CST 2021, time=2021-11-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1061670, encodeId=7d4710616e0ff, content=很有用, beContent=null, objectType=article, channel=null, level=null, likeNumber=45, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=925a5640091, createdName=ms6000000105809645, createdTime=Tue Oct 19 05:41:11 CST 2021, time=2021-10-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1872242, encodeId=7d1d18e2242cf, content=<a href='/topic/show?id=fd764459a8' target=_blank style='color:#2F92EE;'>#Cell#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=4459, encryptionId=fd764459a8, topicName=Cell)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=524d95, createdName=zhaozhouchifen, createdTime=Sun Jul 18 13:43:55 CST 2021, time=2021-07-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1005824, encodeId=a138100582478, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=71, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20210804/5785b262ac614e2787c8b09e8d8ae840/5cf1162cd10d42bc817ae4b32662d7f8.jpg, createdBy=c27d4938136, createdName=小小的丁香花, createdTime=Sat Aug 07 15:18:34 CST 2021, time=2021-08-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1004143, encodeId=811c1004143a8, content=ASO是个啥, beContent=null, objectType=article, channel=null, level=null, likeNumber=59, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=bf435331051, createdName=148ccaa6m02暂无昵称, createdTime=Sat Jul 31 05:10:48 CST 2021, time=2021-07-31, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=996264, encodeId=762b99626435, content=如何能看到全文, beContent=null, objectType=article, channel=null, level=null, likeNumber=62, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=4cdb2944259, createdName=63766754, createdTime=Sun Jul 04 23:33:37 CST 2021, time=2021-07-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=978860, encodeId=40499e8860e5, content=学习了！减肥！控制体重！控制血脂胆固醇！有利于血糖控制, beContent=null, objectType=article, channel=null, level=null, likeNumber=39, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=73835475130, createdName=我是谁是我, createdTime=Fri Jul 02 05:58:39 CST 2021, time=2021-07-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=978822, encodeId=77c79e8822d9, content=建议指导性文章不扣或少扣积分, beContent=null, objectType=article, channel=null, level=null, likeNumber=51, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=555f5538552, createdName=微探, createdTime=Thu Jul 01 23:26:01 CST 2021, time=2021-07-01, status=1, ipAttribution=)]
    2021-11-08 ms9000001296012691

    很有用，所以怎样降低gaba呢

    0

  4. [GetPortalCommentsPageByObjectIdResponse(id=1953402, encodeId=6caa1953402e2, content=<a href='/topic/show?id=edbb58e115a' target=_blank style='color:#2F92EE;'>#新途径#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=58711, encryptionId=edbb58e115a, topicName=新途径)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=5e30378, createdName=caobinglei8079, createdTime=Sat Jan 29 17:43:55 CST 2022, time=2022-01-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1962554, encodeId=5b0e196255433, content=<a href='/topic/show?id=dbe6445416' target=_blank style='color:#2F92EE;'>#CEL#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=4454, encryptionId=dbe6445416, topicName=CEL)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c3ff68, createdName=维他命, createdTime=Wed May 25 06:43:55 CST 2022, time=2022-05-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1068156, encodeId=b97910681564d, content=很有用，所以怎样降低gaba呢, beContent=null, objectType=article, channel=null, level=null, likeNumber=47, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=a3595480171, createdName=ms9000001296012691, createdTime=Mon Nov 08 16:33:23 CST 2021, time=2021-11-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1061670, encodeId=7d4710616e0ff, content=很有用, beContent=null, objectType=article, channel=null, level=null, likeNumber=45, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=925a5640091, createdName=ms6000000105809645, createdTime=Tue Oct 19 05:41:11 CST 2021, time=2021-10-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1872242, encodeId=7d1d18e2242cf, content=<a href='/topic/show?id=fd764459a8' target=_blank style='color:#2F92EE;'>#Cell#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=4459, encryptionId=fd764459a8, topicName=Cell)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=524d95, createdName=zhaozhouchifen, createdTime=Sun Jul 18 13:43:55 CST 2021, time=2021-07-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1005824, encodeId=a138100582478, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=71, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20210804/5785b262ac614e2787c8b09e8d8ae840/5cf1162cd10d42bc817ae4b32662d7f8.jpg, createdBy=c27d4938136, createdName=小小的丁香花, createdTime=Sat Aug 07 15:18:34 CST 2021, time=2021-08-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1004143, encodeId=811c1004143a8, content=ASO是个啥, beContent=null, objectType=article, channel=null, level=null, likeNumber=59, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=bf435331051, createdName=148ccaa6m02暂无昵称, createdTime=Sat Jul 31 05:10:48 CST 2021, time=2021-07-31, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=996264, encodeId=762b99626435, content=如何能看到全文, beContent=null, objectType=article, channel=null, level=null, likeNumber=62, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=4cdb2944259, createdName=63766754, createdTime=Sun Jul 04 23:33:37 CST 2021, time=2021-07-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=978860, encodeId=40499e8860e5, content=学习了！减肥！控制体重！控制血脂胆固醇！有利于血糖控制, beContent=null, objectType=article, channel=null, level=null, likeNumber=39, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=73835475130, createdName=我是谁是我, createdTime=Fri Jul 02 05:58:39 CST 2021, time=2021-07-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=978822, encodeId=77c79e8822d9, content=建议指导性文章不扣或少扣积分, beContent=null, objectType=article, channel=null, level=null, likeNumber=51, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=555f5538552, createdName=微探, createdTime=Thu Jul 01 23:26:01 CST 2021, time=2021-07-01, status=1, ipAttribution=)]
    2021-10-19 ms6000000105809645

    很有用

    0

  5. [GetPortalCommentsPageByObjectIdResponse(id=1953402, encodeId=6caa1953402e2, content=<a href='/topic/show?id=edbb58e115a' target=_blank style='color:#2F92EE;'>#新途径#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=58711, encryptionId=edbb58e115a, topicName=新途径)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=5e30378, createdName=caobinglei8079, createdTime=Sat Jan 29 17:43:55 CST 2022, time=2022-01-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1962554, encodeId=5b0e196255433, content=<a href='/topic/show?id=dbe6445416' target=_blank style='color:#2F92EE;'>#CEL#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=4454, encryptionId=dbe6445416, topicName=CEL)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c3ff68, createdName=维他命, createdTime=Wed May 25 06:43:55 CST 2022, time=2022-05-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1068156, encodeId=b97910681564d, content=很有用，所以怎样降低gaba呢, beContent=null, objectType=article, channel=null, level=null, likeNumber=47, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=a3595480171, createdName=ms9000001296012691, createdTime=Mon Nov 08 16:33:23 CST 2021, time=2021-11-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1061670, encodeId=7d4710616e0ff, content=很有用, beContent=null, objectType=article, channel=null, level=null, likeNumber=45, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=925a5640091, createdName=ms6000000105809645, createdTime=Tue Oct 19 05:41:11 CST 2021, time=2021-10-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1872242, encodeId=7d1d18e2242cf, content=<a href='/topic/show?id=fd764459a8' target=_blank style='color:#2F92EE;'>#Cell#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=4459, encryptionId=fd764459a8, topicName=Cell)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=524d95, createdName=zhaozhouchifen, createdTime=Sun Jul 18 13:43:55 CST 2021, time=2021-07-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1005824, encodeId=a138100582478, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=71, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20210804/5785b262ac614e2787c8b09e8d8ae840/5cf1162cd10d42bc817ae4b32662d7f8.jpg, createdBy=c27d4938136, createdName=小小的丁香花, createdTime=Sat Aug 07 15:18:34 CST 2021, time=2021-08-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1004143, encodeId=811c1004143a8, content=ASO是个啥, beContent=null, objectType=article, channel=null, level=null, likeNumber=59, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=bf435331051, createdName=148ccaa6m02暂无昵称, createdTime=Sat Jul 31 05:10:48 CST 2021, time=2021-07-31, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=996264, encodeId=762b99626435, content=如何能看到全文, beContent=null, objectType=article, channel=null, level=null, likeNumber=62, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=4cdb2944259, createdName=63766754, createdTime=Sun Jul 04 23:33:37 CST 2021, time=2021-07-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=978860, encodeId=40499e8860e5, content=学习了！减肥！控制体重！控制血脂胆固醇！有利于血糖控制, beContent=null, objectType=article, channel=null, level=null, likeNumber=39, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=73835475130, createdName=我是谁是我, createdTime=Fri Jul 02 05:58:39 CST 2021, time=2021-07-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=978822, encodeId=77c79e8822d9, content=建议指导性文章不扣或少扣积分, beContent=null, objectType=article, channel=null, level=null, likeNumber=51, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=555f5538552, createdName=微探, createdTime=Thu Jul 01 23:26:01 CST 2021, time=2021-07-01, status=1, ipAttribution=)]
    2021-07-18 zhaozhouchifen

    #Cell#

    0

  6. [GetPortalCommentsPageByObjectIdResponse(id=1953402, encodeId=6caa1953402e2, content=<a href='/topic/show?id=edbb58e115a' target=_blank style='color:#2F92EE;'>#新途径#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=58711, encryptionId=edbb58e115a, topicName=新途径)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=5e30378, createdName=caobinglei8079, createdTime=Sat Jan 29 17:43:55 CST 2022, time=2022-01-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1962554, encodeId=5b0e196255433, content=<a href='/topic/show?id=dbe6445416' target=_blank style='color:#2F92EE;'>#CEL#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=4454, encryptionId=dbe6445416, topicName=CEL)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c3ff68, createdName=维他命, createdTime=Wed May 25 06:43:55 CST 2022, time=2022-05-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1068156, encodeId=b97910681564d, content=很有用，所以怎样降低gaba呢, beContent=null, objectType=article, channel=null, level=null, likeNumber=47, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=a3595480171, createdName=ms9000001296012691, createdTime=Mon Nov 08 16:33:23 CST 2021, time=2021-11-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1061670, encodeId=7d4710616e0ff, content=很有用, beContent=null, objectType=article, channel=null, level=null, likeNumber=45, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=925a5640091, createdName=ms6000000105809645, createdTime=Tue Oct 19 05:41:11 CST 2021, time=2021-10-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1872242, encodeId=7d1d18e2242cf, content=<a href='/topic/show?id=fd764459a8' target=_blank style='color:#2F92EE;'>#Cell#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=4459, encryptionId=fd764459a8, topicName=Cell)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=524d95, createdName=zhaozhouchifen, createdTime=Sun Jul 18 13:43:55 CST 2021, time=2021-07-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1005824, encodeId=a138100582478, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=71, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20210804/5785b262ac614e2787c8b09e8d8ae840/5cf1162cd10d42bc817ae4b32662d7f8.jpg, createdBy=c27d4938136, createdName=小小的丁香花, createdTime=Sat Aug 07 15:18:34 CST 2021, time=2021-08-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1004143, encodeId=811c1004143a8, content=ASO是个啥, beContent=null, objectType=article, channel=null, level=null, likeNumber=59, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=bf435331051, createdName=148ccaa6m02暂无昵称, createdTime=Sat Jul 31 05:10:48 CST 2021, time=2021-07-31, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=996264, encodeId=762b99626435, content=如何能看到全文, beContent=null, objectType=article, channel=null, level=null, likeNumber=62, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=4cdb2944259, createdName=63766754, createdTime=Sun Jul 04 23:33:37 CST 2021, time=2021-07-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=978860, encodeId=40499e8860e5, content=学习了！减肥！控制体重！控制血脂胆固醇！有利于血糖控制, beContent=null, objectType=article, channel=null, level=null, likeNumber=39, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=73835475130, createdName=我是谁是我, createdTime=Fri Jul 02 05:58:39 CST 2021, time=2021-07-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=978822, encodeId=77c79e8822d9, content=建议指导性文章不扣或少扣积分, beContent=null, objectType=article, channel=null, level=null, likeNumber=51, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=555f5538552, createdName=微探, createdTime=Thu Jul 01 23:26:01 CST 2021, time=2021-07-01, status=1, ipAttribution=)]
    2021-08-07 小小的丁香花

    学习了

    0

  7. [GetPortalCommentsPageByObjectIdResponse(id=1953402, encodeId=6caa1953402e2, content=<a href='/topic/show?id=edbb58e115a' target=_blank style='color:#2F92EE;'>#新途径#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=58711, encryptionId=edbb58e115a, topicName=新途径)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=5e30378, createdName=caobinglei8079, createdTime=Sat Jan 29 17:43:55 CST 2022, time=2022-01-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1962554, encodeId=5b0e196255433, content=<a href='/topic/show?id=dbe6445416' target=_blank style='color:#2F92EE;'>#CEL#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=4454, encryptionId=dbe6445416, topicName=CEL)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c3ff68, createdName=维他命, createdTime=Wed May 25 06:43:55 CST 2022, time=2022-05-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1068156, encodeId=b97910681564d, content=很有用，所以怎样降低gaba呢, beContent=null, objectType=article, channel=null, level=null, likeNumber=47, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=a3595480171, createdName=ms9000001296012691, createdTime=Mon Nov 08 16:33:23 CST 2021, time=2021-11-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1061670, encodeId=7d4710616e0ff, content=很有用, beContent=null, objectType=article, channel=null, level=null, likeNumber=45, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=925a5640091, createdName=ms6000000105809645, createdTime=Tue Oct 19 05:41:11 CST 2021, time=2021-10-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1872242, encodeId=7d1d18e2242cf, content=<a href='/topic/show?id=fd764459a8' target=_blank style='color:#2F92EE;'>#Cell#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=4459, encryptionId=fd764459a8, topicName=Cell)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=524d95, createdName=zhaozhouchifen, createdTime=Sun Jul 18 13:43:55 CST 2021, time=2021-07-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1005824, encodeId=a138100582478, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=71, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20210804/5785b262ac614e2787c8b09e8d8ae840/5cf1162cd10d42bc817ae4b32662d7f8.jpg, createdBy=c27d4938136, createdName=小小的丁香花, createdTime=Sat Aug 07 15:18:34 CST 2021, time=2021-08-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1004143, encodeId=811c1004143a8, content=ASO是个啥, beContent=null, objectType=article, channel=null, level=null, likeNumber=59, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=bf435331051, createdName=148ccaa6m02暂无昵称, createdTime=Sat Jul 31 05:10:48 CST 2021, time=2021-07-31, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=996264, encodeId=762b99626435, content=如何能看到全文, beContent=null, objectType=article, channel=null, level=null, likeNumber=62, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=4cdb2944259, createdName=63766754, createdTime=Sun Jul 04 23:33:37 CST 2021, time=2021-07-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=978860, encodeId=40499e8860e5, content=学习了！减肥！控制体重！控制血脂胆固醇！有利于血糖控制, beContent=null, objectType=article, channel=null, level=null, likeNumber=39, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=73835475130, createdName=我是谁是我, createdTime=Fri Jul 02 05:58:39 CST 2021, time=2021-07-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=978822, encodeId=77c79e8822d9, content=建议指导性文章不扣或少扣积分, beContent=null, objectType=article, channel=null, level=null, likeNumber=51, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=555f5538552, createdName=微探, createdTime=Thu Jul 01 23:26:01 CST 2021, time=2021-07-01, status=1, ipAttribution=)]
    2021-07-31 148ccaa6m02暂无昵称

    ASO是个啥

    0

  8. [GetPortalCommentsPageByObjectIdResponse(id=1953402, encodeId=6caa1953402e2, content=<a href='/topic/show?id=edbb58e115a' target=_blank style='color:#2F92EE;'>#新途径#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=58711, encryptionId=edbb58e115a, topicName=新途径)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=5e30378, createdName=caobinglei8079, createdTime=Sat Jan 29 17:43:55 CST 2022, time=2022-01-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1962554, encodeId=5b0e196255433, content=<a href='/topic/show?id=dbe6445416' target=_blank style='color:#2F92EE;'>#CEL#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=4454, encryptionId=dbe6445416, topicName=CEL)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c3ff68, createdName=维他命, createdTime=Wed May 25 06:43:55 CST 2022, time=2022-05-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1068156, encodeId=b97910681564d, content=很有用，所以怎样降低gaba呢, beContent=null, objectType=article, channel=null, level=null, likeNumber=47, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=a3595480171, createdName=ms9000001296012691, createdTime=Mon Nov 08 16:33:23 CST 2021, time=2021-11-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1061670, encodeId=7d4710616e0ff, content=很有用, beContent=null, objectType=article, channel=null, level=null, likeNumber=45, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=925a5640091, createdName=ms6000000105809645, createdTime=Tue Oct 19 05:41:11 CST 2021, time=2021-10-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1872242, encodeId=7d1d18e2242cf, content=<a href='/topic/show?id=fd764459a8' target=_blank style='color:#2F92EE;'>#Cell#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=4459, encryptionId=fd764459a8, topicName=Cell)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=524d95, createdName=zhaozhouchifen, createdTime=Sun Jul 18 13:43:55 CST 2021, time=2021-07-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1005824, encodeId=a138100582478, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=71, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20210804/5785b262ac614e2787c8b09e8d8ae840/5cf1162cd10d42bc817ae4b32662d7f8.jpg, createdBy=c27d4938136, createdName=小小的丁香花, createdTime=Sat Aug 07 15:18:34 CST 2021, time=2021-08-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1004143, encodeId=811c1004143a8, content=ASO是个啥, beContent=null, objectType=article, channel=null, level=null, likeNumber=59, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=bf435331051, createdName=148ccaa6m02暂无昵称, createdTime=Sat Jul 31 05:10:48 CST 2021, time=2021-07-31, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=996264, encodeId=762b99626435, content=如何能看到全文, beContent=null, objectType=article, channel=null, level=null, likeNumber=62, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=4cdb2944259, createdName=63766754, createdTime=Sun Jul 04 23:33:37 CST 2021, time=2021-07-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=978860, encodeId=40499e8860e5, content=学习了！减肥！控制体重！控制血脂胆固醇！有利于血糖控制, beContent=null, objectType=article, channel=null, level=null, likeNumber=39, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=73835475130, createdName=我是谁是我, createdTime=Fri Jul 02 05:58:39 CST 2021, time=2021-07-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=978822, encodeId=77c79e8822d9, content=建议指导性文章不扣或少扣积分, beContent=null, objectType=article, channel=null, level=null, likeNumber=51, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=555f5538552, createdName=微探, createdTime=Thu Jul 01 23:26:01 CST 2021, time=2021-07-01, status=1, ipAttribution=)]
    2021-07-04 63766754

    如何能看到全文

    0

  9. [GetPortalCommentsPageByObjectIdResponse(id=1953402, encodeId=6caa1953402e2, content=<a href='/topic/show?id=edbb58e115a' target=_blank style='color:#2F92EE;'>#新途径#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=58711, encryptionId=edbb58e115a, topicName=新途径)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=5e30378, createdName=caobinglei8079, createdTime=Sat Jan 29 17:43:55 CST 2022, time=2022-01-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1962554, encodeId=5b0e196255433, content=<a href='/topic/show?id=dbe6445416' target=_blank style='color:#2F92EE;'>#CEL#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=4454, encryptionId=dbe6445416, topicName=CEL)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c3ff68, createdName=维他命, createdTime=Wed May 25 06:43:55 CST 2022, time=2022-05-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1068156, encodeId=b97910681564d, content=很有用，所以怎样降低gaba呢, beContent=null, objectType=article, channel=null, level=null, likeNumber=47, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=a3595480171, createdName=ms9000001296012691, createdTime=Mon Nov 08 16:33:23 CST 2021, time=2021-11-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1061670, encodeId=7d4710616e0ff, content=很有用, beContent=null, objectType=article, channel=null, level=null, likeNumber=45, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=925a5640091, createdName=ms6000000105809645, createdTime=Tue Oct 19 05:41:11 CST 2021, time=2021-10-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1872242, encodeId=7d1d18e2242cf, content=<a href='/topic/show?id=fd764459a8' target=_blank style='color:#2F92EE;'>#Cell#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=4459, encryptionId=fd764459a8, topicName=Cell)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=524d95, createdName=zhaozhouchifen, createdTime=Sun Jul 18 13:43:55 CST 2021, time=2021-07-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1005824, encodeId=a138100582478, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=71, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20210804/5785b262ac614e2787c8b09e8d8ae840/5cf1162cd10d42bc817ae4b32662d7f8.jpg, createdBy=c27d4938136, createdName=小小的丁香花, createdTime=Sat Aug 07 15:18:34 CST 2021, time=2021-08-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1004143, encodeId=811c1004143a8, content=ASO是个啥, beContent=null, objectType=article, channel=null, level=null, likeNumber=59, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=bf435331051, createdName=148ccaa6m02暂无昵称, createdTime=Sat Jul 31 05:10:48 CST 2021, time=2021-07-31, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=996264, encodeId=762b99626435, content=如何能看到全文, beContent=null, objectType=article, channel=null, level=null, likeNumber=62, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=4cdb2944259, createdName=63766754, createdTime=Sun Jul 04 23:33:37 CST 2021, time=2021-07-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=978860, encodeId=40499e8860e5, content=学习了！减肥！控制体重！控制血脂胆固醇！有利于血糖控制, beContent=null, objectType=article, channel=null, level=null, likeNumber=39, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=73835475130, createdName=我是谁是我, createdTime=Fri Jul 02 05:58:39 CST 2021, time=2021-07-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=978822, encodeId=77c79e8822d9, content=建议指导性文章不扣或少扣积分, beContent=null, objectType=article, channel=null, level=null, likeNumber=51, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=555f5538552, createdName=微探, createdTime=Thu Jul 01 23:26:01 CST 2021, time=2021-07-01, status=1, ipAttribution=)]
    2021-07-02 我是谁是我

    学习了！减肥！控制体重！控制血脂胆固醇！有利于血糖控制

    0

  10. [GetPortalCommentsPageByObjectIdResponse(id=1953402, encodeId=6caa1953402e2, content=<a href='/topic/show?id=edbb58e115a' target=_blank style='color:#2F92EE;'>#新途径#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=58711, encryptionId=edbb58e115a, topicName=新途径)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=5e30378, createdName=caobinglei8079, createdTime=Sat Jan 29 17:43:55 CST 2022, time=2022-01-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1962554, encodeId=5b0e196255433, content=<a href='/topic/show?id=dbe6445416' target=_blank style='color:#2F92EE;'>#CEL#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=4454, encryptionId=dbe6445416, topicName=CEL)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c3ff68, createdName=维他命, createdTime=Wed May 25 06:43:55 CST 2022, time=2022-05-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1068156, encodeId=b97910681564d, content=很有用，所以怎样降低gaba呢, beContent=null, objectType=article, channel=null, level=null, likeNumber=47, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=a3595480171, createdName=ms9000001296012691, createdTime=Mon Nov 08 16:33:23 CST 2021, time=2021-11-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1061670, encodeId=7d4710616e0ff, content=很有用, beContent=null, objectType=article, channel=null, level=null, likeNumber=45, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=925a5640091, createdName=ms6000000105809645, createdTime=Tue Oct 19 05:41:11 CST 2021, time=2021-10-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1872242, encodeId=7d1d18e2242cf, content=<a href='/topic/show?id=fd764459a8' target=_blank style='color:#2F92EE;'>#Cell#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=4459, encryptionId=fd764459a8, topicName=Cell)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=524d95, createdName=zhaozhouchifen, createdTime=Sun Jul 18 13:43:55 CST 2021, time=2021-07-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1005824, encodeId=a138100582478, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=71, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20210804/5785b262ac614e2787c8b09e8d8ae840/5cf1162cd10d42bc817ae4b32662d7f8.jpg, createdBy=c27d4938136, createdName=小小的丁香花, createdTime=Sat Aug 07 15:18:34 CST 2021, time=2021-08-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1004143, encodeId=811c1004143a8, content=ASO是个啥, beContent=null, objectType=article, channel=null, level=null, likeNumber=59, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=bf435331051, createdName=148ccaa6m02暂无昵称, createdTime=Sat Jul 31 05:10:48 CST 2021, time=2021-07-31, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=996264, encodeId=762b99626435, content=如何能看到全文, beContent=null, objectType=article, channel=null, level=null, likeNumber=62, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=4cdb2944259, createdName=63766754, createdTime=Sun Jul 04 23:33:37 CST 2021, time=2021-07-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=978860, encodeId=40499e8860e5, content=学习了！减肥！控制体重！控制血脂胆固醇！有利于血糖控制, beContent=null, objectType=article, channel=null, level=null, likeNumber=39, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=73835475130, createdName=我是谁是我, createdTime=Fri Jul 02 05:58:39 CST 2021, time=2021-07-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=978822, encodeId=77c79e8822d9, content=建议指导性文章不扣或少扣积分, beContent=null, objectType=article, channel=null, level=null, likeNumber=51, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=555f5538552, createdName=微探, createdTime=Thu Jul 01 23:26:01 CST 2021, time=2021-07-01, status=1, ipAttribution=)]
    2021-07-01 微探

    建议指导性文章不扣或少扣积分

    0

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