Am J Obstet Gynecol:青少年和年轻妇女HPV、沙眼衣原体共同感染的流行病学调查

2016-07-18 Mechront 译 MedSci原创

背景:人乳头瘤病毒(HPV)、沙眼衣原体(CT)共享相同的性传输路线,并具有相同的危险因素,提示合并感染可能对上皮细胞异常的诱导起协同作用。目的:本研究的目的是确定在青少年和年轻女性中的HPV和CT的患病率,并确定与共同感染的因素。方法:本研究包括276名性活跃参与者,年龄在15-24岁。进行了采访、宫颈标本收集行宫颈涂片和分子试验。对所有宫颈标本测试27个HPV基因型,当然通过PCR也对CT进行

背景:人乳头瘤病毒(HPV)、沙眼衣原体(CT)共享相同的性传输路线,并具有相同的危险因素,提示合并感染可能对上皮细胞异常的诱导起协同作用。

目的:本研究的目的是确定在青少年和年轻女性中的HPV和CT的患病率,并确定与共同感染的因素。

方法:本研究包括276名性活跃参与者,年龄在15-24岁。进行了采访、宫颈标本收集行宫颈涂片和分子试验。对所有宫颈标本测试27个HPV基因型,当然通过PCR也对CT进行了检测。

结果:CT和HPV感染率分别为9.1%(95% CI: 5.61-12.4)和47.1%(95% CI:41.0-53.2)。HPV、CT共同感染率为5.8%(95% CI:3.3-9.2);和一种类型HPV的共同感染率为3.3% (95% CI: 1.5-6.1);和多种类型HPV的共同感染率为2.5% (95% CI: 1.0-5.2)。

细胞学异常的患病率为12.3%(95% CI:8.6-16.79)。高风险HPV感染更为普遍(85.4%)。

多元分析后与HPV、CT共同感染相关的独立因素有:开始性活动的年龄在16岁以下(OR=4.9 (95% CI: 1.0-23.63; p = 0.05))、细胞学异常(OR=10.7 (95% CI: 1.9-59.5; p = 0.01))。

结论:人群中共同感染的患病率是一个巨大的,值得关注的公共卫生服务。应对青少年和年轻女性进行CT和HPV感染的检测,以及相应疫苗的接种。细胞学异常和HPV、CT共同感染之间的联系暗示感染在宫颈癌发生中的潜在的协同作用。

原始出处:

Nonato DR, Alves RR,et al.Prevalence and factors associated with co-infection of human papillomavirus and Chlamydia trachomatis in adolescents and young women.Am J Obstet Gynecol. 2016 Jul 8. pii: S0002-9378(16)30436-7. doi: 10.1016/j.ajog.2016.07.003. [Epub ahead of print]

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status=1, ipAttribution=)]
    2017-06-06 yhy100200
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    2016-10-08 1e10c84am36(暂无匿称)

    文章很棒,继续学习

    0

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href='/topic/show?id=a472644828c' target=_blank style='color:#2F92EE;'>#沙眼#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=38, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=64482, encryptionId=a472644828c, topicName=沙眼)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=2c5615156509, createdName=chenshujs, createdTime=Wed Jul 20 06:29:00 CST 2016, time=2016-07-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1566481, encodeId=4d0315664819a, content=<a href='/topic/show?id=a472644828c' target=_blank style='color:#2F92EE;'>#沙眼#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=39, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=64482, encryptionId=a472644828c, topicName=沙眼)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=2c5615156509, createdName=chenshujs, createdTime=Wed Jul 20 06:29:00 CST 2016, time=2016-07-20, status=1, ipAttribution=)]
    2016-07-20 xugumin
  5. 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status=1, ipAttribution=)]
  6. 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status=1, ipAttribution=)]
  7. 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status=1, ipAttribution=)]
  8. 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