Am J Obstet Gynecol:脑-胎盘比是胎儿生长速度受损和不良妊娠结局的判断指标吗?

2017-06-30 Emma MedSci原创

近来很多研究人员认为脑-胎盘比(CPR)是胎儿短期内能否达到生长潜力的一个指标。发表于Am J Obstet Gynecol的一篇文章报道,研究人员对三级转诊中心的单胎妊娠进行回顾群组调查研究,评估低CPR能否作为胎儿生长速度降低的一个指标,并且探究足月时低CPR和胎儿生长速度降低以及不良妊娠结局之间的关系。

近来很多研究人员认为脑-胎盘比(CPR)是胎儿短期内能否达到生长潜力的一个指标。发表于Am J Obstet Gynecol的一篇文章报道,研究人员对三级转诊中心的单胎妊娠产妇进行回顾群组调查研究,评估低CPR能否作为胎儿生长速度降低的一个指标,并且探究低CPR和胎儿生长速度降低以及不良妊娠结局之间的关系。

共有7944个病例,妊娠20-24周时测量腹围,35周和分娩两周记录腹围和胎儿多普勒参数,并分别转换为Z分数和百分位数。运用单变量和多变量Logistic回归分析对数据进行分析比较,分析低CPR和低腹围增长速度之间的关系,识别并调整潜在的混杂因素。作为一个敏感性分析,研究人员还排除小于胎龄儿(SGA)的数据,对模型进行修正。

结果显示,低CPR与低腹围生长速度以及SGA显著相关(P <0.001;P <0.001)。排除SGA后,低CPR与低腹围生长速度以及出生体重百分位数仍然显著相关(P <0.001; P <0.001)。即使在调整脐动脉搏动指数中位值倍数和中脑动脉搏动指数中位值倍数后,手术分娩的必要性和低CPR仍显著相关,排除SGA后得到相似结果。在调整已知的产前产后风险因素后,低CPR仍然与手术分娩的必要性显著相关(P <0.001),同样,在排除SGA后,相关性仍然存在。除此之外,低CPR的适于胎龄儿(AGA),腹围生长速度显著低于具有正常CPR的AGA(P <0.001)。

该研究结果说明,CPR是胎儿生长速度受损和不良妊娠结局的标志物,甚至在使用常规生物测定法认为大小适合的胎儿中。

原始出处:
Khalil, A, et al. Is cerebroplacental ratio a marker of impaired fetal growth velocity and adverse pregnancy outcome? Am J Obstet Gynecol. 2017 Jun;216(6):606.e1-606.e10. doi: 10.1016/j.ajog.2017.02.005.

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    2017-11-16 yahu
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    2018-06-11 yhy100200
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